THE MEASUREMENT OF OXYGEN CONSUMPTION IN SMALL ANIMALS BY A CLOSED CIRCUIT METHOD

1950 ◽  
Vol 6 (4) ◽  
pp. 456-NP ◽  
Author(s):  
N. F. MACLAGAN ◽  
MARY M. SHEAHAN
1975 ◽  
Vol 39 (5) ◽  
pp. 849-850 ◽  
Author(s):  
M. J. Stock

An apparatus suitable for the continuous measurement of oxygen consumption of rats and mice is described. The system uses a motorized syringe dispenser to deliver fixed volumes of oxygen to a closed animal chamber. The dispenser is controlled by a micro-differential pressure switch to maintain chamber pressure slightly above ambient. The rate of oxygen consumption is determined by timing the interval between successive operations of the dispenser. The system has proved suitable for a range of experimental conditions and treatments.


PEDIATRICS ◽  
1964 ◽  
Vol 33 (4) ◽  
pp. 554-561
Author(s):  
Fernando Mönckeberg ◽  
Francisco Beas ◽  
Isidoro Horwitz ◽  
Alfredo Dabancens ◽  
Margarita González

Oxygen consumption was determined with a closed circuit apparatus in 52 normal infants and 22 marasmatic infants. Oxygen consumption in marasmatic infants was similar to that of the normal ones when expressed in relation to the actual weight, but was significantly lower if expressed in regard to height. The lower values were observed in marasmatic infants before recovery started (Group B), while those marasmatics that had started recovery (Group A), showed intermediate values between that of the normal infants and Group B. The significance of these results has been discussed.


1961 ◽  
Vol 16 (5) ◽  
pp. 923-925 ◽  
Author(s):  
John Haldi ◽  
Winfrey Wynn ◽  
Harold Breding

1959 ◽  
Vol 38 (4) ◽  
pp. 899-902 ◽  
Author(s):  
Lowell W. Charkey ◽  
Paul A. Thornton

2004 ◽  
Vol 99 (1) ◽  
pp. 306
Author(s):  
Antonio González-Arévalo ◽  
Juan I. Gómez-Arnau ◽  
Santiago García-del-Valle

1960 ◽  
Vol 15 (3) ◽  
pp. 359-362 ◽  
Author(s):  
G. Milic-Emili ◽  
J. M. Petit

Simultaneous measurements of mechanical work and energy cost of breathing were performed on four normal subjects with ventilation increased by adding dead space. Mechanical work was obtained from simultaneous records of endoesophageal pressure and tidal volume. The associated energy cost was estimated by measuring oxygen consumption of respiratory muscles by means of a closed-circuit spirometer. In all subjects studied and over the range of ventilations involved (ca. 30–110 l/min.), the mechanical efficiency of breathing was found to be in the order of 0.19–0.25. Submitted on July 6, 1959


1942 ◽  
Vol 19 (2) ◽  
pp. 168-175
Author(s):  
R. J. WHITNEY

1. A size factor is demonstrated for the oxygen consumption at 14.5° C. of four species of fresh-water Turbellaria obtained from different habitats. 2. For three of the species studied (Polycelis cornuta, Crenobia alpina and Planaria polychroa) small animals were found to have a higher oxygen consumption per unit weight than large ones. In the case of Polycelis nigra small animals were shown to have a lower oxygen consumption per unit weight than large ones. 3. The adherence of the size factor to the surface law of Rubner is discussed. Only Crenobia alpina satisfies the theoretical requirements of the law, and in this species it is shown that the size factor is practically unchanged when the oxygen consumptions are determined at 7.0° C. instead of 14.5° C.


Author(s):  
John R. B. Lighton

This chapter describes the theory and practical applications of coulometric respirometry. Coulometric respirometry is probably the most accurate method for measuring oxygen consumption rates. It is ideal for small animals and has the dual advantages of high sensitivity and the fact that the oxygen in the organism’s environment is not depleted, allowing measurements to continue for long periods in many cases. The technique works by maintaining a constant pressure in a sealed system by electrolytically producing oxygen at the same rate at which an enclosed organism consumes it.


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