scholarly journals Effects of lethal and non-lethal malaria on the mononuclear phagocyte system

1983 ◽  
Vol 16 (1) ◽  
pp. 58-67 ◽  
Author(s):  
Carlos Eduardo Tosta ◽  
Greta Ruiz ◽  
Nina Wedderburn
Keyword(s):  
Marginal Zone ◽  
Plasmodium Yoelii ◽  
Mononuclear Phagocyte ◽  
Mononuclear Phagocyte System ◽  
Phagocytic Cells ◽  
Terminal Stage ◽  
Haematopoietic Tissue ◽  
Red Pulp ◽  
Marginal Zone Macrophages

The effects ofone non-lethal species ofmalarialparasite, Plasmodium yoelii, and one lethal species, P. berghei, on the mononuclear phagocyte system (MPS) of BALB/c mice were studied. P. yoelii caused a greater and more sustained expansion and activation of the MPS, and the two major populations of spleen phagocytic cells-red pulp and marginal zone macrophages - exhibited a greater increase in numbers in this infection. During the course of P. berghei mataria, the spleen was progressively occupied by haematopoietic tissue and, at the terminal stage of infection, an extensive depletion of lymphocytes and macrophages was apparent. The possibility was suggested that the outcome of mataria may be inftuenced by the particular way the parasite interacts with the MPS.

Intravascular pulmonary macrophages: a novel cell removes particles from blood

1986 ◽  
Vol 250 (4) ◽  
pp. R728-R732 ◽  
Author(s):  
A. E. Warner ◽  
J. D. Brain
Keyword(s):  
Iron Oxide ◽  
Hepatic Uptake ◽  
Particulate Material ◽  
Mononuclear Phagocyte ◽  
Mononuclear Phagocyte System ◽  
Pulmonary Vasculature ◽  
Organ Distribution ◽  
Phagocytic Cells ◽  
Iron Oxide Particles ◽  
Pulmonary Macrophages

Clearance of radiolabeled gold colloid from the blood and relative organ distribution of retained colloid and magnetic iron oxide particles were compared between rats and calves. When unanesthetized calves 1 wk of age were injected intravenously with these two particle types, uptake was predominantly pulmonary. In contrast, in the rat there was overwhelming hepatic uptake. Similar pulmonary localization of injected particulate material was found in adult goats. When lung tissue was examined by electron microscopy, injected iron oxide was found within intravascular pulmonary macrophages. The mononuclear phagocyte system removes particulate material of both exogenous and endogenous origin from the circulation; hepatic and splenic uptake of such material usually predominates. We found that, unlike the species previously studied, ruminants have actively phagocytic cells within the pulmonary vasculature. Thus pulmonary intravascular macrophages constitute an important part of the mononuclear phagocyte system in some species.

scholarly journals Administration of Liposomal Agents and Blood Clearance Capacity of the Mononuclear Phagocyte System

1998 ◽  
Vol 42 (7) ◽  
pp. 1677-1681 ◽  
Author(s):  
Els W. M. van Etten ◽  
Marian T. ten Kate ◽  
Susan V. Snijders ◽  
Irma A. J. M. Bakker-Woudenberg
Keyword(s):  
Mononuclear Phagocyte ◽  
Mononuclear Phagocyte System ◽  
Prolonged Treatment ◽  
Blood Clearance ◽  
Phagocytic Cells ◽  
Dose Administration ◽  
High Lipid ◽  
Carbon Clearance ◽  
Lipid Dose ◽  
Substantial Extent

