Histopathologic findings of pulmonary acariasis in a rhesus monkeys breeding unit

Histological lesions in the lungs of rhesus monkeys (Macaca mulatta) related with Pneumonyssus simicola were evidenced. The most prominent pathologic alterations included numerous thin-walled cysts 1-5 mm diameter scattered throughout the lungs, bronchiolitis, peribronchiolitis where the mites were found associated with pigmented and non-pigmented materials. Our study included data from 347 rhesus monkeys submitted to necropsies during 20 years. Four adult debilitated animals were found with pulmonary acariasis which showed a very low incidence of parasite (1.2%) in the colony. Most of the published literature described as common and widespread pulmonary acariasis in Old World monkeys. The present study confirms the ubiquity of P. simicola in captive born and raised rhesus monkeys that would compromise experimental studies involving the respiratory system.

Download Full-text

Species differences in the aromatization of quinic acid in vivo and the role of gut bacteria

Biochemical Journal ◽

10.1042/bj1160437 ◽

1970 ◽

Vol 116 (3) ◽

pp. 437-443 ◽

Cited By ~ 60

Author(s):

R. H. Adamson ◽

J. W. Bridges ◽

M. E. Evans ◽

R. T. Williams

Keyword(s):

Rhesus Monkey ◽

Rhesus Monkeys ◽

Hippuric Acid ◽

Shikimic Acid ◽

Tree Shrew ◽

Quinic Acid ◽

New World Monkeys ◽

Old World Monkeys ◽

Gut Flora ◽

Old World

1. The fate of (-)-quinic acid has been investigated in 22 species of animals including man. 2. In man and three species of Old World monkeys, i.e. rhesus monkey, baboon and green monkey, oral quinic acid was extensively aromatized (20–60%) and excreted in the urine as hippuric acid, which was determined fluorimetrically. 3. In three species of New World monkeys, i.e. squirrel monkey, spider monkey and capuchin, in three species of lemurs, i.e. bushbaby, slow loris and tree shrew, in the dog, cat, ferret, rabbit, rat, mouse, guinea pig, hamster, lemming, fruit bat, hedgehog and pigeon, oral quinic acid was not extensively aromatized (0–5%). 4. In the rhesus monkey, injected quinic acid was not aromatized, but largely excreted unchanged. 5. In rhesus monkeys pretreated with neomycin to suppress gut flora, the aromatization of oral quinic acid was considerably suppressed. 6. In rats and rhesus monkeys [14C]quinic acid was used and this confirmed its low aromatization in rats and its high aromatization in the monkeys. 7. Shikimic acid given orally was excreted as hippuric acid (26–56%) in rhesus monkeys, but not in rats. 8. The results support the view that quinic acid and shikimic acid are aromatized by the gut flora in man and the Old World monkeys.

Download Full-text

A preliminary survey of the nematode parasites of some imported old-world monkeys

Laboratory Animals ◽

10.1258/002367773780944120 ◽

1973 ◽

Vol 7 (3) ◽

pp. 265-269 ◽

Cited By ~ 5

Author(s):

D. Owen ◽

S. Casillo

Keyword(s):

Macaca Mulatta ◽

Alimentary Tract ◽

Old World Monkeys ◽

Preliminary Survey ◽

Old World ◽

Nematode Parasites ◽

Faecal Samples

Faecal samples and blood films from 3 species of Old-World monkeys, Macaca mulatta, Macaca irus and Papio dogeura, were examined for the presence of nematode parasites. 8 separate groups, a total of 200 animals, were examined within 24 hours of their arrival at the premises of a primate importer. 8 species of nematode were found to be common inhabitants of the alimentary tract, and small numbers of microfilaria were detected in all groups.

Download Full-text

Ultrastructure and analytical microprobe analysis of simian lung mite pigments

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100143249 ◽

1986 ◽

Vol 44 ◽

pp. 324-325

Author(s):

R. W. Cole ◽

J. C. Kim

Keyword(s):

Biomedical Research ◽

Tissue Damage ◽

Microprobe Analysis ◽

Old World Monkeys ◽

Old World ◽

Experimental Animals ◽

The Past ◽

Lung Mite ◽

Mite Infestations ◽

Cardiopulmonary System

In recent years, non-human primates have become indispensable as experimental animals in many fields of biomedical research. Pharmaceutical and related industries alone use about 2000,000 primates a year. Respiratory mite infestations in lungs of old world monkeys are of particular concern because the resulting tissue damage can directly effect experimental results, especially in those studies involving the cardiopulmonary system. There has been increasing documentation of primate parasitology in the past twenty years.

Download Full-text