Podocyte Aging: Why and How Getting Old Matters

The effects of healthy aging on the kidney, and how these effects intersect with superimposed diseases, are highly relevant in the context of the population’s increasing longevity. Age-associated changes to podocytes, which are terminally differentiated glomerular epithelial cells, adversely affect kidney health. This review discusses the molecular and cellular mechanisms underlying podocyte aging, how these mechanisms might be augmented by disease in the aged kidney, and approaches to mitigate progressive damage to podocytes. Furthermore, we address how biologic pathways such as those associated with cellular growth confound aging in humans and rodents.

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Podocyte Aging: Why and How Getting Old Matters

Journal of the American Society of Nephrology ◽

10.1681/asn.2021-05-0614 ◽

2021 ◽

pp. ASN.2021-05-0614

Author(s):

Stuart Shankland ◽

Yuliang Wang ◽

Andrey Shaw ◽

Joshua Vaughan ◽

Jeffrey Pippin ◽

...

Keyword(s):

Epithelial Cells ◽

Healthy Aging ◽

Cellular Growth ◽

Progressive Damage ◽

Cellular Mechanisms ◽

Glomerular Epithelial Cells ◽

Aged Kidney ◽

Kidney Health

The effects of healthy aging on the kidney, and how these effects intersect with superimposed diseases, are highly relevant in the context of the population's increasing longevity. Age-associated changes to podocytes, which are terminally differentiated glomerular epithelial cells, adversely affect kidney health. This review discusses the molecular and cellular mechanisms underlying podocyte aging, how these mechanisms might be augmented by disease in the aged kidney, and approaches to mitigate progressive damage to podocytes. Furthermore, we address how biologic pathways such as those associated with cellular growth confound aging in humans and rodents.

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Faculty Opinions recommendation of Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718185639.793488054 ◽

2013 ◽

Author(s):

Hayo Castrop

Keyword(s):

Epithelial Cells ◽

Mouse Models ◽

Multiphoton Imaging ◽

Glomerular Epithelial Cells

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Changes in glomerular epithelial cells induced by FGF2 and FGF2 neutralizing antibody in puromycin aminonucleoside nephropathy

Kidney International ◽

10.1038/ki.1997.37 ◽

1997 ◽

Vol 51 (1) ◽

pp. 301-309 ◽

Cited By ~ 23

Author(s):

Tamaki Sasaki ◽

Yoshiyuki Jyo ◽

Nobuya Tanda ◽

Yasuhiko Kawakami ◽

Tsutomu Nohno ◽

...

Keyword(s):

Epithelial Cells ◽

Neutralizing Antibody ◽

Puromycin Aminonucleoside ◽

Glomerular Epithelial Cells

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Stromal cell and human prostatic epithelial cell in-vitro co-coltures: Growth and morphology

Urologia Journal ◽

10.1177/039156039606301s16 ◽

1996 ◽

Vol 63 (1_suppl) ◽

pp. 65-68

Author(s):

S. De Angeli ◽

A. Fandella ◽

C. Gatto ◽

S. Buoro ◽

C. Favretti ◽

...

Keyword(s):

Epithelial Cells ◽

Stromal Cells ◽

Marked Reduction ◽

Stromal Cell ◽

Optical Microscope ◽

Neutral Red ◽

Cellular Growth ◽

Murine Fibroblasts ◽

Prostatic Epithelial Cell

A study was carried out on the effect of stroma-epithelium interaction on cellular growth and morphology in co-coltures of U285 prostatic epithelial cells with human prostatic and esophageal stromal cells and with murine fibroblasts of the 3T3-J2 line. The proliferation rate was determined by growth tests of neutral red and kenacid blue. Morphological observations were made under optical microscope on the same cultures used for the growth tests. Results highlighted a marked reduction in cellular growth in the co-cultures compared to control cultures, as well as the tendency of the stromal and epithelial cells to re-organise themselves in pseudo-acinous structures.

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