scholarly journals Association between serum vitamin D and severity of liver fibrosis in chronic hepatitis C patients: a systematic meta-analysis

2014 ◽  
Vol 15 (10) ◽  
pp. 900-906 ◽  
Author(s):  
Yue-qiu Luo ◽  
Xiao-xing Wu ◽  
Zong-xin Ling ◽  
Yi-wen Cheng ◽  
Li Yuan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Chronic Hepatitis C Patients

scholarly journals Is there an association between vitamin D and liver fibrosis in patients with chronic hepatitis C?

2017 ◽  
Vol 54 (1) ◽  
pp. 57-59 ◽  
Author(s):  
Kalinca da Silva OLIVEIRA ◽  
Caroline BUSS ◽  
Cristiane Valle TOVO
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Serum Vitamin ◽  
Inflammatory Activity ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Study Results

ABSTRACT BACKGROUND Vitamin D is known for its immunomodulatory, anti-inflammatory and antifibrotic properties, which are quite relevant in the pathogenesis and treatment of many causes of chronic liver disease. OBJECTIVE This study aimed to evaluate the association between serum vitamin D levels and the histopathological findings in patients with chronic hepatitis C virus infection. METHODS Cross-sectional study composed of patients with chronic hepatitis C. All patients underwent vitamin D 25 dosage and anthropometric data analysis. Liver biopsy was performed in a maximum 36-month period before inclusion in the study. RESULTS Of the 74 patients included in the study, 45 (60.8%) were women, mean age was 57.03±9.24 years, and 63 (85.1%) were white. No association was observed between the serum levels of vitamin D and inflammatory activity (P=0.699) nor with the degree of liver fibrosis (P=0.269). CONCLUSION In this study, no association was observed between vitamin D and inflammatory activity, as well as the degree of liver fibrosis, in patients with chronic hepatitis C.

scholarly journals Correlation of serum vitamin D levels with serum levels of alkaline phosphatase.

2019 ◽  
Vol 26 (10) ◽  
pp. 1651-1654
Author(s):  
Momina Haq ◽  
Farzana Salman ◽  
Seher Obaid ◽  
Mohsina Haq ◽  
Ambreen Gul ◽  
...  
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Serum Vitamin ◽  
P Value ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Chronic Hepatitis C Patients

Objectives: To determine whether serum vitamin D levels are correlated with serum levels of alkaline phosphatase or not? Study Design: Case control cross sectional study. Setting: Gastroenterology unit of private teaching hospital in Peshawar. Period: From November 2015-Januaray 2016. Material and Methods: 100 participants meeting the criteria were included in the study. Fifty clinically normal young adults and fifty were non cirrhotic chronic hepatitis C patients were included in the study. Venous blood samples were taken from all the study participants and serum vitamin D levels were determined by Electro-chemiluminescence binding assay (ECLIA) and serum alkaline phosphatase was determined by Photometric Kinetics. Results: patients were divided into two groups on the basis of gender i.e.25 males and 25 females. A correlation between vitamin D and alkaline phosphatase was determined. Alkaline phosphatase was raised in the non cirrhotic chronic hepatitis C patients. Pearson correlation was applied to find out the relation between vitamin D levels and alkaline phosphatase in the two groups which had a significant relationship with a p-value of 0.01. A positive correlation between alkaline phosphatase and parathyroid hormone was found with a p value of <0.0001. Conclusion: In our study alkaline phosphate was considerably increased in chronic hepatitis C patients who might be due to underlying liver disease. In chronic liver disease the hepatocytes swell up and due to damage to the liver parenchyma the level of alkaline phosphatase increases.

scholarly journals Prevalence of Vitamin D deficiency in patients of Chronic Hepatitis C.

2020 ◽  
Vol 27 (01) ◽  
pp. 35-39
Author(s):  
Najib Ul Haq ◽  
Momina Haq ◽  
Farzana Salman ◽  
Mohsina Haq ◽  
Munaza Khattak ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Vitamin D Deficiency ◽  
Chronic Hepatitis C ◽  
Serum Vitamin ◽  
P Value ◽  
Vitamin D Levels ◽  
Study Population ◽  
Chronic Hepatitis C Patients

Objectives: To determine and compare vitamin D status in chronic hepatitis C patients and normal healthy matching controls. Study Design: A case control study. Setting: A private clinic of Peshawar. Period: 1st November 2015 to 31st January 2016. Material & Methods: Fifty clinically normal young adults and fifty non cirrhotic chronic hepatitis C patients were included in the study. Vitamin D was determined by electro chemiluminescence. Student t test was used to analyze the data in SPSS version 21. Results: The mean age of the study population was 30.68+ 5. Vitamin D deficiency was divided into three categories. 21% of the study population had severe vitamin D deficiency, 33% had mild to moderate deficiency and 46% of the study population had normal levels. Females population were more vitamin D deficient as compared to males (p-value<0.05). Vitamin D levels were comparatively decreased in the non cirrhotic chronic hepatitis C patients. Statistically significant (p value <0.05) results were obtained while comparing means of serum vitamin D of non-cirrhotic chronic hepatitis C patients with healthy matching controls. Conclusion: It is concluded from this study that a significant number of apparently healthy individual have low vitamin D level and some even fall in the severely deficient group without any active complains. Patients with chronic hepatitis C had rather increased levels of vitamin D as compared to normal healthy adults There might be some genetic factors underlying which affects the availability of Vitamin D.

scholarly journals Relationship of serum vitamin D with hepatic fibrosis in patients with chronic hepatitis C

2020 ◽  
Vol 8 (10) ◽  
pp. 3618
Author(s):  
Manas Kumar Behera ◽  
Surendra Nath Swain ◽  
V. B. Abhilash ◽  
Sunit Kumar Shukla ◽  
Vinod Kumar Dixit
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Chronic Hcv ◽  
Negative Predictor ◽  
Age And Sex

Background: Serum vitamin D concentration is proposed to have an important role on outcome in patients with chronic hepatitis C virus (HCV) infection. A few studies have shown an inverse association of vitamin D level with stage of fibrosis. The aim of the present study was to verify whether serum vitamin D level is an independent predictor of significant hepatic fibrosis.Methods: Seventy-two treatment naive chronic HCV subjects and 40 healthy age and sex matched controls were included in the study. A serum vitamin D level was assessed in both HCV subjects and controls, and liver biopsy was performed in all HCV subjects to assess for stage of fibrosis.Results: Serum vitamin D levels were significantly lower HCV patients in comparison to age and sex matched controls (18.04±6.92 versus 21.53±8.2, p<0.01). Most common genotype in HCV patients was genotype 3 (62.5%) and blood transfusion was the most common mode of transmission (28%) followed by intravenous drug user (IVDU) (17%). The HCV patients with vitamin D level <20 ng/ml had higher metavir score as compared to vitamin D≥20 ng/ml (1.67±0.66 versus 2.5±0.67, p<0.001). Both univariate and multivariate analysis performed using logistic regression revealed that vitamin D<20 ng/dl is a significant negative predictor of liver fibrosis (p<0.05).Conclusions: Chronic HCV patients had significantly lower vitamin D levels as compared to healthy controls. Serum vitamin D was a negative predictor of stage of fibrosis in patients with chronic hepatitis C.

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