scholarly journals Histopathology of cutaneous and mucosal lesions in human paracoccidioidomycosis

1987 ◽  
Vol 29 (2) ◽  
pp. 90-96 ◽  
Author(s):  
Fabio Uribe ◽  
Angela I. Zuluaga ◽  
Walter León ◽  
Angela Restrepo
Keyword(s):  
Foreign Body ◽  
Granulomatous Inflammation ◽  
Giant Cells ◽  
Phagocytic Process ◽  
Pseudoepitheliomatous Hyperplasia ◽  
Additional Finding ◽  
Foreign Body Giant Cells ◽  
Mucosal Lesions

Biopsies from cutaneous and mucosal lesions from 40 patients with active paracoccidioidomycosis, were studied histopathologically. All cases exhibited chronic granulomatous inflammation and 38 also presented suppuration; this picture corresponded to the mixed mycotic granuloma (MMG). Pseudoepitheliomatous hyperplasia and the transepidermic (or epithelial) elimination of the parasite, were observed in all cases. In paracoccidioidomycosis elimination takes place through formation of progressive edema, accompained by exocytosis. The edema gives rise to spongiosis, microvesicles and microabscesses which not only contain the fungus but also, various cellular elements. Cells in charge of the phagocytic process were essentialy Langhans giant cells; PMN's, epithelioid and foreign body giant cells were poor phagocytes. An additional finding was the presence of fibrosis in most biopsies.

Pulmonary hair embolism in a rescued free-ranging Eurasian otter Lutra lutra in Kinmen, Taiwan

2020 ◽  
Vol 142 ◽  
pp. 55-61
Author(s):  
WT Li ◽  
YL Chiang ◽  
TY Chen ◽  
CL Lai
Keyword(s):  
Foreign Body ◽  
Traumatic Injury ◽  
Lung Parenchyma ◽  
Giant Cells ◽  
Hair Shaft ◽  
Lutra Lutra ◽  
Lung Lobe ◽  
Eurasian Otter ◽  
Foreign Body Giant Cells ◽  
Free Ranging

Eurasian otters Lutra lutra are listed as Near Threatened on the IUCN Red List and are imperiled by habitat loss, water pollution, and poaching. Harassment and attacks by stray animals are also recognized threats to the health of wild Eurasian otters. Pulmonary hair embolism is a possible complication in animals with deep traumatic injury, but to date no cases have been reported in wildlife. A free-ranging, adult male Eurasian otter was rescued due to severe emaciation and multiple bite wounds. The otter died 3 d after rescue and was necropsied. Grossly, a 1.5 × 1.5 × 1.5 cm firm nodule was observed in the left cranial lung lobe. Histologically, a fragment of hair shaft surrounded by multinucleated foreign body giant cells was observed in a medium-sized vein, and extensive eosinophilic infiltration was noted in the adjacent vascular wall and lung parenchyma. Based on the gross and histological findings, the pulmonary lesion was consistent with eosinophilic pneumonia and vasculitis induced by hair embolism. The presence of well-formed multinucleated foreign body giant cells and eosinophils may imply a late stage of foreign body reaction, and thus the presumptive source of hair embolism is an animal bite. This is the first report of pulmonary hair embolism associated with animal bite in a rescued free-ranging Eurasian otter.

Comparison of bone wax and chitosan usage on post-sternotomy bone healing

2020 ◽  
pp. 021849232098409
Author(s):  
Ihsanul Amal ◽  
Heroe Soebroto ◽  
Puruhito
Keyword(s):  
Foreign Body ◽  
Bone Healing ◽  
Postoperative Bleeding ◽  
Giant Cells ◽  
Operative Field ◽  
Inflammatory Reactions ◽  
Foreign Body Giant Cells ◽  
New Zealand White Rabbits ◽  
Affect Bone Healing ◽  
Chitosan Powder

Background Sternotomy is a standard approach performed in almost every surgical procedure on the heart and mediastinum. Effective hemostasis of the sternum is required to keep the operative field dry, avoid excessive blood transfusions during surgery, and prevent reoperation due to massive postoperative bleeding, which can further increase morbidity and mortality in patients. Bone wax is a mechanical hemostat commonly used after sternotomy and has been known to affect bone healing, trigger chronic inflammatory reactions, and increase the rate of infection. The application of chitosan, which has intrinsic hemostat ability, as hemostatic material is believed to improve bone healing following sternotomy. This study aimed to compare the effectiveness of bone wax and chitosan on bone healing after sternotomy. Methods Median sternotomies were performed on 2 groups of New Zealand White rabbits. Each group of 16 animals received either bone wax or chitosan powder as hemostatic material. The degree of bone healing, the number of foreign-body giant cells, and the number of osteoblasts were evaluated after 6 weeks. Results Radiographs showed that significantly more animals in the chitosan group had total sternal healing ( p = 0.033). Histopathology revealed that the number of foreign-body giant cells was significantly less ( p = 0.036) and the number of osteoblasts was significantly greater ( p < 0.0001) in the group of animals that received chitosan. Conclusion The use of chitosan as hemostatic material can promote better bone healing compared to bone wax.

