scholarly journals Ventricular function in Chagas' heart disease

1995 ◽  
Vol 113 (2) ◽  
pp. 814-820 ◽  
Author(s):  
Benedito Carlos Maciel ◽  
Oswaldo César de Almeida Filho ◽  
André Schmidt ◽  
José Antonio Marin-Neto
Keyword(s):  
Heart Rate ◽  
Heart Disease ◽  
Ventricular Function ◽  
Chagas Disease ◽  
Loading Conditions ◽  
Noninvasive Methods ◽  
Ventricular Performance ◽  
Chagas Heart Disease

Invasive and noninvasive methods used to evaluate ventricular function in Chagas's disease are reviewed. The traditional indices of overall ventricular performance reflect interaction of preload, contractility, afterload and heart rate. Therefore, they are unable to distinguish changes in contractility from modifications of loading conditions. The role of ventricular function as a predictor of mortality in chronic Chagas' heart disease is discussed. Ventricular function abnormalities in patients with indeterminate and digestive forms of Chagas' disease are especially emphasized. Finally, the evidence of early impairment of diastolic performance in patients with Chagas' disease is presented.

Response of heart rate to atropine and left ventricular function in Chagas' heart disease

1988 ◽  
Vol 21 (2) ◽  
pp. 143-152 ◽  
Author(s):  
Diego F. Davila ◽  
Jose H. Donis ◽  
Maria Navas ◽  
Abdel J. Fuenmayor ◽  
Argenis Torres ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Disease ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Left Ventricular ◽  
Chagas Heart Disease

scholarly journals Ethiological treatment of acute and chronic Chagas' heart disease

1995 ◽  
Vol 113 (2) ◽  
pp. 867-872 ◽  
Author(s):  
Abílio Augusto Fragata Filho ◽  
Marco Aurélio Dias da Silva ◽  
Elias Boainain
Keyword(s):  
Heart Disease ◽  
Chagas Disease ◽  
Acute Phase ◽  
Randomized Trials ◽  
Research Protocol ◽  
Infection Route ◽  
End Of Treatment ◽  
Toxic Agents ◽  
Chagas Heart Disease

The uncertaintties in the ethiological treatment of Chagas' Disease are consequence of the lack of entire knowledge of its pathogeny and the no existence of a healing criterium. There is a consensus that antiparasite drugs should be used in the acute phase of the infection, regardless of the infection route, in new crisis, in patients under immunossuppression and in organs transplantation. There is still controversy regarding subacute, chronic or indetermined phase or cases with mild cardiac/digestive forms, not included in the situations listed above neither in a research protocol. The treatment includes oral benzonidazol 5 mg/kg/day, bid or tid for 60 days. In 71 patients monitored in this fashion, the authors have found 60% of negative xenodiagnostic at the end of treatment. It is still necessary, however, to continue to investigate and accomplishing more randomized trials to confirm the efficacy of such method, and also to try to obtain effective and less toxic agents. It is also fundamental to standardize a more reliable healing criterium.

Heart rate dynamics before the spontaneous onset of ventricular tachyarrhythmias in chagas’ heart disease

2001 ◽  
Vol 87 (9) ◽  
pp. 1123-1125 ◽  
Author(s):  
Jorge O Dı́az ◽  
Timo H Mäkikallio ◽  
Heikki V Huikuri ◽  
Gustavo Lopera ◽  
Raul D Mitrani ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Disease ◽  
Ventricular Tachyarrhythmias ◽  
Heart Rate Dynamics ◽  
Chagas Heart Disease ◽  
Spontaneous Onset

scholarly journals Ivabradinum supplements the clinical efficacy of percutaneous coronary intervention in patients with coronary heart disease with stable angina

