Putative aromatase inhibitor induces male sex determination in a female unisexual lizard and in a turtle with temperature-dependent sex determination

1994 ◽  
Vol 141 (2) ◽  
pp. 295-299 ◽  
Author(s):  
T Wibbels ◽  
D Crews
Keyword(s):  
Sex Determination ◽  
Aromatase Inhibitor ◽  
Sexual Differentiation ◽  
Trachemys Scripta ◽  
Aromatase Activity ◽  
Temperature Dependent ◽  
Endogenous Production ◽  
Diverse Species ◽  
Male Sex ◽  
Cnemidophorus Uniparens

Abstract Treatment of developing embryos of two diverse species of reptiles with fadrozole (a potent and specific nonsteroidal inhibitor of aromatase activity in mammals) resulted in the induction of male sex determination. In the first experiment, males were produced in an all-female parthenogenic species of lizard (Cnemidophorus uniparens). In the second experiment, male sex determination was induced in a turtle (Trachemys scripta) with temperature-dependent sex determination. The results support the hypothesis that the endogenous production of oestrogen may represent a pivotal step in the sex determination cascade of reptiles. Further, the production of male C uniparens indicates that the genes required for male sexual differentiation have not been lost in this parthenogenic lizard. Journal of Endocrinology (1994) 141, 295–299

scholarly journals Genetic network underlying temperature-dependent sex determination is endogenously regulated by temperature in isolated cultured Trachemys scripta gonads

2010 ◽  
Vol 239 (4) ◽  
pp. 1061-1075 ◽  
Author(s):  
Christina M. Shoemaker-Daly ◽  
Kyle Jackson ◽  
Ryohei Yatsu ◽  
Yuiko Matsumoto ◽  
David Crews
Keyword(s):  
Sex Determination ◽  
Genetic Network ◽  
Trachemys Scripta ◽  
Temperature Dependent

Intraspecific genome size variation in a turtle (Trachemys scripta) exhibiting temperature-dependent sex determination

1991 ◽  
Vol 69 (9) ◽  
pp. 2306-2310 ◽  
Author(s):  
Samuel F. Lockwood ◽  
Brenden S. Holland ◽  
John W. Bickham ◽  
Brian G. Hanks ◽  
James J. Bull
Keyword(s):  
Sex Ratio ◽  
Sex Determination ◽  
Genome Size ◽  
Incubation Temperature ◽  
Size Variation ◽  
Developmental Rate ◽  
Trachemys Scripta ◽  
Temperature Dependent ◽  
Genome Size Variation ◽  
Different Temperatures

Variation in genome size within and among populations of the pond slider, Trachemys scripta, a species with temperature-dependent sex determination, was investigated. Because genome size has been shown to affect developmental rate in various organisms, as does incubation temperature, it was hypothesized that genome size could influence sex determination in species with environmental sex determination. Significant variation in DNA content was found between geographic populations and among clutches. No significant differences in mean genome size were observed among samples incubated at different temperatures or between sexes of turtles hatched at a temperature that yields a mixed sex ratio. Thus, it appears that sex determination in T. scripta is accomplished in the absence of sex-specific and incubation-temperature-specific differences in genome size. Preliminary data from two populations, however, suggest that genome size may be significantly correlated with the threshold incubation temperature at which a mixed sex ratio is produced.

MALE SEX DETERMINATION: Current Concepts of Male Sexual Differentiation

1994 ◽  
Vol 45 (1) ◽  
pp. 505-524 ◽  
Author(s):  
Michael L. Gustafson, M.D ◽  
Patricia K. Donahoe, M.D
Keyword(s):  
Sex Determination ◽  
Sexual Differentiation ◽  
Male Sex
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