ABSTRACT As liposomes are cleared from the circulation to a substantial extent by the phagocytic cells of the mononuclear phagocyte system (MPS), there is a question whether administration of liposome-based therapeutic agents interferes with clearance of infectious organisms by the MPS from blood. In the present study, at first the effect of administration of three types of empty liposomes (devoid of drug), differing in blood residence time, on carbon clearance and bacterial clearance from blood was studied with mice. Classical liposomes (LIP A) and placebo liposomes with lipid composition as in AmBisome (LIP B) or as in Doxil (LIP C) were used. Liposomes were administered intravenously as a single dose. Second, the effect of multiple-dose administration of AmBisome on bacterial blood clearance was studied with rats. AmBisome was administered with two different dosage schedules. The blood clearance capacity of the MPS was monitored at different time points after the last liposome injection. It was shown that the carbon blood clearance capacity of the MPS was impaired only at a high lipid dose of empty classical liposomes. The bacterial blood clearance capacity was never impaired, not even after prolonged treatment with AmBisome administered in a clinically relevant regimen.

scholarly journals Spleen deposition ofCryptococcus neoformanscapsular glucuronoxylomannan in rodents occurs in red pulp macrophages and not marginal zone macrophages expressing the C-type lectin SIGN-R1

2008 ◽  
Vol 46 (2) ◽  
pp. 153-162 ◽  
Author(s):  
Magdia De Jesus ◽  
Chae Gyu Park ◽  
Ya Su ◽  
David L. Goldman ◽  
Ralph M. Steinman ◽  
...  
Keyword(s):  
Marginal Zone ◽  
Red Pulp ◽  
Marginal Zone Macrophages

Enhancing subcutaneous injection and target tissue accumulation of nanoparticles via co-administration with macropinocytosis-inhibiting nanoparticles (MiNP)

2021 ◽  
Author(s):  
Trevor Stack ◽  
Yu-Gang Liu ◽  
Molly Frey ◽  
Sharan Bobbala ◽  
Michael Vincent ◽  
...  
Keyword(s):  
Precision Medicine ◽  
Subcutaneous Injection ◽  
Mononuclear Phagocyte ◽  
Mononuclear Phagocyte System ◽  
Target Tissue ◽  
Diverse Population ◽  
Phagocytic Cells ◽  
Tissue Accumulation

A signficant barrier to the application of nanoparticles for precision medicine is the mononuclear phagocyte system (MPS), a diverse population of phagocytic cells primarily located within the liver, spleen and...

scholarly journals The role of spleen macrophages in malaria: an ultrastructural study

1984 ◽  
Vol 17 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Carlos Eduardo Tosta ◽  
Greta Ruiz ◽  
Nina Wedderburn
Keyword(s):  
Ultrastructural Study ◽  
Plasmodium Berghei ◽  
Marginal Zone ◽  
White Pulp ◽  
Limited Extent ◽  
Phagocytic Cells ◽  
Mantle Zone ◽  
Red Pulp

An electronmicroscopy study of the spleen from mice infected with Plasmodium berghei was carried out to investigate the types ofcells in volved in the removal of parasites from the blood, and the mechanisms by which this occurs. Macrophages, particularly from the red pulp and the marginal zone of the spleen, constituted the most important population of phagocytic cells in the spleen. At the height ofparasitaemia, macrophages in the periphery of the white pulp, especially in the mantle zone of secondary follicles, were also found to participate in phagocytosis, although to a limited extent. Our fingings suggest that phagocytosis of free parasites or parasitized erythrocytes in the spleen is an important mechanism of clearance of parasites from the circulation. Parasites removed from the erythrocytes when these cells cross the interendothelial slits are further phagocytosed by neighbouring macrophages. Evidence is presented suggesting that spleen macrophages may act against the parasite through a process of cytotoxicity.

scholarly journals African Trypanosomiasis-Associated Anemia: The Contribution of the Interplay between Parasites and the Mononuclear Phagocyte System

2018 ◽  
Vol 9 ◽  
Author(s):  
Benoit Stijlemans ◽  
Patrick De Baetselier ◽  
Stefan Magez ◽  
Jo A. Van Ginderachter ◽  
Carl De Trez
Keyword(s):  
Mononuclear Phagocyte ◽  
Mononuclear Phagocyte System ◽  
African Trypanosomiasis
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