2017 ◽  
Vol 8 (2) ◽  
pp. 35-43
Author(s):  
D. M Aronov ◽  
M. G Bubnova
Keyword(s):  
Heart Rate ◽  
Percutaneous Coronary Intervention ◽  
Heart Disease ◽  
Stable Angina ◽  
Clinical Effect ◽  
Coronary Intervention ◽  
Modern Drug ◽  
Percutaneous Coronary ◽  
Reperfusion Of The Myocardium

The review is devoted to the role of ivabradinum in the procedure of percutaneous coronary intervention (PCI) in patients with ischemic heart disease with stable angina. It is reported that reperfusion of the myocardium with PCI, even in combination with modern drug therapy, does not have a complete clinical effect. The authors substantiate the possibility of completing the clinical effect of PCI in such patients by prescribing ivabradinum. The drug reduces the heart rate more than with medication without it.

scholarly journals A doença de chagas e a cardiopatia chagásica crônica: uma revisão de literatura / Chagas disease and chronic chagas heart disease: literature review

2021 ◽  
Vol 7 (12) ◽  
pp. 112598-112615
Author(s):  
Camila Maria Braga Tameirão ◽  
Luiza Junqueira de Miranda ◽  
Maria Eduarda Ferreira Gomes ◽  
Maria Gabriela Elias D’Assumpção ◽  
Milton Henriques Guimarães Junior
Keyword(s):  
Heart Disease ◽  
Literature Review ◽  
Chagas Disease ◽  
Chagas Heart Disease

scholarly journals Heart transplants for patients with Chagas' heart disease

1995 ◽  
Vol 113 (2) ◽  
pp. 873-879 ◽  
Author(s):  
Edimar Alcides Bocchi
Keyword(s):  
Heart Disease ◽  
Chagas Disease ◽  
Left Ventricular ◽  
Ventricular Ejection ◽  
Left Ventricular Ejection ◽  
Heart Transplants ◽  
Ventricular Ejection Fraction ◽  
Chagas Heart Disease ◽  
The Mean ◽  
Cruzi Infection

The role of heart transplants for treating Chagas' heart disease is not quite clear. Immunosuppression could lead to resurgence of T. cruzi infection with acute or chronic damage to the allograft. There are few publications regarding this issue. Thus we reported the follow-up of 18-patients with Chagas' heart disease submitted to orthotopic heart transplants from 1985 to 1993 at The Heart Institute. The patients were in functional class IV or III, or II, with sustained ventricular tachycardia episodes. The mean left ventricular ejection fraction was 25 ± 9% and the mean right ventricular ejection was 22 ± 6% (MUGA). Immunosuppression was based on cyclosporin, azathioprine and corticosteroids. For specific post-transplant monitoring of T. cruzi infection, blood tests were performed (examination of blood or leukocyte concentrate, Giemsa-stained blood smears, blood culture, xenodiagnosis, mouse inoculation) and tissue biopsy (skin or myocardium). In addition, complement fixation hemagglutination and immunofluorescence assays were performed. T. cruzi parasitemias were detected in 18 circumstances in 13 patients. Resurgence of Chagas' disease was diagnosed in 11 circumstances in 5 patients. Fever, subcutaneous nodules and myocarditis predominated in these episodes. All episodes of parasitemia and Chagas' disease resurgence were successfully treated with benzonidazole. All surviving patients had normal cardiac function despite left ventricular function worsening during some myocarditis episodes. Neoplasias were important findings and 3 patients developed lymphoproliferative disease, 2 developed Karposi's sarcoma and 1 patient developed skin cancer. The survival rates at 4 and 12 months were 83% and 49% respectively. The survival of patients who underwent heart transplants from August 1991 to April 1993 was 100% at 4 months and 75% at 12 months. Heart transplants for Chagas' heart disease may be associated with episodes of parasitemia and a reoccurrence of episodes of Chaga's disease. The survival of heart transplanted patients has improved when associated with lower doses of cyclosporins and thus, fewer resurgences of the disease.

scholarly journals Effects of an exercise program on blood pressure in patients with treated hypertension and chronic Chagas' heart disease

