Topical application of a novel, water-soluble γ-tocopherol derivative prevents UV-induced skin damage in mice

2005 ◽  
Author(s):  
Shingo Yasuoka ◽  
Jiro Takata ◽  
Yoshiharu Karube ◽  
Eiko Katoh ◽  
Toshi Tsuzuki ◽  
...  
Keyword(s):  
Topical Application ◽  
Water Soluble ◽  
Skin Damage

Topical Application of a Novel, Water-soluble γ-Tocopherol Derivative Prevents UV-induced Skin Damage in Mice¶

2007 ◽  
Vol 81 (4) ◽  
pp. 908-913
Author(s):  
Shingo Yasuoka ◽  
Jiro Takata ◽  
Yoshiharu Karube ◽  
Eiko Katoh ◽  
Toshi Tsuzuki ◽  
...  
Keyword(s):  
Topical Application ◽  
Water Soluble ◽  
Skin Damage

Topical Application of a Novel, Water-soluble γ-Tocopherol Derivative Prevents UV-induced Skin Damage in Mice¶

2005 ◽  
Vol 81 (4) ◽  
pp. 908 ◽  
Author(s):  
Shingo Yasuoka ◽  
Jiro Takata ◽  
Yoshiharu Karube ◽  
Eiko Katoh ◽  
Toshi Tsuzuki ◽  
...  
Keyword(s):  
Topical Application ◽  
Water Soluble ◽  
Skin Damage

Protective Effects of Topical Application of a Poorly Soluble Antioxidant Astaxanthin Liposomal Formulation on Ultraviolet-Induced Skin Damage

2012 ◽  
Vol 101 (8) ◽  
pp. 2909-2916 ◽  
Author(s):  
Susumu Hama ◽  
Kanako Takahashi ◽  
Yuko Inai ◽  
Kanako Shiota ◽  
Ryota Sakamoto ◽  
...  
Keyword(s):  
Topical Application ◽  
Liposomal Formulation ◽  
Protective Effects ◽  
Skin Damage ◽  
Poorly Soluble

scholarly journals SULFATION PATHWAYS: Potential benefits of a sulfated resveratrol derivative for topical application

2018 ◽  
Vol 61 (2) ◽  
pp. M27-M39 ◽  
Author(s):  
Marta Correia-da-Silva ◽  
Verónica Rocha ◽  
Cláudia Marques ◽  
Cláudia M Deus ◽  
Adriana Marques-Carvalho ◽  
...  
Keyword(s):  
Protein Content ◽  
Topical Application ◽  
In Silico ◽  
Water Solubility ◽  
Hacat Cell ◽  
Binding Free Energy ◽  
Water Soluble ◽  
Sirtuin 1 ◽  
Trypan Blue Exclusion

Resveratrol (RSV) is a polyphenolic compound with antioxidant, anti-inflammatory and anti-aging properties partly associated with sirtuin 1 (SIRT1)-activation in the skin. However, poor water solubility may limit RSV efficacy. This work aimed to clarify the interest of a new synthetic water-soluble RSV derivative (resveratrol glucoside sulfate, RSV-GS) for topical application. Resveratrol glucoside sulfate was synthesized using microwave-assisted sulfation. Cytotoxicity assays were performed with the keratinocyte HaCaT cell line, using MTT reduction, neutral red uptake, Alamar Blue/resazurin reduction, trypan blue exclusion and measurement of ATP concentration. Western blotting was used to evaluate SIRT1 protein content. Regarding SIRT1 binding, an in silico docking study was performed, using AutoDock Vina. Our results showed that the synthetic derivative RSV-GS was 1000 times more soluble in water than RSV and its non-sulfated glucoside. No relevant decrease in HaCaT cell viability was observed for concentrations up to 5 mM for RSV-GS, and up to 500 μM for resveratrol glucoside, while a significant decrease in HaCaT viability occurred from 100 μM for RSV. RSV-GS and RSV showed a similar behavior regarding protective effect against oxidative stress-induced cytotoxicity. SIRT1 protein content increased after treatment with 500 μM of RSV-GS and 100 μM of RSV. Moreover, in silico studies predicted that RSV-GS binds more stably to SIRT1 with a lower binding free energy than RSV. Although these results support the possible use of RSV-GS in topical formulations, in vivo safety and efficacy studies are needed before considering the use of RSV-GS in commercial products.

