PLASMA CONCENTRATIONS OF GROWTH HORMONE DURING GROWTH IN NORMAL AND TESTOSTERONE-TREATED CHICKENS

1978 ◽  
Vol 79 (1) ◽  
pp. 145-146 ◽  
Author(s):  
S. HARVEY ◽  
C. G. SCANES
Keyword(s):  
Growth Hormone ◽  
New Jersey ◽  
New Brunswick ◽  
Plasma Concentrations ◽  
High Plasma ◽  
Gh Secretion ◽  
Rutgers University ◽  
Definite Pattern ◽  
Low Levels ◽  
Experimental Modification

Department of Zoology, University of Hull, Hull, HU6 7RX and * Department of Physiology, Rutgers University, New Brunswick, New Jersey 08903, U.S.A. (Received 9 May 1978) Recent avian studies (Harvey, Godden & Scanes, 1977; Harvey, Scanes, Falconer, Bolton & Chadwick, 1977) have established a definite pattern of growth hormone (GH) secretion during growth, with high plasma concentrations in young growing birds and low levels in adults. These observations indicate that the concentration of immunoreactive GH in the circulation may be related to the rate of body growth. The aim of the present study was, therefore, to determine whether experimental modification of growth was accompanied by corresponding alterations in GH secretion. Since testosterone suppresses growth in cockerels (Visco, 1973), plasma concentrations of GH were determined during growth in control and testosterone-implanted birds. Seven 2-week-old cockerels (Thornber 909 strain) were implanted subcutaneously with a testosterone pellet (Intervet, 100 mg) in the nape

EFFECT OF RESERPINE ON PLASMA CONCENTRATIONS OF GROWTH HORMONE AND PROLACTIN IN THE DOMESTIC FOWL

1978 ◽  
Vol 79 (1) ◽  
pp. 153-154 ◽  
Author(s):  
S. HARVEY ◽  
C. G. SCANES ◽  
A. CHADWICK ◽  
N. J. BOLTON
Keyword(s):  
Growth Hormone ◽  
New Jersey ◽  
New Brunswick ◽  
Biogenic Amines ◽  
Domestic Fowl ◽  
Plasma Concentrations ◽  
Prolactin Secretion ◽  
Peripheral Plasma ◽  
Rutgers University

Department of Zoology, University of Hull, Hull, HU6 7RX, * Department of Physiology, Rutgers University, New Brunswick, New Jersey 08903, U.S.A. and †Department of Pure and Applied Zoology, University of Leeds, Leeds, LS2 9JT (Received 9 June 1978) It has been established that biogenic amines are involved in control of the secretion of prolactin (MacLeod, 1976) and growth hormone (GH; Martin, 1976) in mammals. In birds there is very little evidence for this, although in the domestic fowl it has recently been demonstrated that sytemically administered catecholamines (adrenaline and noradrenaline) markedly lower the concentration of GH in the peripheral plasma (Harvey & Scanes, 1978) and that serotonin stimulates the release of prolactin from incubated hemipituitary glands (Border & Chadwick, 1977). Therefore, to elucidate further the possible involvement of biogenic amines in the regulation of GH and prolactin secretion, the effect of reserpine (a 5-hydroxytryptamine- and catecholamine-depleting agent) on the concentrations

Is there a place for urinary growth hormone measurement?

1993 ◽  
Vol 128 (3) ◽  
pp. 197-201 ◽  
Author(s):  
Maria N Moreira-Andrés ◽  
Francisco J Cañizo ◽  
Federico Hawkins
Keyword(s):  
Growth Hormone ◽  
Screening Method ◽  
Small Sample ◽  
Point Of View ◽  
Intrasubject Variability ◽  
Gh Secretion ◽  
Lack Of Information ◽  
Low Levels ◽  
Plasma Gh ◽  
Serum Gh

The evaluation of growth hormone (GH) secretion is an important problem in pediatric endocrine practice. The diagnosis of GH insufficiency is based on the finding of a "blunted" GH response to GH provocative tests or on the demonstration of a decreased endogenous secretion. From a practical point of view, these methods are uncomfortable, expensive and time consuming. Recently, very sensitive specific assays to measure human GH in urine have been developed. We present a discussion of available data on these tests in order to estimate their role in the evaluation of a short or slowly growing child. The present available assays allow measuring very low levels of GH in a small sample of untreated urine. The main limitations of urinary GH measurement are the intrasubject variability, wide normal range, overlapping results in several GH secretory states and lack of information on GH pulsatility. However, most of these limitations also apply to other tests of GH secretion. The advantage of urinary GH tests is that they provide, in an easy procedure, information on serum GH concentration. There is good correlation between urinary and serum GH concentration and several findings suggest that urinary GH excretion reflects changes in plasma GH levels during the period of urine collection. Therefore, the usefulness of urinary GH measurement is that of a simpler and cheaper screening method for assessing integrated serum GH concentration in clinical practice.

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