scholarly journals Cutaneous mast cell tumor in a captive Bush dog (Speothos venaticus): pathological and immunophenotypical aspects - case report

2021 ◽  
Vol 73 (5) ◽  
pp. 1099-1104
Author(s):  
D.O. Santos ◽  
A.R. Oliveira ◽  
T.P. Carvalho ◽  
N.F. Paula ◽  
H.P. Tinoco ◽  
...  
Keyword(s):  
Cell Tumor ◽  
Neoplastic Cells ◽  
Primary Tumors ◽  
Mast Cell Tumor ◽  
Cutaneous Nodule ◽  
Bush Dog ◽  
Cutaneous Mast Cell ◽  
Well Differentiated ◽  
Speothos Venaticus ◽  
Intestinal Adenoma

ABSTRACT A senile male captive bush dog (Speothos venaticus) presented a small perianal cutaneous nodule. Histologically, there was an ulcerated round cell tumor composed of well differentiated mast cells with abundant intracytoplasmic purple Giemsa-positive granules, with a diffuse eosinophilic infiltrate. Immunohistochemistry revealed that 30% of the neoplastic cells were positive for Kit in the cytoplasm and cell membrane, and all neoplastic cells were negative for MAC and CD3. Less than 10% of the neoplastic cells were positive for Ki67. At necropsy other primary tumors were identified in this animal, including an intestinal adenoma, an adrenal cortex adenoma and a testicular interstitial cell tumor.

scholarly journals Morphological Features and KIT Receptor Expression in Canine Cutaneous Mast Cell Tumor and Systemic Mastocytosis / Morfološke Karakteristike I Ekspresija KIT Receptora Kod Kutanih Mastocitoma I Sistemske Mastocitoze Pasa

2015 ◽  
Vol 65 (2) ◽  
pp. 226-237
Author(s):  
Darko Marinković ◽  
Natalija Milčić-Matić ◽  
Milan Jovanović ◽  
Ivana Vučićević ◽  
Slađan Nešić ◽  
...  
Keyword(s):  
Mast Cell ◽  
Systemic Mastocytosis ◽  
Cell Tumor ◽  
Receptor Expression ◽  
Microscopical Examination ◽  
High Grade ◽  
Neoplastic Cells ◽  
Mast Cell Tumor ◽  
Kit Receptor ◽  
Cutaneous Mast Cell

Abstract Mast cell neoplasia in dogs can occur in two different forms: common as cutaneous tumor, or less common as a systemic form of neoplastic mast cell proliferation - systemic mastocytosis. The aim of this study was to compare the histological and cytological features, KIT receptor expression and presence of c-KIT proto-oncogene mutations in neoplastic cells of dogs with canine cutaneous mast cell tumor (CMCT) and systemic mastocytosis. Microscopical examination of the cytological smears obtained from all selected dogs revealed that cellular specimens were constituted mostly of round cells with a central nuclei and fine to coarse purple cytoplasmic granules. Histopathological examination of skin samples of dogs with CMCT and a dog with systemic mastocytosis showed proliferation of the neoplastic mast cells in the superficial and/or deep dermis. Similar findings were observed in tissue samples derived from lymph nodes, spleen, liver, myocardium and kidneys of a dog with systemic mastocytosis. Three dogs with high grade CMCT as well as one dog with systemic mastocytosis showed cytoplasmic CD117 expression, while 3 dogs with low grade CMCT, had membranous expression of CD117. Based on our study, histological features and cytoplasmic CD117 expression in neoplastic cells of dogs with systemic mastocytosis are similar to those in dogs with high grade CMCTs. Nevertheless, mutations of c-KIT proto-oncogene were not found in tumor samples either from dogs with CMCT or dog with systemic mastocytosis.

scholarly journals RETRACTED ARTICLE: Cutaneous mast cell tumor (Mastocytoma): Cyto- histopathological and haematological investigations