Topical Application of Liposomal Antioxidant's for Protection Against CEES Induced Skin Damage

2006 ◽  
Author(s):  
William L. Stone ◽  
Victor Paromov ◽  
Hongsong Yang ◽  
Min Qui
Keyword(s):  
Topical Application ◽  
Skin Damage

Daphne gnidium L. bark and leaf extracts: skin damage by topical application

1998 ◽  
Vol 12 (1) ◽  
pp. 49-51 ◽  
Author(s):  
A. Rapisarda ◽  
M. P. Germanó ◽  
L. Iauk ◽  
M. La Rosa ◽  
R. Sanogo ◽  
...  
Keyword(s):  
Topical Application ◽  
Skin Damage ◽  
Leaf Extracts ◽  
Daphne Gnidium

scholarly journals Anti-Inflammatory and Restorative Effects of Olives in Topical Application

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Mahdiyeh Taheri ◽  
Leila Amiri-Farahani
Keyword(s):  
Olive Oil ◽  
Topical Application ◽  
Skin Diseases ◽  
Skin Damage ◽  
Diaper Dermatitis ◽  
Traditional Treatment ◽  
Frequent Use ◽  
Current Article ◽  
Different Populations ◽  
Anti Inflammatory

Background and Objective. Olive oil is used as a traditional treatment for wounds, sores, and infections, and the effectiveness of topical use and absence of side effects have been reported in various clinical trials. The present study is an overview of the anti-inflammatory properties of olive oil in its topical application for various skin diseases and wounds. Methods. A literature search was conducted (1990–2021) in Medline, Embase, CINAHL, Google Scholar, Science Direct, SID, IranDoc, and Magiran databases. From the 102 reviewed articles, 17 articles were selected to be included in the current article. Results. Various forms of olive have long been used to accelerate the healing of various wounds and skin damage such as diabetic foot ulcers, atopic dermatitis, diaper dermatitis, episiotomy wound, and nipple ulcer but there are still no credible documents or articles that provide reliable evidence of topical use. Conclusion. According to the information obtained from the articles reviewed, olive oil appears to be an effective, safe, and available treatment. This study suggests that olive oil is an alternative remedy to minimize the frequent use of chemical-based treatments. More research may be beneficial to reach certainty in terms of curative properties of olive oil in similar or different injuries in different populations.

Topical Application of Liposomal Antioxidants for Protection Against CEES Induced Skin Damage

2007 ◽  
Author(s):  
William L. Stone ◽  
Victor Paromov ◽  
Hongsong Yang
Keyword(s):  
Topical Application ◽  
Skin Damage

scholarly journals Retinol Has a Skin Dehydrating Effect That Can Be Improved by a Mixture of Water-Soluble Polysaccharides

Cosmetics ◽  
2020 ◽  
Vol 7 (4) ◽  
pp. 80
Author(s):  
James V. Gruber ◽  
Venera Stojkoska ◽  
Jed Riemer
Keyword(s):  
Topical Application ◽  
Untreated Control ◽  
Skin Testing ◽  
Water Soluble ◽  
Skin Hydration ◽  
Short Term ◽  
Study Methods ◽  
Barrier Disruption ◽  
Skin Erythema ◽  
Volar Forearm

It is common that retinoids used in skincare can cause skin dryness, irritation and redness which is a complaint for the use of these molecules in skincare formulations. Objective: to investigate the influence of a mixture of polysaccharides to improve retinol-based formulations in a 12-day inner volar forearm study. Methods: in total, 22 inner volar forearms were treated over a 12-day topical application of a Placebo formulation containing 0.5% retinol verses a formulation containing 0.5% retinol and 3.0% of a complex of polysaccharides. Application occurred 2X/day in the morning and evening. Skin testing included barrier disruption, erythema, and skin hydration. After a 3-day regression of treatment, skin hydration was measured again. Results: the 0.5% retinol Placebo formulation showed a significant impact on skin dehydration compared to untreated control or polysaccharide-treated areas. The formulation containing retinol and 3.0% of the polysaccharides, maintained skin hydration levels comparable to the untreated control. Neither formulation had a statistically significant impact on skin erythema or barrier disruption. After the 3-day regression, the polysaccharide mixture continued to demonstrate significant moisturization benefits superior to the untreated and active-treated sites. Conclusions: a mixture of polysaccharides was able to mitigate the short-term skin drying effects of retinol and continued to moisturize the skin after a 3-Day regression.

scholarly journals 580 Topical application of ST266 reduces UV-induced skin damage

2016 ◽  
Vol 136 (5) ◽  
pp. S103
Author(s):  
E. Galan ◽  
L. Guan ◽  
A. Suggs ◽  
M. Lam ◽  
E. Baron
Keyword(s):  
Topical Application ◽  
Skin Damage
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