scholarly journals Next-generation sequencing of plasmid carrying blaOXA-48 in Klebsiella pneumoniae from Turkey

2019 ◽  
Vol 66 (2) ◽  
pp. 261-272 ◽  
Author(s):  
Azer Özad Düzgün ◽  
Ayşegül Saral
Keyword(s):  
Next Generation Sequencing ◽  
Klebsiella Pneumoniae ◽  
Next Generation ◽  
Generation Sequencing

scholarly journals Use of Next Generation Sequencing and Synergy Susceptibility Testing in Diagnosis and Treatment of Carbapenem-Resistant Klebsiella pneumoniae Blood Stream Infection

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Yuetian Yu ◽  
Fupin Hu ◽  
Cheng Zhu ◽  
Erzhen Chen ◽  
Liangjing Lu ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Klebsiella Pneumoniae ◽  
Lupus Erythematosus ◽  
Susceptibility Testing ◽  
Blood Stream Infection ◽  
Blood Stream ◽  
Next Generation ◽  
Carbapenem Resistant ◽  
Appropriate Treatment ◽  
Generation Sequencing

Early diagnosis and appropriate treatment for carbapenem-resistant Klebsiella pneumoniae (CR-Kp) infection is a big challenge for clinicians due to its high mortality. Every effort has been made to improve its clinical outcomes. However, treatment according to synergy susceptibility testing has never been reported in the literature. We reported a 29-year-old systemic lupus erythematosus female with CR-Kp blood stream infection. We highlighted the identification by next generation sequencing and treatment according to synergy susceptibility testing in the case.

scholarly journals Investigation of next-generation sequencing data of Klebsiella pneumoniae using web-based tools

2017 ◽  
Vol 66 (11) ◽  
pp. 1673-1683
Author(s):  
Eva Brhelova ◽  
Mariya Antonova ◽  
Filip Pardy ◽  
Iva Kocmanova ◽  
Jiri Mayer ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Klebsiella Pneumoniae ◽  
Next Generation Sequencing Data ◽  
Next Generation ◽  
Sequencing Data ◽  
Web Based ◽  
Generation Sequencing

scholarly journals A case report of pyogenic liver abscess caused by hypervirulent Klebsiella pneumoniae diagnosed by metagenomic next-generation sequencing

2021 ◽  
Vol 49 (7) ◽  
pp. 030006052110327
Author(s):  
Jiafeng Xie ◽  
Zhiqiang Zhu
Keyword(s):  
Case Report ◽  
Next Generation Sequencing ◽  
Klebsiella Pneumoniae ◽  
Liver Abscess ◽  
Pyogenic Liver Abscess ◽  
Next Generation ◽  
Drainage Fluid ◽  
String Test ◽  
History Of ◽  
Generation Sequencing

A 56-year-old woman with a history of diabetes mellitus presented with high fever but no abdominal pain. An abdominal computed tomography scan showed a large liver abscess. Hypervirulent, string test-positive, rmpA/ ampA2-, and iutA-positive Klebsiella pneumoniae was rapidly identified from drainage fluid of the liver abscess using metagenomic next-generation sequencing (mNGS). After intravenous antibiotic therapy and drainage of the abscess, the patient’s condition resolved. This case report highlights the value of mNGS in rapidly and accurately identifying a pathogenic microorganism, which helps reduce the incidence of antimicrobial resistance and enables the targeted use of antibiotics.

scholarly journals Fatal sepsis caused by an unusual Klebsiella species that was misidentified by an automated identification system

2013 ◽  
Vol 62 (5) ◽  
pp. 801-803 ◽  
Author(s):  
Masafumi Seki ◽  
Kazuyoshi Gotoh ◽  
Shota Nakamura ◽  
Yukihiro Akeda ◽  
Tadashi Yoshii ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Klebsiella Pneumoniae ◽  
Identification System ◽  
Next Generation ◽  
Automated Identification ◽  
Klebsiella Species ◽  
Fatal Sepsis ◽  
Generation Sequencing

This is a description of fatal sepsis caused by infection with Klebsiella variicola, which is an isolate genetically related to Klebsiella pneumoniae. The patient’s condition was incorrectly diagnosed as common sepsis caused by K. pneumoniae, which was identified using an automated identification system, but next-generation sequencing and the non-fermentation of adonitol finally identified the cause of sepsis as K. variicola.

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