Are Langhans giant cells precursors of foreign-body giant cells?

1978 ◽  
Vol 263 (1) ◽  
pp. 13-21 ◽  
Author(s):  
H. J. van der Rhee ◽  
W. Hillebrands ◽  
W. Th. Daems
Keyword(s):  
Foreign Body ◽  
Giant Cells ◽  
Foreign Body Giant Cells

The transformation of langhans giant cells into foreign body giant cells

1979 ◽  
Vol 4 (1) ◽  
pp. 147
Author(s):  
H.J. van der Rhee ◽  
C.P.M. van der Burgh-de Winter ◽  
W.Th. Daems
Keyword(s):  
Foreign Body ◽  
Giant Cells ◽  
Foreign Body Giant Cells

Extracellular matrix receptor and platelet antigens on osteoclasts and foreign body giant cells

1991 ◽  
Vol 96 (2) ◽  
pp. 169-176 ◽  
Author(s):  
J. M. W. Quinn ◽  
N. A. Athanasou ◽  
J.O'D McGee
Keyword(s):  
Extracellular Matrix ◽  
Foreign Body ◽  
Giant Cells ◽  
Foreign Body Giant Cells

scholarly journals REACTIONS OF NORMAL AND TUBERCULOUS ANIMALS TO TUBERCULO-PROTEIN AND TUBERCULO-PHOSPHATIDE

1938 ◽  
Vol 68 (5) ◽  
pp. 641-658 ◽  
Author(s):  
Kenneth C. Smithburn ◽  
Florence R. Sabin
Keyword(s):  
Foreign Body ◽  
Skin Test ◽  
Guinea Pigs ◽  
Cellular Response ◽  
Giant Cells ◽  
Epithelioid Cells ◽  
Tissue Degeneration ◽  
Foreign Body Giant Cells ◽  
Microscopic Reaction

Prior observations on the cellular reactions to tuberculo-phosphatide are confirmed and compared with reactions induced by this material in tuberculous animals. In the latter the response is accelerated and augmented and simulates the Koch phenomenon. Tuberculo-protein produces no macroscopic reaction in normal animals. The microscopic reaction of neutrophiles and monocytes regresses in less than a week. The same material in tuberculous animals causes a response characterized by more or less hemorrhage and necrosis, tissue degeneration, and infiltration of neutrophiles and monocytes. Late in the reaction there may be a few epithelioid cells and foreign body giant cells. Preparations of tuberculo-phosphatide which contain no tubercle bacilli, or only a few, induce the typical cellular response but do not induce hypersensitiveness to tuberculin. Repeated intradermal skin-test injections of tuberculo-protein MA-100 in normal guinea pigs may be followed by a mild hypersensitiveness to subsequent injections.

scholarly journals Pathological changes by Hapalotrema postorchis Rao 1976 (Digenea: Spirorchiidae) in a green turtle Chelonia mydas Linnaeus 1758 (Testudines, Cheloniidae) from Brazil

2015 ◽  
Vol 52 (2) ◽  
pp. 148-154 ◽  
Author(s):  
M. R. Werneck ◽  
G. B. Souza ◽  
B. C. Berger ◽  
A. Trazzi ◽  
R. B. Ribeiro ◽  
...  
Keyword(s):  
Foreign Body ◽  
Aortic Aneurysm ◽  
Atlantic Ocean ◽  
Green Turtle ◽  
Chelonia Mydas ◽  
Giant Cells ◽  
Sea Turtle ◽  
Vascular Lesion ◽  
Pathological Changes ◽  
Foreign Body Giant Cells

SummaryThis note reports the occurrence of Hapalotrema postorchis Rao 1976 collected from an aortic aneurysm in a green turtle (Chelonia mydas Linnaeus 1758) found on the coast of Brazil. Besides the vascular lesion, granulomatous reactions with foreign - body giant cells were found surrounding the parasite eggs in the heart, intestines, liver, pancreas, spleen, brain and kidneys. This paper presents the first report of H. postorchis and accompanying lesions in a green sea turtle from the western South Atlantic Ocean.

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