VASOTOCIN RELEASE INTO THE CEREBROSPINAL FLUID OF CATS INDUCED BY LUTEINIZING HORMONE RELEASING HORMONE, THYROTROPHIN RELEASING HORMONE AND GROWTH HORMONE RELEASE-INHIBITING HORMONE

1977 ◽  
Vol 75 (1) ◽  
pp. 175-176 ◽  
Author(s):  
R. GOLDSTEIN ◽  
S. PAVEL
Keyword(s):  
Growth Hormone ◽  
Cerebrospinal Fluid ◽  
Luteinizing Hormone ◽  
Pineal Gland ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Thyrotrophin Releasing Hormone ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Lh Rh

Institute of Endocrinology, Bucharest, Rumania (Received 29 March 1977) The mammalian pineal gland contains (Pavel, 1965) and synthesizes (Pavel, Goldstein, Ghinea & Calb, 1977) the nonapeptide arginine-vasotocin (AVT). Since luteinizing hormone releasing hormone (LH–RH), thyrotrophin releasing hormone (TRH) and growth hormone release-inhibiting hormone (somatostatin, SRIF) have now been localized not only in the brain, but also in the pineal gland (White, Hedlund, Weber, Rippel, Johnston & Wilber, 1974; Pelletier, Le Clerc, Dube, Labrie, Puviani, Arimura & Schally, 1975), we investigated the effects of these peptides on the release of AVT into the cerebrospinal fluid (CSF) of cats. Intracarotid injections of 0·1 μg LH-RH, TRH (Hoechst, Frankfurt), SRIF (Serono, Rome) or oxytocin (Syntocinon, Sandoz Ltd, Basel) in 0·5 ml saline were given to urethane-anaesthetized male cats weighing 3–4 kg. Controls received an equal volume of saline only. The pineal glands were removed 60 min after the injections, quickly homogenized, and extracted

scholarly journals Stimulation of growth hormone release by luteinizing hormone-releasing hormone in two males with isolated gonadotropin deficiency.

1976 ◽  
Vol 23 (5) ◽  
pp. 383-390
Author(s):  
KANJI KASAGI ◽  
MARIKO OISHI ◽  
MITSUSHIGE NISHIKAWA ◽  
SHUNICHIRO KURATA ◽  
MITSUO INADA ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Luteinizing Hormone ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Gonadotropin Deficiency ◽  
Stimulation Of

Tri-iodothyronine inhibition of thyrotrophin-releasing hormone-induced growth hormone release from the chicken adenohypophysis in vitro

1990 ◽  
Vol 126 (1) ◽  
pp. 75-81 ◽  
Author(s):  
S. Harvey
Keyword(s):  
Growth Hormone ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Direct Effects ◽  
Thyrotrophin Releasing Hormone ◽  
Releasing Hormone ◽  
Gh Secretion ◽  
Site Of Action

ABSTRACT Tri-iodothyronine (T3) had no effect on the basal level of GH release from chicken hemipituitary glands perifused in vitro. The GH response to TRH was, however, markedly suppressed following exposure to T3. Suppression of TRH-stimulated GH secretion was observed after a 2-h preincubation with T3, and was induced, in a dose-related way, by 0·01–10 μmol T3/l. Exposure to T3 also reduced the effectiveness of TRH, at concentrations of 0·001–10 μg/ml, to stimulate GH release. These results demonstrate that, in addition to a hypothalamic site of action, T3 is likely to suppress GH secretion in vivo by direct effects on pituitary GH release. Journal of Endocrinology (1990) 126, 75–81

APPLICATION OF AN IN-VITRO PERIFUSION TECHNIQUE TO STUDIES OF LUTEINIZING HORMONE RELEASE BY RAT ANTERIOR HEMI-PITUITARIES: SELF-POTENTIATION BY LUTEINIZING HORMONE RELEASING HORMONE

1976 ◽  
Vol 68 (2) ◽  
pp. 197-207 ◽  
Author(s):  
J. A. EDWARDSON ◽  
D. GILBERT
Keyword(s):  
Luteinizing Hormone ◽  
Priming Effect ◽  
Hormone Release ◽  
Physiological Control ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Hypothalamic Extract ◽  
Lh Rh ◽  
Lh Secretion

SUMMARY A technique is described for the continuous perifusion of rat adenohypophyses. Exposure of the perifused glands to repeated equal 5 min stimuli with hypothalamic extract resulted in a series of equal peaks of corticotrophin secretion, the response was proportional to log dose over the range 0·25–2·0 rat hypothalamic equivalents/ml. Repeated equal stimuli with hypothalamic extract, or with luteinizing hormone releasing hormone (LH-RH) at concentrations of 2 or 10 ng/ml, resulted in a progressively increasing series of peaks of LH secretion, i.e. a self-potentiating or priming effect. The effect took between 30 min and 1 h to develop. A delayed increase in the responsiveness of the glands was also seen with continuous incubation of anterior pituitaries with LH-RH. The relevance of these observations to the physiological control of LH secretion is discussed.

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