Aberrant DNA methylation of the promoters of JAK2 and SOCS3 in juvenile systemic lupus erythematosus

2021 ◽  
Vol 32 (3) ◽  
pp. 48-54
Author(s):  
Mahsa Keshavarz-Fathi ◽  
Golshid Sanati ◽  
Maryam Sadr ◽  
Bahareh Mohebbi ◽  
Vahid Ziaee ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dna Methylation ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Juvenile Systemic Lupus Erythematosus ◽  
Aberrant Dna Methylation

DNA Methylation of CD70 Promoter in Juvenile Systemic Lupus Erythematosus

2020 ◽  
pp. 1-10
Author(s):  
Mahsa Keshavarz-Fathi ◽  
Golshid Sanati ◽  
Maryam Sadr ◽  
Bahareh Mohebbi ◽  
Vahid Ziaee ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dna Methylation ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Juvenile Systemic Lupus Erythematosus

scholarly journals Methyl donor micronutrients, CD40-ligand methylation and disease activity in systemic lupus erythematosus: A cross-sectional association study

Lupus ◽  
2021 ◽  
pp. 096120332110345
Author(s):  
Stefan Vordenbäumen ◽  
Alexander Sokolowski ◽  
Anna Rosenbaum ◽  
Claudia Gebhard ◽  
Johanna Raithel ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dna Methylation ◽  
T Cells ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Cd40 Ligand ◽  
Systemic Lupus ◽  
Methyl Donors ◽  
Methyl Donor ◽  
The Mean

Objective Hypomethylation of CD40-ligand (CD40L) in T-cells is associated with increased disease activity in systemic lupus erythematosus (SLE). We therefore investigated possible associations of dietary methyl donors and products with CD40L methylation status in SLE. Methods Food frequency questionnaires were employed to calculate methyl donor micronutrients in 61 female SLE patients (age 45.7 ± 12.0 years, disease duration 16.2 ± 8.4 years) and compared to methylation levels of previously identified key DNA methylation sites (CpG17 and CpG22) within CD40L promotor of T-cells using quantitative DNA methylation analysis on the EpiTYPER mass spectrometry platform. Disease activity was assessed by SLE Disease Activity Index (SLEDAI). Linear regression modelling was used. P values were adjusted according to Benjamini & Hochberg. Results Amongst the micronutrients assessed (g per day), methionine and cysteine were associated with methylation of CpG17 (β = 5.0 (95%CI: 0.6-9.4), p = 0.04; and β = 2.4 (0.6-4.1), p = 0.02, respectively). Methionine, choline, and cysteine were additionally associated with the mean methylation of the entire CD40L (β = 9.5 (1.0-18.0), p = 0.04; β = 1.6 (0.4-3.0), p = 0.04; and β = 4.3 (0.9-7.7), p = 0.02, respectively). Associations of the SLEDAI with hypomethylation were confirmed for CpG17 (β=-32.6 (-60.6 to -4.6), p = 0.04) and CpG22 (β=-38.3 (-61.2 to -15.4), p = 0.004), but not the mean methylation of CD40L. Dietary products with the highest impact on methylation included meat, ice cream, white bread, and cooked potatoes. Conclusions Dietary methyl donors may influence DNA methylation levels and thereby disease activity in SLE.

scholarly journals Epigenetic Contribution and Genomic Imprinting Dlk1-Dio3 miRNAs in Systemic Lupus Erythematosus

Genes ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 680
Author(s):  
Rujuan Dai ◽  
Zhuang Wang ◽  
S. Ansar Ahmed
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dna Methylation ◽  
Lupus Erythematosus ◽  
Critical Role ◽  
Methylation Status ◽  
Transcriptional Level ◽  
Dna Hypomethylation ◽  
Systemic Lupus ◽  
Multiple Organs ◽  
Genetic Imprinting

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease that afflicts multiple organs, especially kidneys and joints. In addition to genetic predisposition, it is now evident that DNA methylation and microRNAs (miRNAs), the two major epigenetic modifications, are critically involved in the pathogenesis of SLE. DNA methylation regulates promoter accessibility and gene expression at the transcriptional level by adding a methyl group to 5′ cytosine within a CpG dinucleotide. Extensive evidence now supports the importance of DNA hypomethylation in SLE etiology. miRNAs are small, non-protein coding RNAs that play a critical role in the regulation of genome expression. Various studies have identified the signature lupus-related miRNAs and their functional contribution to lupus incidence and progression. In this review, the mutual interaction between DNA methylation and miRNAs regulation in SLE is discussed. Some lupus-associated miRNAs regulate DNA methylation status by targeting the DNA methylation enzymes or methylation pathway-related proteins. On the other hand, DNA hyper- and hypo-methylation are linked with dysregulated miRNAs expression in lupus. Further, we specifically discuss the genetic imprinting Dlk1-Dio3 miRNAs that are subjected to DNA methylation regulation and are dysregulated in several autoimmune diseases, including SLE.

scholarly journals Association between academic performance and cognitive dysfunction in patients with juvenile systemic lupus erythematosus

2016 ◽  
Vol 56 (3) ◽  
pp. 252-257
Author(s):  
Renan Bazuco Frittoli ◽  
Karina de Oliveira Peliçari ◽  
Bruna Siqueira Bellini ◽  
Roberto Marini ◽  
Paula Teixeira Fernandes ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Academic Performance ◽  
Cognitive Dysfunction ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Juvenile Systemic Lupus Erythematosus

Juvenile systemic lupus erythematosus and dermatomyositis associated with urticarial vasculitis syndrome: a unique presentation

2010 ◽  
Vol 32 (11) ◽  
pp. 3643-3646 ◽  
Author(s):  
Patrícia A. Macêdo ◽  
Carolina B. Garcia ◽  
Monique K. Schmitz ◽  
Levi H. Jales ◽  
Rosa M. R. Pereira ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Urticarial Vasculitis ◽  
Juvenile Systemic Lupus Erythematosus

Poor agreement of objectively measured and self-reported physical activity in juvenile dermatomyositis and juvenile systemic lupus erythematosus

2016 ◽  
Vol 35 (6) ◽  
pp. 1507-1514 ◽  
Author(s):  
Ana Jéssica Pinto ◽  
Hamilton Roschel ◽  
Fabiana Braga Benatti ◽  
Ana Lúcia de Sá Pinto ◽  
Adriana Maluf Elias Sallum ◽  
...  
Keyword(s):  
Physical Activity ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Juvenile Dermatomyositis ◽  
Poor Agreement ◽  
Systemic Lupus ◽  
Juvenile Systemic Lupus Erythematosus ◽  
Objectively Measured

Global DNA methylation, DNMT1, and MBD2 in patients with systemic lupus erythematosus

Lupus ◽  
2010 ◽  
Vol 20 (2) ◽  
pp. 131-136 ◽  
Author(s):  
CC Liu ◽  
TT Ou ◽  
CC Wu ◽  
RN Li ◽  
YC Lin ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Dna Methylation ◽  
Lupus Erythematosus ◽  
Global Dna Methylation ◽  
Systemic Lupus
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