scholarly journals Dental Treatment for Adult Atopic Dermatitis after Long Time Steroid Therapy

1997 ◽  
Vol 42 (7) ◽  
pp. 168-172
Keyword(s):  
Atopic Dermatitis ◽  
Steroid Therapy ◽  
Dental Treatment ◽  
Long Time

scholarly journals A novel hydrocortisone-ethanol gel ointment for treating atopic dermatitis (eczema) in children: A double blind, randomized, controlled clinical trial

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Dale Lawrence Pearlman
Keyword(s):  
Clinical Trial ◽  
Atopic Dermatitis ◽  
Controlled Study ◽  
Controlled Clinical Trial ◽  
Severe Atopic Dermatitis ◽  
Double Blind ◽  
Parental Concerns ◽  
Score Improvement ◽  
Long Time ◽  
Secondary Endpoints

Importance: Current treatments for moderate to severe atopic dermatitis (AD) in children are limited by incomplete efficacy, long time to benefit, and parental concerns about safety. This study evaluated a novel ointment for treating AD containing 0.83% hydrocortisone and 17% dispersed ethanol gel micro bubbles.  Observations:20 children with moderate to severe AD participated in a one-week double blind, randomized, and controlled clinical trial. They were randomly assigned to apply BID either an ointment with 1% hydrocortisone ointment (HC) or a novel ointment containing 1% hydrocortisone and dispersed ethanol gel droplets (HC-EG).   The primary endpoint was superiority of HC-EG over HC ointment in SCORAD score improvement during therapy. A secondary endpoint was improvement in pruritus score during therapy. Both the primary and secondary endpoints were reached in this study. SCORAD score improved 74% on average with HC-EG ointment vs 41% with HC ointment (p=.02). Pruritus score improved 68% on average with HC-EG ointment vs 37% with HC ointment (p=.009). No toxicity requiring stopping therapy was observed in either treatment group.  Conclusions and Relevance: Inthis small controlled study HC-EG ointment was superior to HC ointment both in improving visible rash and pruritus of AD. Parents felt HC-EG ointment was safe because it contains no prescription corticosteroids, prescription immunosuppressants, or antibiotics. Independent larger studies would be a next step in evaluating further this new way to treat AD. 

scholarly journals Topical steroid therapy in atopic dermatitis in theory and practice

2015 ◽  
Vol 3 ◽  
pp. 162-166 ◽  
Author(s):  
Renata Jeziorkowska ◽  
Anna Sysa-Jędrzejowska ◽  
Zbigniew Samochocki
Keyword(s):  
Atopic Dermatitis ◽  
Steroid Therapy ◽  
Topical Steroid ◽  
Theory And Practice ◽  
Topical Steroid Therapy

scholarly journals Strategies for Selecting Therapeutic Tactics for Reducing Transcutaneous Sensibilisation Risk in Infants with Atopic Dermatitis: Cohort Retrospective Prospective Study

2021 ◽  
Vol 18 (1) ◽  
pp. 8-16
Author(s):  
Dmitri V. Fedorov ◽  
Nikolay N. Murashkin ◽  
Svetlana G. Makarova ◽  
Roman A. Ivanov
Keyword(s):  
Atopic Dermatitis ◽  
Maintenance Therapy ◽  
Allergic Diseases ◽  
Study Groups ◽  
Specific Ige ◽  
Barrier Dysfunction ◽  
Long Time ◽  
Group 2 ◽  
Key Aspects ◽  
Group 1

