The retention behavior of antihypertensive drugs of the type angiotensin-converting enzyme inhibitors on thin layers of aminoplast

2002 ◽  
Vol 15 (3) ◽  
pp. 210-213 ◽  
Author(s):  
Nada Perišić-Janjić ◽  
Danica Agbaba
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibitors ◽  
Antihypertensive Drugs ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Thin Layers ◽  
Converting Enzyme ◽  
Retention Behavior ◽  
Converting Enzyme Inhibitors

scholarly journals Features of antihypertensive pharmacotherapy in patients with metabolic syndrome and diabetes mellitus

2021 ◽  
Vol 36 (2) ◽  
pp. 36-44
Author(s):  
O. V. Vlyubchak ◽  
S. V. Dutova ◽  
I. P. Romanova
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Elderly Patients ◽  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibitors ◽  
Antihypertensive Drugs ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Converting Enzyme ◽  
First Line ◽  
Converting Enzyme Inhibitors

The article describes the results of analyzing the available literature concerning specifics of pharmacotherapy for hypertension in elderly patients and patients with metabolic syndrome and diabetes mellitus. Authors present statistical data on the prevalence of hypertension among elderly patients and the incidence of obesity and diabetes in the Russian Federation. The paper highlights the characteristics of clinical course of hypertension in the older age group including the predominance of isolated systolic hypertension, vascular stiffness, and increased endothelial dysfunction. The need for administration of antihypertensive drugs to reduce the risk of complications and improve the quality of life even in older patients is confirmed. The analysis of data from numerous large studies allowed the authors to identify the main principles for selecting antihypertensive drugs in elderly patients. Slow calcium channel blockers, angiotensin converting enzyme inhibitors, and low-dose diuretics should be prescribed as first-line drugs. At the next stage of treatment, in case of unsatisfactory results of initial therapy, the addition of mineralocorticoid receptor antagonists, alpha-blockers, and selective imidazoline receptor agonists should be considered. The main approaches to antihypertensive therapy in patients with metabolic syndrome and diabetes mellitus are described. The authors note the fact of unfavorable impact of metabolic syndrome on cardiovascular system, which provides rationale for aggressive treatment of hypertension in such clinical cases where several drugs may be used to achieve a stable antihypertensive effect. Diuretics, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers are recommended as first-line antihypertensive pharmacotherapy in these patients. The authors argue in favour of the use of antihypertensive drug combinations in one dosage form as one of the effective ways to solve the problem of adherence to treatment in elderly patients and patients with concomitant metabolic disorders.

scholarly journals Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors

2001 ◽  
Vol 66 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Mirjana Aleksic ◽  
Danica Agbaba ◽  
Rada Baosic ◽  
Dusanka Milojkovic-Opsenica ◽  
Zivoslav Tesic
Keyword(s):  
Enzyme Inhibitors ◽  
Antihypertensive Drugs ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Thin Layers ◽  
Converting Enzyme ◽  
Active Components ◽  
Converting Enzyme Inhibitors ◽  
Simple Method ◽  
Pharmacologically Active ◽  
Layer Chromatography

Arapid and simple method for the chromatographic separation of pharmacologically active components contained in some antihypertensive drugs has been developed employing thin-layers of silica gel and polyacrylonitrile sorbent (PANS). The active compounds of Captopril - (S)-1-(3-mercapto-2-methyl-1-oxopropyl)-L-proline, Enalapril - (S)-1- N- 1-(ethoxycarbonyl)-3-phenylpropyl -L-alanyl -L-proline, Lisinopril - (S) -1- N2-(carboxy-3-phenylpropyl)-L-lysyl-L-proline, Quinapril - 3S-2R

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