Abrogation of Thioacetamide-Induced Biochemical Events of Hepatic Tumor Promotion Stage by Tannic Acid in Wistar Rats

2007 ◽  
Vol 26 (1) ◽  
pp. 9-20 ◽  
Author(s):  
Sarwat Sultana ◽  
Anuradha Sehrawat
Keyword(s):  
Tannic Acid ◽  
Wistar Rats ◽  
Tumor Promotion ◽  
Hepatic Tumor

scholarly journals Amelioration of 1,2 Dimethylhydrazine (DMH) Induced Colon Oxidative Stress, Inflammation and Tumor Promotion Response by Tannic Acid in Wistar Rats

2012 ◽  
Vol 13 (9) ◽  
pp. 4393-4402 ◽  
Author(s):  
Oday O. Hamiza ◽  
Muneeb U. Rehman ◽  
Mir Tahir ◽  
Rehan Khan ◽  
Abdul Quaiyoom Khan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Tannic Acid ◽  
Wistar Rats ◽  
Tumor Promotion

Tannic Acid Exhibits Adjuvant Activity by Enhancing Humoral and Cell-Mediated Immunity Against BSA as a Protein Antigen

2021 ◽  
Vol 28 ◽  
Author(s):  
Nidia Cabral-Hipólito ◽  
Brenda Sarahí Molina-Ramírez ◽  
Irais Castillo-Maldonado ◽  
Rocío Meza-Velázquez ◽  
Rubén García-Garza ◽  
...  
Keyword(s):  
Tannic Acid ◽  
Wistar Rats ◽  
Lethal Dose ◽  
Peritoneal Macrophages ◽  
Protein Antigen ◽  
Cell Mediated Immunity ◽  
Vaccine Adjuvants ◽  
Adjuvant Activity ◽  
Toxic Dose

Background: Immunization or vaccination is the process of inducing artificial immunity against an antigen taking advantage of the mechanisms of immunological memory. Current vaccines include substances known as adjuvants, which tend to improve the immunogenicity of the antigen, reduce the antigen quantity employed, and boost the immune response in weak responders. Unfortunately, only a few vaccine adjuvants are approved for human use. Objective: Thus, the objective of this study was to investigate the effect of Tannic acid on humoral and cell-mediated immunity against bovine serum albumin (BSA) as a protein antigen in Wistar rats. Method: In order to establish the Tannic acid concentration to test it as an adjuvant, the lethal dose 50 and maximum non-toxic dose were calculated through cytotoxicity and hemolytic assays with J774 A.1 cell line and rat erythrocytes by resazurin reduction method and UV/vis spectrophotometry. Thirty Wistar rats were divided into 5 groups that included two controls without antigen and three treatment groups of adjuvants plus BSA as a protein antigen. The rats were immunized in a 30-day scheme. Blood samples were collected for humoral immunity analysis by means of immunoglobulin quantification, isotyping and antigen-antibody precipitation inhibition analysis. Rat peritoneal macrophages and splenocytes were isolated for cell-mediated immunity analysis by means of nitric oxide quantification from adjuvant stimulated peritoneal macrophages and lymphocytes proliferation assay. Results: Tannic acid was capable of increasing the immunogenicity of the antigen; besides, it was able to stimulate cell-mediated immunity by means of increased lymphocyte proliferation. Moreover, Tannic acid improved the humoral response by means of increased specific antibodies titers. These activities may be attributed to pattern recognition receptors stimulation. Conclusion: Tannic acid was considered biocompatible when tested in vivo because the concentration tested did not show cytotoxicity or hemolytic effect, and there was no detrimental effect observed on the animals’ health. These results show Tannic acid as a promising candidate for vaccine adjuvant.

The effect of tannic acid on the bone tissue of adult male Wistar rats exposed to cadmium and lead

2017 ◽  
Vol 69 (3) ◽  
pp. 131-141 ◽  
Author(s):  
Ewa Tomaszewska ◽  
Piotr Dobrowolski ◽  
Anna Winiarska-Mieczan ◽  
Małgorzata Kwiecień ◽  
Agnieszka Tomczyk ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tannic Acid ◽  
Adult Male ◽  
Wistar Rats ◽  
Male Wistar Rats ◽  
Cadmium And Lead
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