local formation
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Processes ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 163
Author(s):  
Vitali Vasil’evich Starkov ◽  
Ekaterina Alexanrovna Gosteva ◽  
Dmitry Dmitry Zherebtsov ◽  
Maxim Vladimirovich Chichkov ◽  
Nikita Valerievich Alexandrov

This review presents the results of the local formation of nanostructured porous silicon (NPSi) on the surface of silicon wafers by anodic etching using a durite intermediate ring. The morphological and crystallographic features of NPSi structures formed on n- and p-type silicon with low and relatively high resistivity have also been investigated. The proposed scheme allows one to experiment with biological objects (for example, stem cells, neurons, and other objects) in a locally formed porous structure located in close proximity to the electronic periphery of sensor devices on a silicon wafer.


Science ◽  
2021 ◽  
Vol 374 (6575) ◽  
pp. 1598-1605
Author(s):  
Tiarnan A. S. Doherty ◽  
Satyawan Nagane ◽  
Dominik J. Kubicki ◽  
Young-Kwang Jung ◽  
Duncan N. Johnstone ◽  
...  

Author(s):  
Oleg Bashkov ◽  
Anton Bryansky ◽  
Timofey Efimov ◽  
Roman Romashko

The work is devoted to the study of the mechanisms of damage accumulation in a polymer composite material (PCM) during fatigue loading. Mechanical testing of a fiberglass sample was carried out by cyclic tension accompanied by registration of acoustic emission (AE). For the recorded AE signals, the Fourier spectra were calculated and used for clustering with Kohonen self-organizing map. Relations between clusters and types of damage in the PCM structure were established. The analysis of the peak frequencies of the Daubechies D14-wavelet components of AE signals was carried out. Obtained results has allows one to describe the processes of destruction in the PCM sample. It has been established that, on the base of local formation of microdamages in the matrix and the fracture of the fibers detected during recording of the AE data, it is possible to predict the destruction of the polymer composite material, while the beginning of a material destruction can be registered if the damage identified as an adhesion failure is observed. Perspectives of application of adaptive fiber-optic AE sensors for structural monitoring of PCMs on the base of preliminary experimental results are considered and discussed.


2021 ◽  
Vol 21 (10) ◽  
pp. 254
Author(s):  
Zhi-Ying Liu ◽  
Fu-Wen Zhang ◽  
Si-Yuan Zhu

Abstract Gamma-ray bursts (GRBs) are brief, intense, gamma-ray flashes in the universe, lasting from a few milliseconds to a few thousand seconds. For short gamma-ray bursts (sGRBs) with duration less than 2 seconds, the isotropic energy (E iso) function may be more scientifically meaningful and accurately measured than the luminosity (L p) function. In this work we construct, for the first time, the isotropic energy function of sGRBs and estimate their formation rate. First, we derive the L p – E p correlation using 22 sGRBs with known redshifts and well-measured spectra and estimate the pseduo redshifts of 334 Fermi sGRBs. Then, we adopt the Lynden-Bell c − method to study isotropic energy functions and formation rate of sGRBs without any assumption. A strong evolution of isotropic energy E iso ∝ (1+z)5.79 is found, which is comparable to that between L p and z. After removing effect of the cosmic evolution, the isotropic energy function can be reasonably fitted by a broken power law, which is ϕ ( E iso , 0 ) ∝ E iso , 0 − 0.45 for dim sGRBs and ϕ ( E iso , 0 ) ∝ E iso , 0 − 1.11 for bright sGRBs, with the break energy 4.92 × 1049 erg. We obtain the local formation rate of sGRBs is about 17.43 events Gpc−3 yr−1. If assuming a beaming angle is 6° to 26°, the local formation rate including off-axis sGRBs is estimated as ρ 0,all = 155.79 – 3202.35 events Gpc−3 yr−1.


2021 ◽  
pp. 155541202110495
Author(s):  
Miikka J. Lehtonen ◽  
Katharina S. Schilli ◽  
J. Tuomas Harviainen

With the proliferation of technologies and digital platforms, contemporary game development firms’ value propositions have become more complex. While on a global scale a considerable share of the game industry’s revenue is captured by a few dozen firms, we are also witnessing the emergence of local and regional hotspots. In this context, legitimacy is of utmost importance if new competitive advantages are to become institutionalized as an industry. This paper extends studies which have offered temporal snapshots to the regional or local formation of game industry by focusing on the Finnish context. The concept of resilient values is introduced as legitimizing how the game industry is shaped and how the values are interpreted to develop the industry further. Our findings suggest legitimacy is intertwined with resilient values, thus resulting in the industry evolving over time through three different stages: (1) incubation period, (2) growth phase, and (3) institutionalized legitimacy.


Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1466
Author(s):  
Malavika Deodhar ◽  
Jacques Turgeon ◽  
Veronique Michaud

Oxycodone is a widely used opioid for the management of chronic pain. Analgesic effects observed following the administration of oxycodone are mediated mostly by agonistic effects on the μ-opioid receptor. Wide inter-subject variability observed in oxycodone efficacy could be explained by polymorphisms in the gene coding for the μ-opioid receptor (OPRM1). In humans, oxycodone is converted into several metabolites, particularly into oxymorphone, an active metabolite with potent μ-opioid receptor agonist activity. The CYP2D6 enzyme is principally responsible for the conversion of oxycodone to oxymorphone. The CYP2D6 gene is highly polymorphic with encoded protein activities, ranging from non-functioning to high-functioning enzymes. Several pharmacogenetic studies have shown the importance of CYP2D6-mediated conversion of oxycodone to oxymorphone for analgesic efficacy. Pharmacogenetic testing could optimize oxycodone therapy and help achieve adequate pain control, avoiding harmful side effects. However, the most recent Clinical Pharmacogenetics Implementation Consortium guidelines fell short of recommending pharmacogenomic testing for oxycodone treatment. In this review, we (1) analyze pharmacogenomic and drug-interaction studies to delineate the association between CYP2D6 activity and oxycodone efficacy, (2) review evidence from CYP3A4 drug-interaction studies to untangle the nature of oxycodone metabolism and its efficacy, (3) report on the current knowledge linking the efficacy of oxycodone to OPRM1 variants, and (4) discuss the potential role of CYP2D6 brain expression on the local formation of oxymorphone. In conclusion, we opine that pharmacogenetic testing, especially for CYP2D6 with considerations of phenoconversion due to concomitant drug administration, should be appraised to improve oxycodone efficacy.


Author(s):  
R. O. Feschenko ◽  
◽  
R. K. Matyashuk ◽  
A. M. Bilous ◽  
◽  
...  

Tree stand mortality in urban ecosystems indicates the influence level of biotic and abiotic factors primarily on their life state. The significance of these processes lies in the knowledge of the forest stands patterns development and their use for forecasting and assessing ecosystem services. The territories of the nature reserve fund have been taken as research sites, as significant indicators of anthropogenically altered territories. The structure of biomass and forest stands species composition was found to be associated with the growth and development of living trees and the formation of dead trees. Biotic and abiotic factors, intraspecific competition and peculiarities of local formation condition and stands growth are determined to affect the life state of the main forest-forming species directly and indirectly. It was revealed that in the medieval oak plantation, the loss of trees during the research period (2016-2020) prevailed over the increase in the stand ground phytomass. It was found that the carbon deposited amount in the forest stands aboveground phytomass reflects the unusual dynamics for the overwhelming number of territory indicators. The litter formation caused the changes in the deposited carbon structure of the research stands phytomass by tree species. It also led to an increase in the deadwood carbon pool and the onset of carbon emissions from the detritus decomposition.


2021 ◽  
pp. 109158182110229
Author(s):  
Katsu Ishida ◽  
Jonathan A. Werner ◽  
Rhian Davies ◽  
Fan Fan ◽  
Barbara Thomas ◽  
...  

Sotorasib is a first-in-class KRASG12C covalent inhibitor in clinical development for the treatment of tumors with the KRAS p.G12C mutation. A comprehensive nonclinical safety assessment package, including secondary/safety pharmacology and toxicology studies, was conducted to support the marketing application for sotorasib. Sotorasib was negative in a battery of genotoxicity assays and negative in an in vitro phototoxicity assay. Based on in vitro assays, sotorasib had no off-target effects against various receptors, enzymes (including numerous kinases), ion channels, or transporters. Consistent with the tumor-specific target distribution (ie, KRASG12C), there were no primary pharmacology-related on-target effects identified. The kidney was identified as a target organ in the rat but not the dog. Renal toxicity in the rat was characterized by tubular degeneration and necrosis restricted to a specific region suggesting that the toxicity was attributed to the local formation of a putative toxic reactive metabolite. In the 3-month dog study, adaptive changes of hepatocellular hypertrophy due to drug metabolizing enzyme induction were observed in the liver that was associated with secondary effects in the pituitary and thyroid gland. Sotorasib was not teratogenic and had no direct effect on embryo-fetal development in the rat or rabbit. Human, dog, and rat circulating metabolites, M24, M10, and M18, raised no clinically relevant safety concerns based on the general toxicology studies, primary/secondary pharmacology screening, an in vitro human ether-à-go-go-related gene assay, or mutagenicity assessment. Overall, the results of the nonclinical safety program support a high benefit/risk ratio of sotorasib for the treatment of patients with KRAS p.G12C-mutated tumors.


2021 ◽  
Vol 118 (23) ◽  
pp. e2101668118
Author(s):  
Cristiane Sécca ◽  
Jennifer K. Bando ◽  
José L. Fachi ◽  
Susan Gilfillan ◽  
Vincent Peng ◽  
...  

Lymphoid tissue inducer (LTi)-like cells are tissue resident innate lymphocytes that rapidly secrete cytokines that promote gut epithelial integrity and protect against extracellular bacterial infections.Here, we report that the retention of LTi-like cells in conventional solitary intestinal lymphoid tissue (SILT) is essential for controlling LTi-like cell function and is maintained by expression of the chemokine receptor CXCR5. Deletion of Cxcr5 functionally unleashed LTi-like cells in a cell intrinsic manner, leading to uncontrolled IL-17 and IL-22 production. The elevated production of IL-22 in Cxcr5-deficient mice improved gut barrier integrity and protected mice during infection with the opportunistic pathogen Clostridium difficile. Interestingly, Cxcr5−/− mice developed LTi-like cell aggregates that were displaced from their typical niche at the intestinal crypt, and LTi-like cell hyperresponsiveness was associated with the local formation of this unconventional SILT. Thus, LTi-like cell positioning within mucosa controls their activity via niche-specific signals that temper cytokine production during homeostasis.


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