scholarly journals Study of implementation and direct cost estimates for diagnostic tests for human visceral leishmaniasis in an urban area in Brazil

2015 ◽  
Vol 31 (10) ◽  
pp. 2127-2136 ◽  
Author(s):  
Tália Santana Machado de Assis ◽  
Paloma Nogueira Guimarães ◽  
Edward Oliveira ◽  
Vanessa Peruhype-Magalhães ◽  
Luciana Inácia Gomes ◽  
...  

Abstract This work reports the process and costs of comprehensively implementing two tests to decentralize the diagnosis of visceral leishmaniasis (VL) in an endemic city in Brazil: a rapid test (IT LEISH) and a direct agglutination test (DAT-LPC). The implementation began by training health professionals to perform the tests. Estimation of the training costs considered the proportional remuneration of all professionals involved and the direct costs of the tests used for training. The study was conducted between November 2011 and November 2013. During that time, 17 training sessions were held, and 175 professionals were trained. The training cost for each professional was US$ 7.13 for the IT LEISH and US$ 9.93 for the DAT-LPC. The direct costs of the IT LEISH and DAT-LPC were estimated to be US$ 6.62 and US$ 5.44, respectively. This first evaluation of the implementation of these diagnostic tests indicates the feasibility of decentralizing both methods to extend access to VL diagnosis in Brazil.

2004 ◽  
Vol 70 (1) ◽  
pp. 78-82 ◽  
Author(s):  
MOHAMMAD ZAHIDUL ISLAM ◽  
IFTIKHAR AHMED ◽  
ABDUL HALIM SARDER ◽  
RUSELLA MIRZA ◽  
EISAKU KIMURA ◽  
...  

2015 ◽  
Vol 10 (3) ◽  
pp. 102-110
Author(s):  
H. Nahrevania ◽  
P. Ghaffarine ◽  
M. Farahmand ◽  
M. Mohebali ◽  
F. Zaboli ◽  
...  

2016 ◽  
Vol 221 ◽  
pp. 9-13 ◽  
Author(s):  
Edward Oliveira ◽  
Juliana Wilke Saliba ◽  
Diana Oliveira ◽  
Edelberto Santos Dias ◽  
Gustavo Fontes Paz

2014 ◽  
Vol 63 (1) ◽  
pp. 106-110
Author(s):  
Saul José Semião-Santos ◽  
Laura Barral Veloso ◽  
Paulo Paes de Andrade ◽  
Marcia Almeida de Melo ◽  
Luis Miguel Lourenço Martins ◽  
...  

We compared the performance of a locally produced β-mercaptoethanol-modified promastigote antigen (β-ME-Ag) of an indigenous Leishmania infantum strain against that of a trypsinized Leishmania donovani reference (REF-Ag) in the direct agglutination test (DAT) for detection of canine visceral leishmaniasis (CVL). One hundred and fifty-one serum samples collected from dogs belonging to four groups with different conditions were included. At a DAT titre of 1 : 320, statistically determined as optimal cut-off value for β-ME-Ag, and 1 : 160 for REF-Ag, a sensitivity and a specificity of 100 % were estimated for β-ME-Ag in comparison with 96.6 % and 100 %, respectively, for REF-Ag. Overall, levels of agglutination titres recorded for the two antigens were highly concordant (Cohen’s κ = 0.879) in both the CVL and non-CVL groups. Based on current results, and ease experienced in processing the antigen and reading the test outcome, we recommend incorporation of β-ME-Ag in DAT for confirmation or exclusion of suspected CVL in dogs.


1996 ◽  
Vol 16 (3-4) ◽  
pp. 235-239 ◽  
Author(s):  
Linda Oskam ◽  
Rob J. Slappendel ◽  
Eef G.M. Beijer ◽  
Nel C.M. Kroon ◽  
Cor W. van Ingen ◽  
...  

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