scholarly journals Pancreas transplantation: review

2015 ◽  
Vol 13 (2) ◽  
pp. 305-309 ◽  
Author(s):  
Roberto Ferreira Meirelles Júnior ◽  
Paolo Salvalaggio ◽  
Alvaro Pacheco-Silva
Keyword(s):  
Pancreas Transplantation ◽  
Glycosylated Hemoglobin ◽  
The United States ◽  
Diabetes Patient ◽  
Pancreas Transplant ◽  
First Year ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Simultaneous Pancreas Kidney

ABSTRACT Vascularized pancreas transplantation is the only treatment that establishes normal glucose levels and normalizes glycosylated hemoglobin levels in type 1 diabetic patients. The first vascularized pancreas transplant was performed by William Kelly and Richard Lillehei, to treat a type 1 diabetes patient, in December 1966. In Brazil, Edison Teixeira performed the first isolated segmental pancreas transplant in 1968. Until the 1980s, pancreas transplants were restricted to a few centers of the United States and Europe. The introduction of tacrolimus and mycophenolate mofetil in 1994, led to a significant outcome improvement and consequently, an increase in pancreas transplants in several countries. According to the International Pancreas Transplant Registry, until December 31st, 2010, more than 35 thousand pancreas transplants had been performed. The one-year survival of patients and pancreatic grafts exceeds 95 and 83%, respectively. The better survival of pancreatic (86%) and renal (93%) grafts in the first year after transplantation is in the simultaneous pancreas-kidney transplant group of patients. Immunological loss in the first year after transplant for simultaneous pancreas-kidney, pancreas after kidney, and pancreas alone are 1.8, 3.7, and 6%, respectively. Pancreas transplant has 10 to 20% surgical complications requiring laparotomy. Besides enhancing quality of life, pancreatic transplant increases survival of uremic diabetic patient as compared to uremic diabetic patients on dialysis or with kidney transplantation alone.

"Taming the Monster aka Uncontrolled Diabetes: A Viewpoint" (Preprint)

2020 ◽  
Author(s):  
Swati Anand ◽  
Amardeep Kalsi ◽  
Jonathan Figueroa ◽  
Parag Mehta
Keyword(s):  
Blood Glucose ◽  
Diabetes Management ◽  
Positive Impact ◽  
The United States ◽  
Phone Call ◽  
Diabetic Patients ◽  
Dietary Compliance ◽  
Glucose Levels ◽  
Uncontrolled Diabetes ◽  
Number Of Patients

BACKGROUND HbA1c between 6% and 6.9% is associated with the lowest incidence of all‐cause and CVD mortality, with a stepwise increase in all‐cause and cardiovascular mortality in those with an HbA1c >7%. • There are 30 million individuals in the United States (9.4% of the population) currently living with Diabetes Mellitus. OBJECTIVE Improving HbA1C levels in patients with uncontrolled Diabetes with a focused and collaborative effort. METHODS Our baseline data for Diabetic patients attending the outpatient department from July 2018 to July 2019 in a University-affiliated hospital showed a total of 217 patients for one physician. • Of 217 patients, 17 had HbA1C 9 and above. We contacted these patients and discussed the need for tight control of their blood glucose levels. We intended to ensure them that we care and encourage them to participate in our efforts to improve their outcome. • We referred 13 patients that agreed to participate to the Diabetic educator who would schedule an appointment with the patients, discuss their diet, exercise, how to take medications, self-monitoring, and psychosocial factors. • If needed, she would refer them to the Nutritionist based on patients’ dietary compliance. • The patients were followed up in the next two weeks via telemedicine or a phone call by the PCP to confirm and reinforce the education provided by the diabetes educator. RESULTS Number of patients that showed an improvement in HbA1C values: 11 Cumulative decrease in HbA1C values for 13 patients: 25.3 The average reduction in HbA1C: 1.94 CONCLUSIONS Our initiative to exclusively target the blood glucose level with our multidisciplinary approach has made a positive impact, which is reflected in the outcome. • It leads to an improvement in patient compliance and facilitates diabetes management to reduce the risk for complications CLINICALTRIAL NA

Postabsorptive muscle protein metabolism in type 1 diabetic patients after pancreas transplantation

2000 ◽  
Vol 37 (4) ◽  
pp. 219-224 ◽  
Author(s):  
L. Luzi ◽  
L. Piceni Sereni ◽  
M. Spessot ◽  
R. Dodesini ◽  
M.R. Pastore ◽  
...  
Keyword(s):  
Protein Metabolism ◽  
Pancreas Transplantation ◽  
Muscle Protein ◽  
Diabetic Patients ◽  
Muscle Protein Metabolism ◽  
Type 1 Diabetic Patients

scholarly journals Endocrine responses of type 1 (insulin-dependent) diabetic patients following successful pancreas transplantation

Diabetologia ◽  
1983 ◽  
Vol 24 (4) ◽  
Author(s):  
G. Pozza ◽  
J. Traeger ◽  
J.M. Dubernard ◽  
A. Secchi ◽  
A.E. Pontiroli ◽  
...  
Keyword(s):  
Pancreas Transplantation ◽  
Diabetic Patients ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

scholarly journals Increased Plasma Amylin in Type 1 Diabetic Patients After Kidney and Pancreas Transplantation: A sign of impaired  -cell function?

