Embryo development alteration in rats treated with lapachol

Lapachol, a naphthoquinone extracted from plants of the genus Tabebuia (family Bignoneaceae), showed multiple therapeutic activities. Pregnant Wistar rats were treated with Lapachol from the 1st to the 4th (pre-implantation period) and from 5th to 7th (implantation period) post insemination day (PID). Mothers were sacrificed on the 5th or on the15th PID. Number of corpora lutea, preimplantation embryo, blastocysts, live and dead fetuses and resorptions were counted. There were no signs of maternal toxicity. The number and the morphology of embryos, during oviduct development (pre-implantation period), did not seem to be affected by this drug, but during the implantation period, lapachol was toxic causing the death of embryos and intrauterine growth retardation.

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Intrauterine growth retardation and lack of teratogenic effects of prenatal exposure to the combination of paracetamol and caffeine in Wistar rats

Reproductive Toxicology ◽

10.1016/s0890-6238(02)00097-7 ◽

2003 ◽

Vol 17 (1) ◽

pp. 51-58 ◽

Cited By ~ 12

Author(s):

F Burdan

Keyword(s):

Prenatal Exposure ◽

Growth Retardation ◽

Wistar Rats ◽

Intrauterine Growth Retardation ◽

Teratogenic Effects ◽

Intrauterine Growth

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Corrigendum to “Intrauterine growth retardation and lack of teratogenic effects of prenatal exposure to the combination of paracetamol and caffeine in Wistar rats”

Reproductive Toxicology ◽

10.1016/j.reprotox.2004.02.004 ◽

2004 ◽

Vol 18 (3) ◽

pp. 449

Author(s):

Franciszek Burdan

Keyword(s):

Prenatal Exposure ◽

Growth Retardation ◽

Wistar Rats ◽

Intrauterine Growth Retardation ◽

Teratogenic Effects ◽

Intrauterine Growth

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Foetal hepatorenal toxicity and intrauterine growth retardation in pregnant Wistar rats treated with artemether

Anatomy (International Journal of Experimental and Clinical Anatomy) ◽

10.2399/ana.17.012 ◽

2018 ◽

Vol 12 (1) ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Idorenyin Udo Umoh ◽

Etukudoh Okon Jimmy

Keyword(s):

Growth Retardation ◽

Wistar Rats ◽

Intrauterine Growth Retardation ◽

Intrauterine Growth

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The impact of intrauterine growth retardation on glomerular filtration rate

Zeitschrift für Geburtshilfe und Neonatologie ◽

10.1055/s-2006-943120 ◽

2006 ◽

Vol 210 (S 5) ◽

Author(s):

S Vanhaesebrouck ◽

C Vanhole ◽

F de Zegher ◽

K Allegaert

Keyword(s):

Glomerular Filtration Rate ◽

Glomerular Filtration ◽

Growth Retardation ◽

Filtration Rate ◽

Intrauterine Growth Retardation ◽

Intrauterine Growth ◽

The Impact

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The impact of intrauterine growth retardation on glomerular filtration rate

Zeitschrift für Geburtshilfe und Neonatologie ◽

10.1055/s-2006-946035 ◽

2006 ◽

Vol 210 (S 5) ◽

Author(s):

S Vanhaesebrouck ◽

C Vanhole ◽

F de Zegher ◽

K Allegaert

Keyword(s):

Glomerular Filtration Rate ◽

Glomerular Filtration ◽

Growth Retardation ◽

Filtration Rate ◽

Intrauterine Growth Retardation ◽

Intrauterine Growth ◽

The Impact

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Imbalance in the system L-arginin-NO in pathogenesis of obstetric complications and intrauterine growth retardation (Literature review)

HEALTH OF WOMAN ◽

10.15574/hw.2016.111.43 ◽

2016 ◽

pp. 43-47

Author(s):

O.V. Basystyi ◽

Keyword(s):

Nitric Oxide ◽

Literature Review ◽

Growth Retardation ◽

Intrauterine Growth Retardation ◽

Obstetric Complications ◽

Pathogenetic Role ◽

Intrauterine Growth ◽

System L ◽

Nitric Oxide Deficiency

The data of domestic and foreign literature on etiology, pathogenesis and intrauterine growth retardation diagnosis are presented in the paper. It highlights pathogenetic role of nitric oxide deficiency in case of obstetric complications and intrauterine growth retardation. Key words: intrauterine growth retardation (IUGR), system L-arginin–NO, obstetric complications.

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