crinum asiaticum
Recently Published Documents


TOTAL DOCUMENTS

75
(FIVE YEARS 29)

H-INDEX

11
(FIVE YEARS 2)

2021 ◽  
Vol 14 (4) ◽  
pp. 1905-1915
Author(s):  
Michael Ofori ◽  
Cynthia Amaning Danquah ◽  
Selase Ativui ◽  
Peace Doe ◽  
Williams Adu Asamoah

Drug resistant tuberculosis remains one of the major challenges associated with treatment and management of tuberculosis (TB) in the public health system and in clinical settings. In 2020, the World Health Organization (WHO) estimated that about 186,772 people died from drug-resistant tuberculosis out of the 500000 reported cases and this is alarming. There is a pressing need from every angle in drug discovery to develop novel compounds that could possess diverse mechanisms of action to tackle drug-resistant tuberculosis. The Crinum asiaticum bulbs extract are used ethno medicinally to treat upper respiratory tract infections and as well as wound healing agent. The aim of this work is to investigate the in-vitro anti-tuberculosis effect of Crinum asiaticum bulbs extracts and to assess the inhibitory properties against bacteria efflux pumps expression and biofilm formation. The results obtained showed that the Crinum asiaticum bulbs extracts (CAE) were effective in inhibiting Mycobacterium smegmatis (NCTC 8159) and Mycobacterium aurum (NCTC 10437) with minimum inhibitory concentration (MIC) of 125 μg/ml and 250 μg/ml against M. smegmatis and M. aurum respectively. The CAE markedly inhibited the efflux pumps of both M. smegmatis and M. aurum from expressing with the chloroform extract producing the greatest inhibition. The CAE (ethanol, methanol, chloroform and hexane) significantly (***ρ˂0.005) inhibited M. smegmatis’ and M. aurum’s biofilm formation in-vitro. Among the various extracts of Crinum asiaticum, the chloroform extract exhibited the greatest inhibition against M. smegmatis and M. aurum biofilm formation with significance levels of ***ρ˂0.005 and ***ρ˂0.005. In conclusion the CAE has anti-tuberculosis effect and could tackle drug resistant TB as exhibited through the anti-efflux and anti-biofilm forming properties of the extract against the selected Mycobacterium species.


Author(s):  
Abhinav Mishra ◽  
Vikram Singh ◽  
Raj K Prasad ◽  
Mohd Habeeb Ahmad

In the present investigation the glucose lowering potential of the leaf extracts of Crinum asiaticum were prepared using cold maceration technique in solvents of varying polarity. The extracts exhibited the presence of flavonoids, alkaloids, phenolics and tannins. The oral toxicity of the aqueous and ethanolic extracts was determined and these two extracts were used of evaluating the antidiabetic activity. Oral glucose tolerance test was performed and diabetes was induced using alloxan (150 mg/kg) in rats. Ethanolic and aqueous extracts at two dose levels (200 mg/kg and 400mg/kg) were used for evaluating glucose lowering capability. Both the aqueous and the ethanolic extracts were found to significantly reduce glucose levels with the aqueous extract at dose level 200 mg/kg being the most effective (50% reduction) whereas the ethanolic extract was able to reduce the blood glucose by around 35% at the same dose level.


2021 ◽  
Vol 143 ◽  
pp. 133-140
Author(s):  
Michael Ofori ◽  
Cynthia Amaning Danquah ◽  
Paul Poku Sampene Ossei ◽  
Gilbrene Rahamani ◽  
Williams Adu Asamoah ◽  
...  

Planta Medica ◽  
2021 ◽  
Author(s):  
Kiep Minh Do ◽  
Min-Kyoung Shin ◽  
Takeshi Kodama ◽  
Nwet Nwet Win ◽  
Prema Prema ◽  
...  

AbstractThree new flavanols, (2R,3S)-7-methoxy-flavan-3-ol (1), (2R,3S)-7-hydroxy-flavan-3-ol (2), and (2R,3S)-2′-hydroxy-7-methoxy-flavan-3-ol (3), together with two known flavans (4 and 5), were isolated from the chloroform extract of Crinum asiaticum. Their structures were elucidated by various spectroscopic methods, including 1D and 2D NMR, HR-ESI-MS, and CD data. The isolated compounds 1 and 3−5 showed inhibitory activity toward LPS-induced nitric oxide (NO) production. Further investigation of the NF-κB pathway mechanisms indicated that 1 and 3−5 inhibited the LPS-induced IL-6 production and p65 subunit phosphorylation of NF-κB in RAW264.7 cells, with an effective dose of 10 µM.


