Hepatoprotective Effects of Aqueous Extract from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes) on α-Amanitin - Induced Liver Injury in Mice

2013 ◽  
Vol 15 (4) ◽  
pp. 383-391 ◽  
Author(s):  
Xin Wu ◽  
Jun Zeng ◽  
Jinsong Hu ◽  
Qiong Liao ◽  
Rong Zhou ◽  
...  
Keyword(s):  
Liver Injury ◽  
Aqueous Extract ◽  
Ganoderma Lucidum ◽  
Medicinal Mushroom ◽  
Hepatoprotective Effects

Anti-inflammatory and Hepatoprotective Effects of Solanum alatum

1995 ◽  
Vol 23 (01) ◽  
pp. 65-69 ◽  
Author(s):  
Chun-Ching Lin ◽  
Wei-Chih Lin ◽  
Shaw-Rong Yang ◽  
Den-En Shieh
Keyword(s):  
Body Weight ◽  
Liver Injury ◽  
Aqueous Extract ◽  
Kupffer Cells ◽  
Inflammatory Infiltration ◽  
Histological Changes ◽  
Hepatoprotective Effects ◽  
Anti Inflammatory

Solanum alatum aqueous extract was investigated on carrageenin-induced edema and on CCl 4-induced liver injury. The extract (100 or 200 mg/kg body weight) exhibited both anti-inflammatory and hepatoprotective activities. The effects were more prominent at the dose of 200 mg/kg. Histological changes such as necrosis, fatty changes, ballooning degeneration, and inflammatory infiltration of lymphocytes and Kupffer cells around the central veins were concurrently improved by treatment with the S. alatum aqueous extract.

Anti-Inflammatory and Hepatoprotective Effects of Ganoderma lucidum Polysaccharides against Carbon Tetrachloride-Induced Liver Injury in Kunming Mice

Pharmacology ◽  
2019 ◽  
Vol 103 (3-4) ◽  
pp. 143-150 ◽  
Author(s):  
Yu-Sheng Chen ◽  
Quan-Zhan Chen ◽  
Zhen-Jiong Wang ◽  
Chun Hua
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Liver Tissue ◽  
Ganoderma Lucidum ◽  
Acute Liver Injury ◽  
Liver Weight ◽  
Inflammatory Factors ◽  
Ganoderma Lucidum Polysaccharides ◽  
Hepatoprotective Effects ◽  
Anti Inflammatory

Background: Ganoderma lucidum Polysaccharides (GLPS) were found to possess various pharmacological properties including anti-inflammatory and hepatoprotective activities. However, the effect and possible mechanism of GLPS treatment on liver injury have not yet been reported. Therefore, this study aimed to explore the potential anti-inflammatory and hepatoprotective effects and possible mechanism of GLPS in carbon tetrachloride (CCl4)-induced acute liver injury mice. Summary: GLPS significantly reduced the activation of NLRP3 inflammasome and improved liver function in liver injury mice. It significantly inhibited CCl4-induced changes of alanine aminotransferase and aspartate aminotransferase activities in serum, as well as nitric oxide synthase (NOS) and cytochrome P450 2E1 (CYP2E1) activities in liver tissue; it also remarkably decreased levels of liver weight and index, total bilirubin, interleukin (IL)-1β, IL-18, IL-6 and tumor necrosis factor-α in serum, as well as malondialdehyde and IL-1β in liver tissue. Protein expression levels of liver NLRP3, ASC, and Caspase-1 were also downregulated, while the glutathione level in liver tissue was remarkably enhanced in GLPS groups compared to that of the model group. Key Message: These results suggested that GLPS may be a potential for the prevention and treatment of acute liver injury with liver inflammation. The possible mechanism may be related to the inhibition of free radical lipid peroxidation, NOS, and CYP2E1 activities and activation of liver inflammatory factors.

Hepatoprotective effects of Ganoderma lucidum peptides against d-galactosamine-induced liver injury in mice

2008 ◽  
Vol 117 (3) ◽  
pp. 415-419 ◽  
Author(s):  
Yanling Shi ◽  
Jie Sun ◽  
Hui He ◽  
Hui Guo ◽  
Sheng Zhang
Keyword(s):  
Liver Injury ◽  
Ganoderma Lucidum ◽  
Hepatoprotective Effects
Sign in / Sign up

Export Citation Format

Share Document