scholarly journals Helminths of rabbits (Lagomorpha, Leporidae) deposited in the Helminthological Collection of the Oswaldo Cruz Institute

2004 ◽  
Vol 21 (3) ◽  
pp. 599-604 ◽  
Author(s):  
Roberto Magalhães Pinto ◽  
Delir Corrêa Gomes ◽  
Rodrigo Caldas Menezes ◽  
Cláudia Torres Gomes ◽  
Dely Noronha
Keyword(s):  
Animal Models ◽  
Laboratory Animal ◽  
Oryctolagus Cuniculus ◽  
Scientific Research ◽  
Helminthological Collection ◽  
Cross Reactions

Helminth samples (n = 35) recovered from Oryctolagus cuniculus (Linnaeus, 1758) Lilljeborg, 1873 (3) and from another rabbit species, Sylvilagus brasiliensis (Linnaeus, 1758) Thomas, 1901 (32), from August 1909 to February 1948 and that are deposited in the Helminthological Collection of the Oswaldo Cruz Institute were analyzed. The studied samples were represented by the cysticercus of the cestode Taenia pisiformis (Bloch, 1780) and by the nematodes Passalurus ambiguus (Rudolphi, 1819), Vianella fariasi (Travassos, 1915), Longistriata perfida Travassos, 1943, Trichostrongylus retortaeformis (Zeder, 1800). The scope of the present investigation is to survey the parasites infecting these hosts, commonly used as laboratory animal models in scientific research and supply figurative data on the helminths in order to provide their easy identification, since the presence of autochthonous parasite burdens, if undetected or misinterpreted, can alter the final results of experimental assays, mainly those related to immunological approaches, when cross-reactions can occur.

scholarly journals Laboratory Animal Models for Brucellosis Research

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Teane M. A. Silva ◽  
Erica A. Costa ◽  
Tatiane A. Paixão ◽  
Renée M. Tsolis ◽  
Renato L. Santos
Keyword(s):  
Animal Models ◽  
Chronic Infection ◽  
Laboratory Animal ◽  
Animal Species ◽  
Human Brucellosis ◽  
Intracellular Pathogen ◽  
Gram Negative ◽  
Culture Cells ◽  
Pathogenic Factors ◽  
The World

Brucellosis is a chronic infectious disease caused byBrucellaspp., a Gram-negative facultative intracellular pathogen that affects humans and animals, leading to significant impact on public health and animal industry. Human brucellosis is considered the most prevalent bacterial zoonosis in the world and is characterized by fever, weight loss, depression, hepato/splenomegaly, osteoarticular, and genital infections. Relevant aspects ofBrucellapathogenesis have been intensively investigated in culture cells and animal models. The mouse is the animal model more commonly used to study chronic infection caused byBrucella. This model is most frequently used to investigate specific pathogenic factors ofBrucellaspp., to characterize the host immune response, and to evaluate therapeutics and vaccines. Other animal species have been used as models for brucellosis including rats, guinea pigs, and monkeys. This paper discusses the murine and other laboratory animal models for human and animal brucellosis.

scholarly journals Innovative use of animal models to advance scientific research

2020 ◽  
Vol 380 (2) ◽  
pp. 205-206
Author(s):  
D. K. Meyerholz ◽  
A. P. Beck ◽  
B. Singh
Keyword(s):  
Animal Models ◽  
Scientific Research

scholarly journals A controlled study to investigate anti-diarrhoeal effect of the stem-bark fractions of Terminalia avicennioides in laboratory animal models

2017 ◽  
Vol 5 (1) ◽  
pp. 14-22 ◽  
Author(s):  
Mohammed M. Suleiman ◽  
Balkisu B. Oyelowo ◽  
Ahmed Abubakar ◽  
Mohammed Mamman ◽  
Kamar-deen T. Bello
Keyword(s):  
Animal Models ◽  
Laboratory Animal ◽  
Stem Bark ◽  
Controlled Study

Translational animal models using veterinary patients – An example of canine osteoarthritis (OA)

2012 ◽  
Vol 3 (2) ◽  
pp. 84-89 ◽  
Author(s):  
Outi Vainio
Keyword(s):  
Chronic Pain ◽  
Animal Models ◽  
Laboratory Animal ◽  
The United States ◽  
Reference List ◽  
Pain Research ◽  
Drug Molecules ◽  
Animal Pain ◽  
Pain Models ◽  
Privately Owned

AbstractBackground and purposeThe use of laboratory animals in pain research has powerfully contributed to our detailed understanding of the physiological mechanisms of pain. Animal models also represent an essential tool to screen and select novel drug molecules with potentially analgesic properties. Despite of the inevitable input of laboratory animal trials, recent studies have shown that animal pain models have repeatedly failed to predict clinical analgesic efficacy and adverse side effects of potential drug molecules in human pain patients. This paper provides a review of the laboratory animal models of OA, which have been developed to test efficacy of novel analgesics. The paper also presents spontaneous OA in canine veterinary patients, and methods to observe chronic pain in nonverbal dogs.MethodsPubMed data base was searched as a reference list to locate most relevant articles. A number of 118 articles including 4 reviews were located. Web pages of 4 establishments and 2 private organizations were also accessed.ResultsThe clinical expression and pathogenesis of naturally occurring OA in dogs is considered an analogous disease that occurs in humans, including pain and lameness. OA may occur in any joint in dogs as well as in humans. Primary idiopathic OA in dogs is rare, but certain breeds may be predisposed to it. For the most part, canine OA is considered secondary to acquired or congenital musculoskeletal disorders. Concomitant factors, such as aging and obesity, likely accelerate progression. However, mechanical factors appear to predominate in the etiopathogenesis of canine spontaneous OA. Both subjective (validated questionnaire) and objective (gait analysis) tools are available to measure OA related pain in dogs. Information on the prevalence of canine OA is limited, but rough surveys suggest that 11 million dogs in the United States and 5 million in Europe could suffer from OA. Ethical considerations concerning the use of privately owned dogs can be resolved by a careful experimental design.ConclusionCanine spontaneous OA could serve as a translational animal model that would more closely mimick clinical OA related pain conditions in humans. Privately owned dogs would make a solution to fix the gap between animal pain models and clinical trials when testing potential analgesic drug molecules. Close interdisciplinary cooperation would guarantee that both scientific and ethical intentions would be achieved.ImplicationsThe predictability of translational pain research would improve by using privately owned dogs as chronic pain models when testing novel analgesics.

scholarly journals Genome Resource Banking of Laboratory Animal Models

ILAR Journal ◽  
2000 ◽  
Vol 41 (4) ◽  
pp. 183-186 ◽  
Author(s):  
J. K. Critser ◽  
R. J. Russell
Keyword(s):  
Animal Models ◽  
Laboratory Animal
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