2014 ◽  
Vol 9 (1) ◽  
Author(s):  
Ehsan Hosseini ◽  
Behnam Pedram ◽  
Ali Mohammad Bahrami ◽  
Mohammad Hossein Jaberi Moghaddam ◽  
Javad Javanbakht ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Tumor ◽  
Mast Cell Tumor ◽  
Retracted Article ◽  
Cutaneous Mast Cell

scholarly journals Retraction note: Cutaneous mast cell tumor (Mastocytoma): cyto-histopathological and haematological investigations

2016 ◽  
Vol 11 (1) ◽  
Author(s):  
Ehsan Hosseini ◽  
Behnam Pedram ◽  
Ali Mohammad Bahrami ◽  
Mohammad Hossein Jaberi Moghaddam ◽  
Javad Javanbakht ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Tumor ◽  
Mast Cell Tumor ◽  
Cutaneous Mast Cell

scholarly journals Malignant Leydig cell tumor in dogs: two cases and a review of the literature

2019 ◽  
Vol 31 (4) ◽  
pp. 557-561 ◽  
Author(s):  
Tomoo Kudo ◽  
Junichi Kamiie ◽  
Naoyuki Aihara ◽  
Masaki Doi ◽  
Ayumi Sumi ◽  
...  
Keyword(s):  
Leydig Cell ◽  
Testicular Tumor ◽  
Cutaneous Metastasis ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Neoplastic Tissue ◽  
Neoplastic Cells ◽  
Ki 67 ◽  
Primary Tumors ◽  
Eosinophilic Cytoplasm

Malignant Leydig cell tumor (MLCT) is a rare testicular tumor in dogs. We report herein 2 dogs with MLCT and cutaneous metastasis. Grossly, marked enlargement and distortion of the involved testes were noted; on cut surface, the parenchyma was completely replaced by neoplastic tissue. In addition, these tumors had extensive necrosis and hemorrhage. Case 1 had a rapidly growing cutaneous mass in the left angle of the mouth; the lesion was well-circumscribed and had an indistinct lobular pattern. Case 2 had multiple cutaneous masses in the dorsal neck region, the thoracic back region, and the right hindlimb. Microscopically, the tumor lobules were composed of oval-to-polyhedral cells with eosinophilic cytoplasm and resembled testicular tumors. By immunohistochemistry, the neoplastic cells in both the testicular and cutaneous tumors were positive for inhibin-alpha and melan A. The mitotic counts of the primary tumors from cases 1 and 2 were 21 and 11 per 10 high-power fields, respectively. Based on these findings, the cases were diagnosed as MLCT with cutaneous metastasis. Ki-67 expression in the neoplastic cells of the 2 cases was higher than in benign Leydig cell tumors. Our findings may be helpful for the diagnosis of canine MLCT.

18FDG-PET IMAGING IN CANINE LYMPHOMA AND CUTANEOUS MAST CELL TUMOR

2009 ◽  
Vol 50 (2) ◽  
pp. 215-223 ◽  
Author(s):  
AMY K. LEBLANC ◽  
BJOERN W. JAKOBY ◽  
DAVID W. TOWNSEND ◽  
GREGORY B. DANIEL
Keyword(s):  
Mast Cell ◽  
Pet Imaging ◽  
Cell Tumor ◽  
Canine Lymphoma ◽  
18Fdg Pet ◽  
Mast Cell Tumor ◽  
Cutaneous Mast Cell

scholarly journals The Viability of Single Cancer Cells after Exposure to Hydrodynamic Shear Stresses in a Spiral Microchannel: A Canine Cutaneous Mast Cell Tumor Model

Micromachines ◽  
2017 ◽  
Vol 9 (1) ◽  
pp. 9 ◽  
Author(s):  
Dettachai Ketpun ◽  
Achariya Sailasuta ◽  
Thammawit Suwannaphan ◽  
Sudchaya Bhanpattanakul ◽  
Alongkorn Pimpin ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cancer Cells ◽  
Tumor Model ◽  
Cell Tumor ◽  
Shear Stresses ◽  
Mast Cell Tumor ◽  
Hydrodynamic Shear ◽  
Single Cancer ◽  
Cutaneous Mast Cell ◽  
Spiral Microchannel
Sign in / Sign up

Export Citation Format

Share Document