Utilizing objective measures of acute and chronic mechanical insult to determine their contributions to post-traumatic osteoarthritis risk

2019 ◽  
Author(s):  
Kevin Nathaniel Dibbern
2013 ◽  
Vol 22 (6) ◽  
pp. 679-687 ◽  
Author(s):  
Anne Richards ◽  
Thomas J. Metzler ◽  
Leslie M. Ruoff ◽  
Sabra S. Inslicht ◽  
Madhu Rao ◽  
...  

1998 ◽  
Vol 120 (6) ◽  
pp. 704-709 ◽  
Author(s):  
W. N. Newberry ◽  
J. J. Garcia ◽  
C. D. Mackenzie ◽  
C. E. Decamp ◽  
R. C. Haut

Chronic degeneration of articular cartilage and bone in a rabbit model of post-traumatic osteoarthrosis has been hypothesized to occur due to acute stresses that exceed a threshold for injury. In this study, we impacted the rabbit patellofemoral joint at low and high intensities. High-intensity impacts produced degenerative changes in the joint, such as softening of retropatellar cartilage, as measured by indentation, an increase in histopathology of the cartilage, and an increase in thickness of sub-chondral bone underlying the cartilage. Low-intensity impacts did not cause these progressive changes. These data suggest that low-intensity impacts produced acute tissue stresses below the injury threshold, while high-intensity impacts produced stresses that exceeded the threshold for disease pathogenesis. This study begins to identify “safe” and “unsafe” ranges of acute tissue stress, using the rabbit patella, which may have future utility in the design of injury prevention devices for the human.


1997 ◽  
Vol 40 (4) ◽  
pp. 900-911 ◽  
Author(s):  
Marilyn E. Demorest ◽  
Lynne E. Bernstein

Ninety-six participants with normal hearing and 63 with severe-to-profound hearing impairment viewed 100 CID Sentences (Davis & Silverman, 1970) and 100 B-E Sentences (Bernstein & Eberhardt, 1986b). Objective measures included words correct, phonemes correct, and visual-phonetic distance between the stimulus and response. Subjective ratings were made on a 7-point confidence scale. Magnitude of validity coefficients ranged from .34 to .76 across materials, measures, and groups. Participants with hearing impairment had higher levels of objective performance, higher subjective ratings, and higher validity coefficients, although there were large individual differences. Regression analyses revealed that subjective ratings are predictable from stimulus length, response length, and objective performance. The ability of speechreaders to make valid performance evaluations was interpreted in terms of contemporary word recognition models.


1991 ◽  
Vol 36 (7) ◽  
pp. 641-641
Author(s):  
No authorship indicated

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