scholarly journals Inhibition of Proliferation of LNCaP Prostate Cells by Corni Fructus Extract Is Associated with a Decrease in the Expression of Benign Prostatic Hyperplasia-Causing Factors

2021 ◽  
Vol 21 (1) ◽  
pp. 10-21
Author(s):  
Min Yeong Kim ◽  
Seon Yeong Ji ◽  
Hyun Hwangbo ◽  
Hyesook Lee ◽  
Su Hyun Hong ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Inhibition Of Proliferation ◽  
Prostate Cells ◽  
Corni Fructus

Hydrodynamic cavitation kills prostate cells and ablates benign prostatic hyperplasia tissue

2013 ◽  
Vol 238 (11) ◽  
pp. 1242-1250 ◽  
Author(s):  
Zeynep Itah ◽  
Ozlem Oral ◽  
Osman Yavuz Perk ◽  
Muhsincan Sesen ◽  
Ebru Demir ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Hydrodynamic Cavitation ◽  
Prostate Cells ◽  
Benign Prostatic Hyperplasia Tissue

Tamsulosin induces negative signalling for growth and survival in epithelial prostate cells in vivo in benign prostatic hyperplasia (BPH)

2003 ◽  
Vol 2 (1) ◽  
pp. 158
Author(s):  
J. Carballido ◽  
A. Prieto ◽  
M. Sanz ◽  
R. Vela-Navarrete ◽  
C. Korstanje ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Growth And Survival ◽  
Prostate Cells

scholarly journals Oestrogen and benign prostatic hyperplasia: effects on stromal cell proliferation and local formation from androgen

2008 ◽  
Vol 197 (3) ◽  
pp. 483-491 ◽  
Author(s):  
Clement K M Ho ◽  
Jyoti Nanda ◽  
Karen E Chapman ◽  
Fouad K Habib
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Epithelial Cells ◽  
Stromal Cells ◽  
Animal Studies ◽  
Prostatic Hyperplasia ◽  
Aromatase Activity ◽  
Local Formation ◽  
Cells In Culture ◽  
Prostate Cells ◽  
Prostate Growth

Oestrogens have been implicated as a cause of benign prostatic hyperplasia (BPH). Previous animal studies led to the hypothesis that oestrogens can stimulate prostate growth, resulting in hyperplasia of the gland. In humans, the precise role of oestrogens in BPH pathogenesis is currently unclear. We investigated the direct effects of oestradiol on the proliferation of BPH-derived prostate cells in culture. Oestradiol (10−7 and 10−6 M) moderately increased the proliferation of stromal cells in culture; this stimulation was antagonised by anti-oestrogen ICI 182 780, indicating an oestrogen receptor (ER)-mediated mechanism. By contrast, oestradiol had no effects on the proliferation of epithelial cells in culture. Parameters that can determine the response of stromal cells to oestrogens, including expression of the two ER subtypes and aromatase activity, were investigated. ERβ expression in stromal cells in culture was demonstrated by immunohistochemistry and western blot analysis, and was confirmed by semi-quantitative RT-PCR showing higher expression of ERβ than ERα mRNA in stromal cells. Aromatase, the enzyme that converts androgen precursors to oestrogens, was also examined. Aromatase mRNA and activity were detected in stromal, but not epithelial cells in culture, suggesting a mechanism whereby oestrogen concentrations can be regulated in the BPH stroma. Taken together, these findings support the hypothesis that oestrogens play a role in the pathogenesis of BPH, a disease characterised predominantly by stromal overgrowth.

scholarly journals The precursor form of the human kallikrein 2, a kallikrein homologous to prostate-specific antigen, is present in human sera and is increased in prostate cancer and benign prostatic hyperplasia

1998 ◽  
Vol 44 (10) ◽  
pp. 2115-2119 ◽  
Author(s):  
Mohammad S Saedi ◽  
Timothy M Hill ◽  
Kristine Kuus-Reichel ◽  
Abhay Kumar ◽  
Janice Payne ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Benign Prostatic Hyperplasia ◽  
Prostate Specific Antigen ◽  
Prostatic Cancer ◽  
Diagnostic Marker ◽  
Specific Antigen ◽  
Prostatic Hyperplasia ◽  
Prostate Cells ◽  
Human Sera ◽  
Kallikrein 2

Abstract Prostate-specific antigen (PSA, hK3) is a diagnostic marker for prostatic cancer but lacks the specificity to sufficiently distinguish between prostatic cancer and benign prostatic hyperplasia (BPH). Human glandular kallikrein 2 (hK2) has been proposed as a potential diagnostic marker for prostate cancer that could complement the current PSA test. Recently we demonstrated that proPSA is present in prostate cancer sera. This study examines the expression of prohK2 in prostate cells and its presence in human sera. Western blot analysis was used to assess prohK2 expression in the human carcinoma cell line, LNCaP. A highly specific and sensitive dual monoclonal immunoassay for prohK2 was developed and used to assess the presence of prohK2 in human sera. prohK2 was detected in the spent media of LNCaP cells. Furthermore, prohK2 was present at immunodetectable concentrations in human sera, and its concentration was increased in prostatic cancer and BPH. These results indicate for the first time that prohK2 is secreted by human prostate cells and is a major component of uncomplexed (free) hK2 in human sera. In addition, prohK2 in human sera is associated with prostate disease and thus may be a useful marker for prostatic cancer and BPH.

1505: Evaluation of Bother Score for Each Symptom is Necessary for Managemnt of QOL in Patients with Lower Urinary TRCT Symptoms (LUTS) Suggestive of Benign Prostatic Hyperplasia (BPH)

2007 ◽  
Vol 177 (4S) ◽  
pp. 496-497
Author(s):  
Masaki Yoshida ◽  
Akita Inadome ◽  
Koichi Masunaga ◽  
Yoshihiro Maeda ◽  
You Satoji ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Lower Urinary

1438: Benign Prostatic Hyperplasia Outcomes 12 Months after Initiating Medical Management: An Analysis of Managed Care Data

2006 ◽  
Vol 175 (4S) ◽  
pp. 464-465
Author(s):  
Michael J. Naslund ◽  
Muta M. Issa ◽  
Libby Black ◽  
Michael Eaddy ◽  
Manan Shah
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Managed Care ◽  
Medical Management ◽  
Prostatic Hyperplasia

1519: Long Term Outcome of Interstitial Laser Coagulation for Benign Prostatic Hyperplasia

2006 ◽  
Vol 175 (4S) ◽  
pp. 490-490
Author(s):  
Stefan Zastrow ◽  
Sven Oehlschläger ◽  
Oliver W. Hakenberg ◽  
Steffen Leike ◽  
Manfred P. Wirth
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Laser Coagulation ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Interstitial Laser
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