Diabetes Care ◽  
2006 ◽  
Vol 29 (5) ◽  
pp. 1031-1038 ◽  
Author(s):  
M. Stadler ◽  
C. Anderwald ◽  
T. Karer ◽  
A. Tura ◽  
T. Kastenbauer ◽  
...  
Keyword(s):  
Pancreas Transplantation ◽  
Cell Function ◽  
Diabetic Patients ◽  
Type 1 Diabetic Patients

scholarly journals Specific use of CSII during enteral nocturnal nutrition in a child with type 1 diabetes, Hashimoto's thyroiditis, and Down syndrome

2013 ◽  
Vol 57 (5) ◽  
pp. 388-392 ◽  
Author(s):  
Barbara Piccini ◽  
Sonia Toni ◽  
Lorenzo Lenzi ◽  
Federica Barni ◽  
Monica Guasti ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Insulin Therapy ◽  
Enteral Feeding ◽  
Case Reports ◽  
Scientific Evidence ◽  
Nutrition Therapy ◽  
Artificial Nutrition ◽  
Diabetic Patients ◽  
Glucose Levels

The management of insulin therapy in diabetic patients who have comorbidities that involve nutritional aspects, is a major challenge for diabetes care teams. In diabetic patients with compromised nutritional status, artificial nutrition, both enteral or parenteral, may help in the treatment of chronic and acute diseases, leading to better and faster recover of the health status but, if not adequately associated with insulin therapy, it may negatively affect blood glucose levels and lead to poorer metabolic control. In particular, evidence-based recommendations for the treatment of diabetic patients during enteral nutrition therapy are not currently available and, therefore, medical practices are often based on case reports, rather than outcomes of research. We report our experience with a diabetic patient receiving nocturnal enteral feeding due to comorbidities and malnutrition, who was followed up at our centre and precociously treated with continuous subcutaneous insulin infusion after the onset of type 1 diabetes. There is great need for adequately powered randomized controlled trials to provide scientific evidence for the insulin treatment of diabetic patients undergoing enteral feeding.

scholarly journals Active Subjects with Autoimmune Type 1 Diabetes have Better Metabolic Profiles than Sedentary Controls

2017 ◽  
Vol 26 (1) ◽  
pp. 23-32 ◽  
Author(s):  
M. Adamo ◽  
R. Codella ◽  
F. Casiraghi ◽  
A. Ferrulli ◽  
C. Macrì ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 1 Diabetes ◽  
Insulin Pump ◽  
Glycosylated Hemoglobin ◽  
High Volume ◽  
Insulin Pump Therapy ◽  
Pump Therapy ◽  
Glucose Levels ◽  
Nonobese Diabetic Mice

Previous studies in humans with type 1 diabetes mellitus (T1D) and in nonobese diabetic mice have investigated the beneficial immunomodulatory potential of aerobic physical activity. Performing high volume of aerobic exercise may favorably regulate autoimmunity in diabetes. We tested whether increased physical activity is a self-sufficient positive factor in T1D subjects. During a 3-month observational period, active (six males; 40.5 ± 6.1 years; BMI: 24.5 ± 2.1) and sedentary (four males, three females; 35.9 ± 8.9 years; BMI: 25.7 ± 3.8) T1D individuals on insulin pump therapy were studied for metabolic, inflammatory, and autoimmune parameters. At baseline and at the end of a 3-month period, glycosylated hemoglobin (HbA1c), autoantibodies (anti-GAD, anti-ZnT8, anti-IA2, and ICA) and proinflammatory cytokines (IL-6 and TNF-α) were evaluated. During the third month of the period, physically active T1D patients showed a significant reduction in the average glucose levels (-9%, p = 0.025, by CGM) compared to the first month values, and even their hyperglycemic episodes (>180 mg/dl) diminished significantly (-24.2%, p = 0.032 vs. first month). Moreover, active T1D subjects exhibited an improved body composition with respect to sedentary controls. No significant changes were detected as to the autoimmune and inflammatory profiles. This study confirms the beneficial role of physical exercise associated with insulin pump therapy in order to improve metabolic control in individuals with T1D. These preliminary positive observations need to be challenged in a prolonged interventional follow-up.

Kidney-Pancreas Transplantation Is Associated With Near-Normal Sexual Function in Uremic Type 1 Diabetic Patients

2011 ◽  
Vol 92 (7) ◽  
pp. 802-808 ◽  
Author(s):  
Andrea Salonia ◽  
Francesca DʼAddio ◽  
Chiara Gremizzi ◽  
Alberto Briganti ◽  
Federico Dehò ◽  
...  
Keyword(s):  
Sexual Function ◽  
Pancreas Transplantation ◽  
Diabetic Patients ◽  
Type 1 Diabetic Patients
Sign in / Sign up

Export Citation Format

Share Document