URINARY EXCRETION OF PREGNANEDIOL IN POST-MENOPAUSAL WOMEN AND MEN DURING PROLONGED DAILY ADMINISTRATION OF PROGESTERONE

1954 ◽  
Vol 10 (4) ◽  
pp. 351-357 ◽  
Author(s):  
G. F. MARRIAN ◽  
MARGARET E. RUSSELL ◽  
SHELIA M. ATHERDEN
Keyword(s):  
Urinary Excretion ◽  
Intramuscular Injection ◽  
Daily Administration ◽  
Menopausal Woman ◽  
Marked Contrast ◽  
Post Menopausal Woman ◽  
Menopausal Women ◽  
Post Menopausal

SUMMARY Progesterone (50 mg/day) was administered by intramuscular injection to six intact post-menopausal women and to one man for periods of 13–20 days, and by mouth to one intact post-menopausal woman for 15 days. Determinations of the daily urinary excretion of pregnanediol by these subjects gave results in marked contrast to those of Sommerville & Marrian [1950].

On the mechanism of action of progestins

1981 ◽  
Vol 97 (3) ◽  
pp. 320-328 ◽  
Author(s):  
Gregorio Pérez-Palacios ◽  
María A. Fernández-Aparicio ◽  
Martha Medina ◽  
Jesús Zacarías-Villareal ◽  
Alfredo Ulloa-Aguirre
Keyword(s):  
Menopausal Woman ◽  
Base Line ◽  
Continuous Administration ◽  
Post Menopausal Woman ◽  
Menopausal Women ◽  
Vaginal Rings ◽  
Differing Effect ◽  
Post Menopausal ◽  
Insight Into ◽  
Natural Progesterone

Abstract. The effect of two synthetic injectable progestins, norethisterone oenanthate3 (NET-e) and medroxyprogesterone acetate (MPA) upon the hypothalamic pituitary unit was evaluated in post-menopausal women (PMW) and in castrated individuals with androgen un-responsiveness in order to gain insight into their mechanism of gonadotrophin inhibition. Continuous administration of natural progesterone (P4) to PMW by medicated vaginal rings was used as the experimental control. Elevated base line levels of serum immunoreactive gonadotrophins and normal pituitary LRH responses were found in PMW and pseudohermaphrodites. Progesterone did not affect circulating gonadotrophin levels or the pituitary LRH response in PMW. Administration of MPA 150 mg induced a clear decrease in serum gonadotrophins and a significant decrease in LRH pituitary responsiveness in a post-menopausal woman whereas no effect was observed on serum gonadotrophins and pituitary response to LRH in a patient with androgen unresponsiveness. Administration of NET-e 200 mg resulted in a significant decrease in circulating gonadotrophins in PMW and pseudohermaphrodites, while LRH pituitary sensitivity was diminished in all subjects except one post-menopausal woman. These results demonstrated that two structurally different synthetic progestins (NET-e and MPA) had a potent gonadotrophin inhibitory activity in PMW while natural progesterone did not, thus indicating a different mode of action. Furthermore their differing effect on individuals with complete androgen unresponsiveness suggested that antigonadotrophic activity of NET-e is mediated by its oestrogenic-progestational effect, while MPA acts through its androgenic potency and therefore requires the presence of androgen receptors.

THE INDUCTION OF WITHDRAWAL BLEEDING WITH QUINESTRADOL (PENTOVIS) IN SPAYED MONKEYS, AND SOME OBSERVATIONS ON ITS EXCRETION AND THAT OF OESTRIOL IN THE URINE

1967 ◽  
Vol 37 (3) ◽  
pp. 239-NP ◽  
Author(s):  
P. ECKSTEIN ◽  
MARION GREIG ◽  
W. R. BUTT
Keyword(s):  
Genital Tract ◽  
Biological Effects ◽  
Menopausal Woman ◽  
Marked Contrast ◽  
Post Menopausal Woman ◽  
Withdrawal Bleeding ◽  
Lower Genital Tract ◽  
Post Menopausal ◽  
Uterine Haemorrhage ◽  
Daily Oral Administration

SUMMARY 1. Daily oral administration of between 0·1 and 0·5 mg. quinestradol (3-cyclopentyl ether of oestriol) for 14 days to four spayed monkeys induced macroscopic uterine haemorrhage in three and microscopic bleeding in the fourth. This is in marked contrast to the finding that in women this compound seems to act only on the lower genital tract and does not cause uterine withdrawal bleeding. Oestriol, given in the same way at a daily dosage of 0·82 mg., also induced withdrawal bleeding in one monkey. 2. The urinary excretion of quinestradol and oestriol was studied in two of the monkeys and that of quinestradol alone in a post-menopausal woman. The findings indicate that some quinestradol is excreted as oestriol, which in monkeys, unlike women, appears to be unconjugated. 3. Possible reasons for the observed differences in the biological effects of quinestradol in the two species are briefly discussed.

