scholarly journals Positive effects of renal denervation on markers of cardiovascular inflammation and left ventricular mass. 24-months follow-up

2021 ◽  
Vol 20 (2) ◽  
Author(s):  
E. S. Sitkova ◽  
V. F. Mordovin ◽  
S. E. Pekarskiy ◽  
T. M. Ripp ◽  
T. R. Ryabova ◽  
...  

Aim. To study the long-term effect of renal denervation (RDN) on left ventricular mass (LVM) and inflammatory markers in resistant hypertensive patients.Material and methods. Forty-one patients with resistant hypertension and 24-h blood pressure (BP) 158,7±15,8/87,3+14,6 mmHg, aged 56,6+10,2 years, were enrolled in the study and undergone RDN. Mean 24-h BP, left ventricular mass (transthoracic echocardiography), high sensitivity C-reactive protein (hsCRP), interleukin- 1β (IL­1β), IL-6, IL-10) and tumor necrosis factor alpha (TNF- α) were assessed at baseline and 2 years after the RDN.Results. A baseline prevalence of left ventricular hypertrophy (LVH) was 90,2%. Two years after RDN LVM and interventricular septum (IVS) decreased significantly (p<0.05 for both). Decrease in myocardial mass (∆LVM >0 g) was documented in 24 patients. The regression of LVM was accompanied by a significant decrease in levels of inflammatory markers — hsCRP by 38,3% (p=0,031), TNF-α by 60,7% (p=0,009), IL- 1β — by 71,1% (p=0,001), and IL-10 by 58,2% (p=0,001). In patients in the absence of LVM regression only TNF-α decreased significantly (-68,8%, p=0,001). There was no correlation between changes of LVM and the inflammatory markers at 24 months after RDN.Conclusion. The RDN in RH patients may have long-term cardioprotective effect in terms of significant regress of LVH, which may be partly attributed to the regress in systemic or myocardial inflammation.

2019 ◽  
Vol 37 ◽  
pp. e109
Author(s):  
E. Sitkova ◽  
V. Mordovin ◽  
S. Pekarskii ◽  
T. Ripp ◽  
A. Falkovskaya ◽  
...  

2014 ◽  
Vol 148 (6) ◽  
pp. 2845-2853.e1 ◽  
Author(s):  
Victor X. Mosquera ◽  
Alberto Bouzas-Mosquera ◽  
Victor Bautista-Hernandez ◽  
Francisco Estévez-Cid ◽  
José M. Herrera-Noreña ◽  
...  

1988 ◽  
Vol 6 (4) ◽  
pp. S94-96 ◽  
Author(s):  
Enrico Agabiti-Rosei ◽  
Maria Lorenza Muiesan ◽  
Alessandro Geri ◽  
Giuseppe Romanelli ◽  
Marina Beschi ◽  
...  

2009 ◽  
Vol 32 (8) ◽  
pp. 670-674 ◽  
Author(s):  
Takayoshi Tsutamoto ◽  
Toshinari Tanaka ◽  
Keizo Nishiyama ◽  
Masayuki Yamaji ◽  
Chiho Kawahara ◽  
...  

1991 ◽  
Vol 9 ◽  
pp. S441
Author(s):  
Bjorn Fagerberg ◽  
Marianne Hartford ◽  
Susanne Ljungman ◽  
Goran Berglund ◽  
John Wikstrand

2018 ◽  
Vol 72 (13) ◽  
pp. B184
Author(s):  
Mohammad Thawabi ◽  
Amer Hawatmeh ◽  
Nawar Al Obaidi ◽  
Sarah Studyvin ◽  
Alexis Okoh ◽  
...  

Radiology ◽  
2019 ◽  
Vol 293 (1) ◽  
pp. 107-114 ◽  
Author(s):  
Nadine Kawel-Boehm ◽  
Richard Kronmal ◽  
John Eng ◽  
Aaron Folsom ◽  
Gregory Burke ◽  
...  

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