Divergent evolution and purifying selection of the Type 2 diabetes gene sequences in Drosophila: a phylogenomic study

Genetica ◽  
2020 ◽  
Vol 148 (5-6) ◽  
pp. 269-282
Author(s):  
Manoj Kumar Gupta ◽  
Ramakrishna Vadde
Keyword(s):  
Type 2 Diabetes ◽  
Purifying Selection ◽  
Divergent Evolution ◽  
Gene Sequences ◽  
Diabetes Gene ◽  
Phylogenomic Study ◽  
Selection Of

scholarly journals Divergent evolution and purifying selection of the flaA gene sequences in Aeromonas

2009 ◽  
Vol 4 (1) ◽  
pp. 23 ◽  
Author(s):  
Maribel Farfán ◽  
David Miñana-Galbis ◽  
M Carmen Fusté ◽  
J Gaspar Lorén
Keyword(s):  
Purifying Selection ◽  
Divergent Evolution ◽  
Gene Sequences ◽  
Selection Of

The Use of SGLT2i and GLP-1 RA in Patients with Type 2 Diabetes in Thailand: Evidence Review and Recommendations

2021 ◽  
Vol 104 (11) ◽  
pp. 1850-1865
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Lowering ◽  
Sodium Glucose Cotransporter ◽  
Evidence Review ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Glucose Lowering Therapy ◽  
The Cost ◽  
Selection Of

Background: Cardiovascular (CV) and renal comorbidities are common among type 2 diabetes (T2D) patients, and significantly increase the cost and burden of care. Both sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RA) improve key outcomes including major CV events, hospitalization for heart failure, and renal outcomes, albeit to varying degrees in different T2D populations. Materials and Methods: The authors reviewed evidence from GLP-1 RA and SGLT2i CV outcomes trials and real-world studies in Thailand and elsewhere. Results: The authors formulated recommendations to guide selection of anti-diabetes medication based on patients’ clinical characteristics and CV or renal risk profile. Conclusion: These recommendations could help guide management of CV/renal comorbidities and risk alongside glucose-lowering therapy for individual patients. Keywords: Type 2 diabetes mellitus; Cardiovascular diseases; Chronic kidney disease; Clinical outcomes; SGLT2i; GLP-1 RA

scholarly journals Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene

Diabetologia ◽  
2009 ◽  
Vol 52 (7) ◽  
pp. 1240-1249 ◽  
Author(s):  
H. Mulder ◽  
C. L. F. Nagorny ◽  
V. Lyssenko ◽  
L. Groop
Keyword(s):  
Type 2 Diabetes ◽  
Pancreatic Islets ◽  
Melatonin Receptors ◽  
Good Morning ◽  
Diabetes Gene

scholarly journals The Carnivore Connection Hypothesis: Revisited

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Jennie C. Brand-Miller ◽  
Hayley J. Griffin ◽  
Stephen Colagiuri
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Selection Pressure ◽  
Glycemic Load ◽  
Dietary Carbohydrate ◽  
Recent Exposure ◽  
Agricultural Revolution ◽  
High Prevalence ◽  
Selection Of

The “Carnivore Connection” hypothesizes that, during human evolution, a scarcity of dietary carbohydrate in diets with low plant : animal subsistence ratios led to insulin resistance providing a survival and reproductive advantage with selection of genes for insulin resistance. The selection pressure was relaxed at the beginning of the Agricultural Revolution when large quantities of cereals first entered human diets. The “Carnivore Connection” explains the high prevalence of intrinsic insulin resistance and type 2 diabetes in populations that transition rapidly from traditional diets with a low-glycemic load, to high-carbohydrate, high-glycemic index diets that characterize modern diets. Selection pressure has been relaxed longest in European populations, explaining a lower prevalence of insulin resistance and type 2 diabetes, despite recent exposure to famine and food scarcity. Increasing obesity and habitual consumption of high-glycemic-load diets worsens insulin resistance and increases the risk of type 2 diabetes in all populations.

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