scholarly journals Pulse therapy in pemphigus: report of 11 cases

2013 ◽  
Vol 88 (4) ◽  
pp. 672-675 ◽  
Author(s):  
Nurimar Conceicao Fernandes ◽  
Mariana Menezes
Keyword(s):  
Side Effects ◽  
Maintenance Dose ◽  
Pemphigus Vulgaris ◽  
Pulse Therapy ◽  
Stevens Johnson Syndrome ◽  
Pemphigus Foliaceus ◽  
Cyclophosphamide Pulse Therapy ◽  
Johnson Syndrome ◽  
Cyclophosphamide Pulse

In this study, five cases of pemphigus vulgaris and two cases of pemphigus foliaceus were treated with cyclophosphamide pulse therapy associated with prednisone, resulting in the need for a smaller maintenance dose of prednisone. In three cases of pemphigus vulgaris and one case of pemphigus foliaceus, dexamethasone and cyclophosphamide pulse therapy associated with prednisone helped the lesions to heal more rapidly. Neither treatment however prevented the recurrence of the disease. Amenorrhea, myelotoxicity and Stevens-Johnson syndrome were among the cyclophosphamide side effects. All the patients treated with prednisone experienced known side effects.

scholarly journals Management of Pemphigus Vulgaris Using Dexamethasone Cyclophosphamide Pulse Therapy: A Case Report

2021 ◽  
Vol 12 (5) ◽  
pp. 275-277
Author(s):  
Kriti Sareen ◽  
Fozia Sultana ◽  
Zabin Mirza ◽  
Kalpna Thakur ◽  
Ekta Parmar ◽  
...  
Keyword(s):  
Case Report ◽  
Pemphigus Vulgaris ◽  
Pulse Therapy ◽  
Cyclophosphamide Pulse Therapy ◽  
Cyclophosphamide Pulse

scholarly journals Modifications of pulse therapy in pemphigus: a retrospective study of 72 patients

2019 ◽  
Vol 5 (1) ◽  
pp. 150
Author(s):  
Neela V. Bhuptani ◽  
Khushbu P. Chauhan ◽  
Monal M. Jadwani ◽  
Pooja Raja
Keyword(s):  
Retrospective Study ◽  
Side Effects ◽  
Pemphigus Vulgaris ◽  
Pulse Therapy ◽  
Therapeutic Effects ◽  
Female Ratio ◽  
Number Of Patients ◽  
Iga Pemphigus ◽  
Cyclophosphamide Pulse ◽  
Therapy Protocol

<p class="abstract"><strong>Background:</strong> Pulse therapy defines as the administration of supra-pharmacologic doses of drugs in an intermittent manner to enhance the therapeutic effects and reduce the side effects. Dexamethasone-Cyclophosphamide pulse (DCP) therapy is known since 1986 but there are certain limitations due to side effects of cyclophosphamide.</p><p class="abstract"><strong>Methods:</strong> A retrospective study was carried out where 72 patients of pemphigus were treated with modified pulse therapy like DCP, DAP, DMP from 2006-2016. Modifications were made in DCP therapy protocol and substitution of cyclophosphamide with either azathioprine or methotrexate in few patients.<strong></strong></p><p class="abstract"><strong>Results:</strong> Male to female ratio observed was 1:0.7. Majority of them belonged to age group of 31-40 years (41.66%) followed by 41-50 years (33.3%). Maximum number of patients had pemphigus vulgaris (86.1%) followed by pemphigus foliaceous (12.5%) and IgA pemphigus (1.38%). Good response was observed in patients who took pulse therapy regularly.</p><p class="abstract"><strong>Conclusions:</strong> Modifications to the original DCP therapy protocol were found to be very effective, useful and it shortened the duration of phase I. Side effects were minimal and manageable.</p>

scholarly journals Managing the challenging cases of pemphigus vulgaris with modified pulse therapy: case series

2019 ◽  
Vol 5 (2) ◽  
pp. 434
Author(s):  
Saraswathy P. ◽  
Jayanthi N. S. ◽  
Venkatesh Y.
Keyword(s):  
Therapeutic Response ◽  
Case Series ◽  
Pemphigus Vulgaris ◽  
Pulse Therapy ◽  
Patient Needs ◽  
Skin Infections ◽  
The Third ◽  
Cyclophosphamide Pulse Therapy ◽  
First Case ◽  
Cyclophosphamide Pulse

<p class="abstract">In pemphigus vulgaris, pulse therapy is a promising modality to achieve better therapeutic response and to minimize the side effects of daily steroids. Here we report 5 different challenging situations where we successfully managed with modification of pulse therapy. Our first case had multiple comorbidities with persistent skin infections managed with dexamethasone and cyclophosphamide pulse (DCP) and interval pulse. The second case was unmarried hypertensive male with poor DLQI managed with Azathioprine pulse therapy. The third case was uncontrolled diabetic patient with pulmonary tuberculosis managed with rituximab. The fourth case was diabetic and hypertensive was managed with one day dexamethasone cyclophosphamide pulse therapy (DCP). The fifth case was not completed family with cushingoid features managed with dexamethasone azathioprine pulse therapy (DAP). Pulse therapy is effective in controlling disease activity in pemphigus. But it can be modified in some situations according to the patient needs.</p>

Side-effects of intravenous cyclophosphamide pulse therapy

Lupus ◽  
1997 ◽  
Vol 6 (3) ◽  
pp. 254-257 ◽  
Author(s):  
F. Martin ◽  
B. Lauwerys ◽  
C. Lefèbvre ◽  
J.-P. Devogelaer ◽  
F.A. Houssiau
Keyword(s):  
Side Effects ◽  
Pulse Therapy ◽  
Intravenous Cyclophosphamide ◽  
Cyclophosphamide Pulse Therapy ◽  
Cyclophosphamide Pulse

Autoimmune skin disorders

2013 ◽  
pp. 241-250
Author(s):  
Gavin P Spickett
Keyword(s):  
Epidermolysis Bullosa ◽  
Alopecia Areata ◽  
Pemphigus Vulgaris ◽  
Stevens Johnson Syndrome ◽  
Neutrophilic Dermatosis ◽  
Pemphigus Foliaceus ◽  
Cicatricial Pemphigoid ◽  
Johnson Syndrome ◽  
Acute Febrile Neutrophilic Dermatosis ◽  
Herpes Gestationis

Overview Bullous pemphigoid Herpes gestationis and cicatricial pemphigoid Pemphigus vulgaris Pemphigus foliaceus Paraneoplastic pemphigus Epidermolysis bullosa acquisita Dermatitis herpetiformis (DH) and linear IgA disease Erythema multiforme (EM) Stevens–Johnson syndrome (SJS); toxic epidermal necrolysis (TEN) Sweet’s syndrome (acute febrile neutrophilic dermatosis) Lichen planus (LP) Alopecia areata...

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