Background. One of the key aspects in the development of atopic dermatitis (AtD) is epidermal barrier dysfunction leading to the penetration of pathogens and allergens through the skin with further body sensibilisation to them. Such pathological interaction can later on lead to the development of various allergic diseases in the child which not only worsen the course of atopic dermatitis itself, but also significantly reduce the quality of life of these patients. Objective. Aim of the study is to estimate the efficacy of therapeutic approaches for treatment of atopic dermatitis in reducing the transcutaneous sensibilisation risk in infants. Methods. The study included children aged 1 to 4 months with established AtD from moderate to severe forms. The severity of AtD was estimated via the EASI index. The level of specific IgE (sIgE) to food and domestic allergens was measured by the ImmunoCAP method using special reagents’ sets. The sensibilisation class was established depending on the sIgE index. Statistical analysis of the studied indexes shift and their comparison between the study groups was performed via multivariate analysis of variance (ANOVA). Results. The study included 81 patients. All patients were divided into two groups after basic AtD therapy with topical glucocorticosteroids (tGCS). Patients from study group № 1 received maintenance therapy with topical calcineurin inhibitor (TCI) (pimecrolimus 1%; PIM) for a long time, while patients from group № 2 continued to apply tGCS as proactive therapy. We have revealed that the level of sensibilisation to chicken protein and to the mixture of domestic allergens “domestic dust” was lower to the 12th month of life in group № 1 compared to group № 2 as a result of the data analysis. Children in group № 1 had faster and more significant decrease in the severity of AtD in comparison to group № 2 according to EASI index. Conclusion. Maintenance therapy including PIM is more efficient in reducing AtD severity and in prevention of transcutaneous sensibilisation in infants.

scholarly journals Severe аtopic dermatitis: problems in care

2012 ◽  
Vol 9 (4) ◽  
pp. 33-38
Author(s):  
E S Fedenko ◽  
O G Elisyutina ◽  
O V Shtyrbul
Keyword(s):  
Atopic Dermatitis ◽  
Topical Therapy ◽  
Calcineurin Inhibitors ◽  
Intravenous Immunoglobulins ◽  
Difficult Problem ◽  
Severe Atopic Dermatitis ◽  
Complex Treatment ◽  
Topical Calcineurin Inhibitors ◽  
Long Time ◽  
And Control

In this article problems in care of severe atopic dermatitis (AD) are considered. The main medications for AD treatment are topical corticosteroids, topical calcineurin inhibitors and emollients. In spite of adequate topical therapy the disease often gets a severe recurrent course with frequent exacerbations. In such cases treatment is considered to be a difficult problem and quite often it is necessary to use systemic preparations: corticosteroids, immunosupressors, cytostatics. They are able to reduce and control exacerbations fast and effectively, but because of side effects these preparations shouldn’t be applied for a long time. Considering increase of severe AD cases, now great attention is given to immunotherapy. In the article the retrospective analysis of data about 56 severe AD patients who underwent a course of complex treatment including plasmapheresis and intravenous immunoglobulins is presented.

scholarly journals Estimation of proinflammatory cytokine and heat shock protein levels in atopic dermatitis

2019 ◽  
Vol 36 (3) ◽  
pp. 38-42
Author(s):  
Natalia M. Ivanova ◽  
Irina V. Kibalina ◽  
Namzil N. Tsybikov
Keyword(s):  
Atopic Dermatitis ◽  
Stress State ◽  
Proinflammatory Cytokine ◽  
Statistical Processing ◽  
Hsp 70 ◽  
Hsp70 Level ◽  
Clinical Symptomatology ◽  
Protein Levels ◽  
Inflammatory Damage ◽  
Long Time

Aim. To estimate the proinflammatory cytokineI L-17α level, HSP-70 level and autoantibodies to it in pathogenesis of atopic dermatitis (AD) at its exacerbation stage. Materials and methods. Twenty patients aged 18–35 years were examined; cytokine IL-17α levels, HSP-70 chaperone levels and autoantibodies to it were studied in patients, suffering from typical form of atopic dermatitis at exacerbation stage. Statistical processing of the obtained material was implemented with STATISTICA 6.1 for Windows. Results. Atopic dermatitis causes chronic inflammatory damage of the skin, the cells are in stress state for a long time that contributes to accumulation of the damaged proteins in them and significant growth of chaperone synthesis. Conclusions. In the period of active clinical symptomatology, patients with atopic dermatitis demonstrated decrease in blood IL-17α concentration and increase in HSP70 level and autoantibodies to it.

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