CONGENITAL ADRENAL HYPERPLASIA AND OTHER CONDITIONS ASSOCIATED WITH A RAISED URINARY STEROID 11-OXYGENATION INDEX

1971 ◽  
Vol 50 (2) ◽  
pp. 251-265 ◽  
Author(s):  
BARBARA E. CLAYTON ◽  
R. W. H. EDWARDS ◽  
H. L. J. MAKIN
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Adrenal Hyperplasia ◽  
Congenital Heart ◽  
Oxygenation Index ◽  
Adrenocortical Function ◽  
Adrenal Hyperplasia ◽  
Severe Diarrhoea ◽  
Adrenocortical Tumours ◽  
Urinary Steroid

SUMMARY Raised values of the 11-oxygenation index (11-OI) were found in 164 children, although it was only possible to record 97 fully. Seventy-four were fully diagnosed as having congenital adrenal hyperplasia (CAH) and among the others five had high 11-OI values which fell to normal by the 8th day of life and two gave high values due to methodological interference by 1-oxygenated steroids. Severe diarrhoea was associated with a raised 11-OI in ten boys and this presented difficulty in diagnosis; CAH was considered a possible diagnosis by the referring physician but was finally excluded. Impaired adrenocortical function probably accounted for the raised 11-OI observed in six children who were never considered to have CAH. They had a variety of conditions including congenital heart disease. Normal 11-OI values were found in six patients with adrenocortical tumours. Prednisone and prednisolone administration interfered with the determination.

scholarly journals Feasibility and effectiveness of prone position ventilation technique for postoperative acute lung injury in infants with congenital heart disease: study protocol for a prospective randomized study

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yu-lu Xu ◽  
Ya-ping Mi ◽  
Meng-xin Zhu ◽  
Yue-hong Ren ◽  
Wei-juan Gong ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Prone Position ◽  
Congenital Heart ◽  
Controlled Trial ◽  
Randomized Study ◽  
Oxygenation Index ◽  
Control Group

Abstract Background Prone position ventilation is a widely used lung protection ventilation strategy. The strategy is more convenient to implement in children compared to adults. Due to the precise mechanism of improving oxygenation function, development of pediatric prone ventilation technology has been largely focused on children with acute respiratory distress syndrome. There is a paucity of high-quality studies investigating the effects of prone position ventilation after pediatric cardiac surgery. The purpose of this study is to evaluate the feasibility and effectiveness of prone position ventilation in infants who develop postoperative acute lung injury after surgery for congenital heart disease. Methods A single-center, randomized controlled trial of pediatric patients with acute lung injury after surgery for congenital heart disease who will receive prone position ventilation or usual care (control group). A total of 68 children will be enrolled according to the inclusion criteria. The main outcome measures will be lung compliance and oxygenation index. The secondary outcomes will be duration of mechanical ventilation, length of stay in cardiac intensive care unit, reintubation rate, and complication rate. Discussion This study will investigate the feasibility and effectiveness of prone position ventilation techniques in children who develop postoperative acute lung injury after surgery for congenital heart disease. The results may help inform strategies to improve airway management after surgery for congenital heart disease. Trial registration ClinicalTrials.gov NCT04607993. Initially registered on 29 October 2020.

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