scholarly journals Divergent evolution and purifying selection of the H (FUT1) gene in New World monkeys (Primates, Platyrrhini)

2004 ◽  
Vol 27 (3) ◽  
pp. 342-349
Author(s):  
Bárbara do Nascimento Borges ◽  
Maria Lúcia Harada
2012 ◽  
Vol 4 (2) ◽  
pp. 07-12
Author(s):  
Eliane Santos EVANOVICH ◽  
Maria Lúcia HARADA

ABO locus presents three main alleles: A, B and O. A and B encode glycosyltransferases that catalyze the addiction of an N-GalNac and D-galactose to a precursor substance (H substance), producing A and B antigens, while the O allele does not produce a functional protein. The presence of A and B antigens have been associated to resistance against infectious agents which could use them as attachment factors increasing the virulence of some parasitic agents. As these antigens are not restrict to humans, analyses them in others species, for instance non-human primates, may be crucial to understand the relationship between pathogens and ABO phenotypes. Despite of the relevance of this issue, in the last decade few studies have addressed, mainly in New World Monkeys (NWM), natural reservoir of tropical diseases in Amazon Region. In order to understand the evolution of the ABO system in the primates, it has been obtained the partial sequence of the most important exon of ABO gene (exon 7), in platyrrhini families: Atelidae, Pithecidae and Cebidae. Then, it has been compared the sequences obtained those present in the literature, and measured the selective pressure. The present results shown that residues 266 and 268 are also crucial to distinguish A and B phenotypes in the platyrrhines, such as in catarrhines, and the 266 codon is under positive selection, although the most site codons are under action of purifying selection.


2009 ◽  
Vol 4 (1) ◽  
pp. 23 ◽  
Author(s):  
Maribel Farfán ◽  
David Miñana-Galbis ◽  
M Carmen Fusté ◽  
J Gaspar Lorén

1996 ◽  
Vol 271 (47) ◽  
pp. 30298
Author(s):  
Robert M. Johnson ◽  
Steven Buck ◽  
Chi-hua Chiu ◽  
Horacio Schneider ◽  
Iracilda Sampaio ◽  
...  
Keyword(s):  

Author(s):  
Walter Carl Hartwig ◽  
Alfred L Rosenberger
Keyword(s):  

1969 ◽  
Vol 100 (3) ◽  
pp. 364-375 ◽  
Author(s):  
B. Ehinger ◽  
B. Falck

2007 ◽  
Vol 28 (4) ◽  
pp. 729-759 ◽  
Author(s):  
Gerald H. Jacobs
Keyword(s):  

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