scholarly journals Yolk sac tumor of the endometrium in a post-menopausal woman: Case report and review of the literature

2021 ◽  
pp. 100748
Author(s):  
Risha Sinha ◽  
Bethany Bustamante ◽  
Alexander Truskinovsky ◽  
Gary L. Goldberg ◽  
Karin K. Shih
Keyword(s):  
Case Report ◽  
Yolk Sac ◽  
Yolk Sac Tumor ◽  
Menopausal Woman ◽  
Review Of The Literature ◽  
Post Menopausal Woman ◽  
Post Menopausal

Estrogen Replacement Therapy: The Benefit Outweighs the Risk

1993 ◽  
Vol 6 (5) ◽  
pp. 211-215
Author(s):  
Andrea O. Moore ◽  
Geneva C. Briggs
Keyword(s):  
Replacement Therapy ◽  
Estrogen Replacement Therapy ◽  
Menopausal Woman ◽  
Estrogen Replacement ◽  
Post Menopausal Woman ◽  
Long Term Effect ◽  
Increased Risk ◽  
Mortality Incidence ◽  
Post Menopausal ◽  
Multiple Symptoms

Menopause and the related decline in estrogen result in multiple symptoms including genitourinary atrophy, vasomotor instability, and osteoporosis. The most significant long-term effect of estrogen deficiency is increased risk of cardiovascular disease. Estrogen replacement therapy (ERT) decreases osteoporosis and associated fractures, decreases symptoms associated with menopause, and offers cardioprotection. However, ERT is not without risk because it may lead to increased risk of endometrial cancer if used without progestin, and has been questionably linked to breast cancer. Educating the post-menopausal woman concerning the risks and benefits of ERT is essential to assure compliance. ERT decreases mortality incidence and improves quality of life, and its use for any post-menopausal woman without contraindications is recommended.

scholarly journals Endometrioma mimicking ovarian malignancy in a post-menopausal woman

2021 ◽  
Vol 10 (8) ◽  
pp. 3226
Author(s):  
Vijay Zutshi ◽  
Shreshtha Gupta ◽  
Charanjeet Ahluwalia ◽  
Monica R.
Keyword(s):  
Normal Serum ◽  
Reproductive Age ◽  
Ca 125 ◽  
Menopausal Woman ◽  
Ovarian Malignancy ◽  
Ovarian Endometriosis ◽  
Post Menopausal Woman ◽  
Estrogen Production ◽  
Malignant Ovarian Tumor ◽  
Post Menopausal

Endometriosis is an estrogen dependant disorder of reproductive-age women. It is uncommon after menopause, however, peripheral estrogen production may account for endometriosis in post-menopausal women. We reported a case of a 68 year old post-menopausal woman with an adnexal mass suspected malignant ovarian tumor on imaging and normal serum CA 125 levels. Total hysterectomy with bilateral salpingo-oophorectomy was done. The final histopathology revealed the diagnosis of ovarian endometriosis. Rarely, ovarian endometrioma can mimic ovarian malignancy in a post-menopausal woman.

scholarly journals Towards uterine inversion: Illustration of a gradual process through three cases of submucous myoma

1970 ◽  
Vol 1 (2) ◽  
pp. 51-54
Author(s):  
Kesang D Bista ◽  
Ashma Rana ◽  
Geeta Gurung ◽  
Neelam Pradhan ◽  
Archana Amatya
Keyword(s):  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Menopausal Woman ◽  
Post Menopausal Woman ◽  
Submucous Myoma ◽  
Uterine Inversion ◽  
Gradual Process ◽  
Post Menopausal ◽  
Uterine Fundus ◽  
Vaginal Myomectomy

How the largest of the large (> 10 x 8 cms) sub mucous myoma arising from the fundus uteri successively promotes the occurrence of non puerperal uterine inversion over the years as depicted through 3 different illustrations imitating a gradual process; first by forming an indentation in the uterine fundus then progressively causing more dimpling in the verge of uterine inversion until finally giving rise to a full blown picture of complete uterine inversion where the uterine fundus is driven beyond the level of introitus with the consequences of prolapsed incarcerated myoma in a post menopausal woman. A total abdominal hysterectomy and bilateral salpingoophorectomy were performed on all of these 3 women 2 perimenopausal and a postmenopausal; the latter was first facilitated by vaginal myomectomy further supplemented by division of the inversion ring posteriorly as described by Haultain. Key words: Non puerperal uterine inversion, submucous fundal myoma, vaginal myomectomy. doi:10.3126/njog.v1i2.2398 N. J. Obstet. Gynaecol Vol. 1, No. 2, p. 51-54 Nov-Dec 2006

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