Circulating versus Local Angiotensin II in Blood Pressure Control: Lessons from Tissue-Specific Expression of Angiotensin-Converting Enzyme (ACE)

2004 ◽  
Vol 14 (1-2) ◽  
pp. 137-146 ◽  
Author(s):  
Hong D. Xiao ◽  
Sebastien Fuchs ◽  
Kristen Frenzel ◽  
Lu Teng ◽  
Kenneth E. Bernstein
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Angiotensin Converting Enzyme ◽  
Blood Pressure Control ◽  
Pressure Control ◽  
Converting Enzyme ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

scholarly journals Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shunichiro Tsukamoto ◽  
Hiromichi Wakui ◽  
Kengo Azushima ◽  
Takahiro Yamaji ◽  
Shingo Urate ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Angiotensin Converting Enzyme ◽  
Functional Decline ◽  
Converting Enzyme ◽  
Specific Expression ◽  
Tissue Specific ◽  
Angiotensin Converting Enzyme 2 ◽  
Tissue Specific Expression

AbstractElevated angiotensin-converting enzyme 2 (ACE2) expression in organs that are potential targets of severe acute respiratory syndrome coronavirus 2 may increase the risk of coronavirus disease 2019 (COVID-19) infection. Previous reports show that ACE2 alter its tissue-specific expression patterns under various pathological conditions, including renal diseases. Here, we examined changes in pulmonary ACE2 expression in two mouse chronic kidney disease (CKD) models: adenine-induced (adenine mice) and aristolochic acid-induced (AA mice). We also investigated changes in pulmonary ACE2 expression due to renin–angiotensin system (RAS) blocker (olmesartan) treatment in these mice. Adenine mice showed significant renal functional decline and elevated blood pressure, compared with controls. AA mice also showed significant renal functional decline, compared with vehicles; blood pressure did not differ between groups. Renal ACE2 expression was significantly reduced in adenine mice and AA mice; pulmonary expression was unaffected. Olmesartan attenuated urinary albumin excretion in adenine mice, but did not affect renal or pulmonary ACE2 expression levels. The results suggest that the risk of COVID-19 infection may not be elevated in patients with CKD because of their stable pulmonary ACE2 expression. Moreover, RAS blockers can be used safely in treatment of COVID-19 patients with CKD.

Tissue Specific Expression of Angiotensin Converting Enzyme

1992 ◽  
pp. 376-383
Author(s):  
K. E. Bernstein ◽  
T. E. Howard ◽  
S-Y. Shai ◽  
K. G. Langford ◽  
R. Balogh
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

scholarly journals Tissue specific expression of angiotensin converting enzyme: A new way to study an old friend

2008 ◽  
Vol 8 (2) ◽  
pp. 171-176 ◽  
Author(s):  
Xiao Z. Shen ◽  
Hong D. Xiao ◽  
Ping Li ◽  
Chentao X. Lin ◽  
Sebastien Fuchs ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Converting Enzyme ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression
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