scholarly journals Establishing the Role of Angiotensin-Converting Enzyme in Renal Function and Blood Pressure Control through the Analysis of Genetically Modified Mice

2005 ◽  
Vol 16 (3) ◽  
pp. 583-591 ◽  
Author(s):  
Kenneth E. Bernstein ◽  
Hong D. Xiao ◽  
Jon W. Adams ◽  
Kristen Frenzel ◽  
Ping Li ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Angiotensin Converting Enzyme ◽  
Blood Pressure Control ◽  
Genetically Modified ◽  
Pressure Control ◽  
Converting Enzyme ◽  
Genetically Modified Mice

scholarly journals New insights into the role of angiotensin-converting enzyme obtained from the analysis of genetically modified mice

2008 ◽  
Vol 86 (6) ◽  
pp. 679-684 ◽  
Author(s):  
Xiao Z. Shen ◽  
Hong D. Xiao ◽  
Ping Li ◽  
Chentao X. Lin ◽  
Sandrine Billet ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Genetically Modified ◽  
Converting Enzyme ◽  
Genetically Modified Mice

scholarly journals Angiotensin-converting enzyme overexpression in myelocytes enhances the immune response

2014 ◽  
Vol 395 (10) ◽  
pp. 1173-1178 ◽  
Author(s):  
Kenneth E. Bernstein ◽  
Romer A. Gonzalez-Villalobos ◽  
Jorge F. Giani ◽  
Kandarp Shah ◽  
Ellen Bernstein ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Immune Response ◽  
Renal Function ◽  
Alzheimer Disease ◽  
Angiotensin Converting Enzyme ◽  
Pressure Control ◽  
Converting Enzyme ◽  
Monocytic Cells ◽  
Effective Immune Response ◽  
Enzyme Overexpression

Abstract Angiotensin-converting enzyme (ACE) plays an important role in blood pressure control. ACE also has effects on renal function, reproduction, hematopoiesis, and several aspects of the immune response. ACE 10/10 mice overexpress ACE in monocytic cells; macrophages from ACE 10/10 mice demonstrate increased polarization toward a proinflammatory phenotype. As a result, ACE 10/10 mice have a highly effective immune response following challenge with melanoma, bacterial infection, or Alzheimer disease. As shown in ACE 10/10 mice, enhanced monocytic function greatly contributes to the ability of the immune response to defend against a wide variety of antigenic and non-antigenic challenges.

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