2021 ◽  
Vol 8 (2) ◽  
pp. 23-35
Author(s):  
Essty Damayanti ◽  
Chaidir Chaidir ◽  
Rachmaniar Rachmat

The development of new and effective pain medications that are natural isexpected to have the benefits of treatment. The purpose of this study was todetermine the antinociceptive effectiveness of a combination of 75% ethanolextract from dandang gendis leaves and 96% ethanol fraction of bakungleaf. In this study was used chemical method induction (Sigmund's method)in 25 male mice which were divided into 5 treatment groups, namelytreatment group I as negative control was given CMC 0.5%, treatmentgroup II as positive control was given acetosal 100 mg / kg BW, treatmentgroups III, IV and V were given combinations extract. Each group was giventreatment orally, thirty minutes then induced with 0.6% acetic acidintraperitonially, after which it was observed and counted for the amount ofstretching for sixty minutes. Data were analyzed by one-way ANOVA test.The results of this study showed that all treatment groups had a significantdifference (p <0.05), the combination of 75% ethanol extract dandanggendis leaf and 96% ethanol fraction of bakung leaf with a dose of 100 mg/ kg BW had good effectiveness with a percent effectiveness value of 92.50%.The results of this study indicate that the combination of 75% ethanolextract from dandang gendis leaf (Clinacanthus nutans (Burn F) Lindau)and 96% ethanol fraction from bakung leaf (Crinum asiaticum) with thesame concentration ratio, have relatively higher antinociceptive of theactivity of each extract, in other words both of them work together.


2021 ◽  
Vol 6 (2) ◽  
Author(s):  
Bayu Kusuma Adi ◽  
Elvis Umbu Lolo ◽  
Richardus Indra Gunawan ◽  
Yonathan Suryo Pambudi

RSUD dr. Soehadi Prijonegoro Sragen produces liquid waste containing microorganisms, toxic and radioactive chemicals. The results of the laboratory examination showed that the liquid waste level always exceeded the quality standard, namely the parameter of phosphate. The phosphate level in September 2013 was 4.80 mg / L, while in December 2013 the concentration was 2.60 mg / L, so  additional  treatment is needed, one of which is phytoremediation using white daffodils (Crinum asiaticum Linn.). This research method is an experimental research design with  pre-post Test with Control Group Design where the wastewater will pass through a wet tank   containing white lily plants with a residence time of 24 hours/day and a treatment rate  of 1100 liters/day. Th research aimed to determine the effect of phytoremediation of white daffodils on the reduction of phosphate levels and the average percentage of its reduction. The results of this study in the ninth and tenth sample collection  met the quality standards of  1.99 mg / L and 1.89 mg / L. Phytoremediation of white daffodils (Crinum asiaticum linn.) may reduce phosphate levels by 45.59%.


2021 ◽  
Vol 307 (2) ◽  
Author(s):  
Yang Huang ◽  
Lan-Ying Liu ◽  
Chang-Qiu Liu ◽  
Qing-Biao Lu ◽  
Qiang-Bang Gong ◽  
...  

2021 ◽  
Vol 9 (02) ◽  
pp. 787-792
Author(s):  
Shahla Firdaus ◽  
◽  
Kamini Kumar ◽  

Crinum asiaticum L. and Crinum latifolium L. are members of the family Amaryllidaceae. Karyomorphological studies of these two species had been performed by using different quantitative and qualitative parameters to know the karyotype asymmetry, which defines the advanced and primitive nature of these two species. The study revealed that Crinum asiaticum L. and Crinum latifolium L. are diploid with 2n=22 chromosomes. based on Total Chromatin Length, Arm Ratio, Gradient Index, Form Percentage, Total Form Percentage, Karyotype Asymmetry Index, Symmetry Index, and Stebbins classification, Crinum asiaticum L. is more advanced than Crinum latifolium L.


2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Chonthicha Kongkwamcharoen ◽  
Arunporn Itharat ◽  
Weerachai Pipatrattanaseree ◽  
Buncha Ooraikul

Crinum asiaticum Linn. has been used in Thai traditional medicine to relieve inflammatory symptoms and treat osteoarthritis. There have been reports on its potent anti-inflammatory property but nothing on the effects of different pretreatments on its chemical properties and anti-inflammatory activity. Pretreatment of herbal raw materials is an important step which affects the overall quality of Thai traditional medicine. The objectives of this study were to investigate different treatments of C. asiaticum leaves prior to ethanolic extraction and to compare the extracts for their anti-inflammatory activity and chemical properties. The treatments included hot air drying in an oven, microwave drying, traditional grilling on a charcoal stove before drying in an oven, and temperature shock in hot and cold water before hot air drying. The anti-inflammatory activity and chemical properties of the extracts were analyzed using the established methods. Results showed that 95% ethanolic extract of hot air oven-dried leaves had the highest anti-inflammatory activity and total phenolic and lycorine contents. We recommend hot air drying as a preextraction treatment for C. asiaticum leaves for its simplicity, best retention of the herbal quality, and suitability for scaling up to an industrial process.


Sign in / Sign up

Export Citation Format

Share Document