scholarly journals Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment

2021 ◽  
Vol 54 ◽  
Author(s):  
Saulo Gomes de Oliveira ◽  
Ilana Brito Ferraz de Souza ◽  
Taynan da Silva Constantino ◽  
Paula Carolina Valença Silva ◽  
Elker Lene Santos de Lima ◽  
...  
Keyword(s):  
Specific Treatment ◽  
Mannose Binding Lectin ◽  
Lectin Gene ◽  
Periportal Fibrosis ◽  
Mannose Binding ◽  
Exon 1 ◽  
Fibrosis Regression ◽  
Binding Lectin

Structural Polymorphisms in the Mannose-Binding Lectin Gene Are Associated with Juvenile Idiopathic Arthritis

2009 ◽  
Vol 36 (4) ◽  
pp. 843-847 ◽  
Author(s):  
PÉTER GERGELY ◽  
BORBÁLA PAZÁR ◽  
ZSOLT B. NAGY ◽  
TÍMEA GOMBOS ◽  
KATALIN RAJCZY ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Mannose Binding Lectin ◽  
Healthy Controls ◽  
Promoter Polymorphisms ◽  
Allelic Discrimination ◽  
Lectin Gene ◽  
Mannose Binding ◽  
Exon 1 ◽  
Control Association ◽  
Binding Lectin

Objective.To investigate the possible association between polymorphisms of the mannose-binding lectin gene (MBL2) and susceptibility to juvenile idiopathic arthritis (JIA).Methods.We performed a case-control association study including 118 Hungarian patients with JIA and 118 sex-matched healthy controls. MBL genotyping for the 3 mutant structural alleles at codons 54 (B), 57 (C), and 52 (D) in exon 1 and the promoter polymorphisms at position −550 (HL) and −221 (YX) were carried out by real-time PCR allelic discrimination. Serum level of MBL was determined by ELISA.Results.Variant allele frequencies of both codon 52 and 57 polymorphisms in the MBL2 gene were significantly overrepresented in JIA (p = 0.001 and p = 0.004, respectively). The frequency of low MBL genotypes (XA/XA, YA/YO, XA/YO, and YO/YO) in JIA was higher than that in healthy controls (p = 0.001). Serum MBL concentrations were found to be significantly lower in JIA patients versus control subjects (p = 0.001). The 2 promoter polymorphisms and codon 54 SNP of the MBL2 gene were not associated with JIA.Conclusion.Our findings suggest that genetically determined low MBL levels may predispose children to JIA in a Hungarian population. These data warrant further research to investigate the role of the lectin-dependent complement system in the pathogenesis of JIA.

Molecular cloning and characterization of a mannose-binding lectin gene from Crinum asiaticum

2003 ◽  
Vol 160 (8) ◽  
pp. 913-920 ◽  
Author(s):  
Yourong Chai ◽  
Yongzhen Pang ◽  
Zhihua Liao ◽  
L.e.i. Zhang ◽  
Xiaofen Sun ◽  
...  
Keyword(s):  
Molecular Cloning ◽  
Mannose Binding Lectin ◽  
Lectin Gene ◽  
Mannose Binding ◽  
Crinum Asiaticum ◽  
Binding Lectin

scholarly journals Mannose-binding Lectin Gene Variation and Cardiovascular Disease in Canadian Inuit

1999 ◽  
Vol 45 (8) ◽  
pp. 1283-1285 ◽  
Author(s):  
Robert A Hegele ◽  
Christopher P Busch ◽  
T Kue Young ◽  
Philip W Connelly ◽  
Henian Cao
Keyword(s):  
Cardiovascular Disease ◽  
Mannose Binding Lectin ◽  
Gene Variation ◽  
Lectin Gene ◽  
Mannose Binding ◽  
Binding Lectin

Variants of the Mannose-Binding Lectin Gene in the Benin Population: Heterozygosity for the p.G57E Allele May Confer a Selective Advantage

Human Biology ◽  
2009 ◽  
Vol 81 (5-6) ◽  
pp. 899-909 ◽  
Author(s):  
Omer Placide Dossou-Yovo ◽  
Claudine Lapoumeroulie ◽  
Michelle Hauchecorne ◽  
Isabelle Zaccaria ◽  
Rolande Ducrocq ◽  
...  
Keyword(s):  
Selective Advantage ◽  
Mannose Binding Lectin ◽  
Lectin Gene ◽  
Mannose Binding ◽  
Binding Lectin
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