2012 ◽  
Vol 45 (6) ◽  
pp. 727-731 ◽  
Author(s):  
Claudia Rosa de Oliveira ◽  
Andréa Silvestre de Sousa ◽  
Bráulio Santos ◽  
Paloma Hargreaves Fialho ◽  
Carla Cristiane Soares dos Santos ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Disease ◽  
Chagas Disease ◽  
Blood Pressure Monitoring ◽  
Exercise Program ◽  
Study Results ◽  
Before And After ◽  
Chagas Heart Disease ◽  
Blood Pressures ◽  
Chronic Chagas Disease

INTRODUCTION: Previous studies describe an imbalance of the autonomic nervous system in Chagas' disease causing increased sympathetic activity, which could influence the genesis of hypertension. However, patients undergoing regular physical exercise could counteract this condition, considering that exercise causes physiological responses through autonomic and hemodynamic changes that positively affect the cardiovascular system. This study aimed to evaluate the effects of an exercise program on blood pressure in hypertensive patients with chronic Chagas' heart disease. METHODS: We recruited 17 patients to a 24-week regular exercise program and used ambulatory blood pressure monitoring before and after training. We determined the differences in the systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean blood pressure (MBP) from the beginning to the end of the study. RESULTS: The blood pressures were evaluated in general and during periods of wakefulness and sleep, respectively: SBP (p = 0.34; 0.23; 0.85), DBP (p = 0.46; 0.44; 0.94) and MBP (p = 0.41; 0.30; 0.97). CONCLUSIONS: There was no statistically significant change in blood pressure after the 24-week exercise program; however, we concluded that physical training is safe for patients with chronic Chagas' disease, with no incidence of increase in blood pressure.

scholarly journals Effects of an exercise program on the functional capacity of patients with chronic Chagas' heart disease, evaluated by cardiopulmonary testing

2012 ◽  
Vol 45 (2) ◽  
pp. 220-224 ◽  
Author(s):  
Paloma Hargreaves Fialho ◽  
Bernardo Rangel Tura ◽  
Andréa Silvestre de Sousa ◽  
Claudia Rosa de Oliveira ◽  
Carla Cristiane Santos Soares ◽  
...  
Keyword(s):  
Heart Disease ◽  
Chagas Disease ◽  
Functional Capacity ◽  
Severe Heart Failure ◽  
Exercise Program ◽  
Public Health Problem ◽  
Cardiopulmonary Exercise Test ◽  
Regular Exercise ◽  
Aerobic Activity ◽  
Chagas Heart Disease

INTRODUCTION: Despite all efforts to restrict its transmission, Chagas' disease remains a severe public health problem in Latin America, affecting 8-12 million individuals. Chronic Chagas' heart disease, the chief factor in the high mortality rate associated with the illness, affects more than half a million Brazilians. Its evolution may result in severe heart failure associated with loss of functional capacity and quality of life, with important social and medical/labor consequences. Many studies have shown the beneficial effect of regular exercise on cardiac patients, but few of them have focused on chronic Chagas' heart disease. METHODS: This study evaluated the effects of an exercise program on the functional capacity of patients with chronic Chagas' disease who were treated in outpatient clinics at the Evandro Chagas Institute of Clinical Research and the National Institute of Cardiology, Rio de Janeiro, Brazil. The exercises were performed 3 times a week for 1 h (30 min of aerobic activity and 30 min of resistance exercises and extension) over 6 months in 2010. Functional capacity was evaluated by comparing the direct measurement of the O2 uptake volume (VO2) obtained by a cardiopulmonary exercise test before and after the program (p < 0.05). RESULTS: Eighteen patients (13 females) were followed, with minimum and maximum ages of 30 and 72 years, respectively. We observed an average increase of VO2peak > 10% (p = 0.01949). CONCLUSIONS: The results suggest a statistically significant improvement in functional capacity with regular exercise of the right intensity.

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