scholarly journals Various Medical Aspects of Liver Transplantation and its Survival Prediction using Machine Learning Techniques

2017 ◽  
Vol 10 (13) ◽  
pp. 1-17 ◽  
Author(s):  
C. G. Raji ◽  
S. S. Vinod Chandra ◽  
◽  
Keyword(s):  
Machine Learning ◽  
Liver Transplantation ◽  
Machine Learning Techniques ◽  
Survival Prediction ◽  
Learning Techniques

scholarly journals Survival prediction models since liver transplantation - comparisons between Cox models and machine learning techniques

2020 ◽  
Author(s):  
Georgios Kantidakis ◽  
Hein Putter ◽  
Carlo Lancia ◽  
Jacob de Boer ◽  
Andries E Braat ◽  
...  
Keyword(s):  
Machine Learning ◽  
Neural Networks ◽  
Liver Transplantation ◽  
Prediction Models ◽  
Machine Learning Techniques ◽  
Brier Score ◽  
Survival Prediction ◽  
Cox Models ◽  
Learning Techniques ◽  
Random Survival Forest

Abstract Background: Predicting survival of recipients after liver transplantation is regarded as one of the most important challenges in contemporary medicine. Hence, improving on current prediction models is of great interest.Nowadays, there is a strong discussion in the medical field about machine learning (ML) and whether it has greater potential than traditional regression models when dealing with complex data. Criticism to ML is related to unsuitable performance measures and lack of interpretability which is important for clinicians.Methods: In this paper, ML techniques such as random forests and neural networks are applied to large data of 62294 patients from the United States with 97 predictors selected on clinical/statistical grounds, over more than 600, to predict survival from transplantation. Of particular interest is also the identification of potential risk factors. A comparison is performed between 3 different Cox models (with all variables, backward selection and LASSO) and 3 machine learning techniques: a random survival forest and 2 partial logistic artificial neural networks (PLANNs). For PLANNs, novel extensions to their original specification are tested. Emphasis is given on the advantages and pitfalls of each method and on the interpretability of the ML techniques.Results: Well-established predictive measures are employed from the survival field (C-index, Brier score and Integrated Brier Score) and the strongest prognostic factors are identified for each model. Clinical endpoint is overall graft-survival defined as the time between transplantation and the date of graft-failure or death. The random survival forest shows slightly better predictive performance than Cox models based on the C-index. Neural networks show better performance than both Cox models and random survival forest based on the Integrated Brier Score at 10 years.Conclusion: In this work, it is shown that machine learning techniques can be a useful tool for both prediction and interpretation in the survival context. From the ML techniques examined here, PLANN with 1 hidden layer predicts survival probabilities the most accurately, being as calibrated as the Cox model with all variables.

scholarly journals Survival prediction models since liver transplantation - comparisons between Cox models and machine learning techniques

2020 ◽  
Author(s):  
Georgios Kantidakis ◽  
Hein Putter ◽  
Carlo Lancia ◽  
Jacob de Boer ◽  
Andries E Braat ◽  
...  
Keyword(s):  
Machine Learning ◽  
Neural Networks ◽  
Liver Transplantation ◽  
Prediction Models ◽  
Machine Learning Techniques ◽  
Brier Score ◽  
Survival Prediction ◽  
Cox Models ◽  
Learning Techniques ◽  
Random Survival Forest

Abstract Background: Predicting survival of recipients after liver transplantation is regarded as one of the most important challenges in contemporary medicine. Hence, improving on current prediction models is of great interest. Nowadays, there is a strong discussion in the medical field about machine learning (ML) and whether it has greater potential than traditional regression models when dealing with complex data. Criticism to ML is related to unsuitable performance measures and lack of interpretability which is important for clinicians. Methods: In this paper, ML techniques such as random forests and neural networks are applied to large data of 62294 patients from the United States with 97 predictors selected on clinical/statistical grounds, over more than 600, to predict survival from transplantation. Of particular interest is also the identification of potential risk factors. A comparison is performed between 3 different Cox models (with all variables, backward selection and LASSO) and 3 machine learning techniques: a random survival forest and 2 partial logistic artificial neural networks (PLANNs). For PLANNs, novel extensions to their original specification are tested. Emphasis is given on the advantages and pitfalls of each method and on the interpretability of the ML techniques. Results: Well-established predictive measures are employed from the survival field (C-index, Brier score and Integrated Brier Score) and the strongest prognostic factors are identified for each model. Clinical endpoint is overall graft-survival defined as the time between transplantation and the date of graft-failure or death. The random survival forest shows slightly better predictive performance than Cox models based on the C-index. Neural networks show better performance than both Cox models and random survival forest based on the Integrated Brier Score at 10 years. Conclusion: In this work, it is shown that machine learning techniques can be a useful tool for both prediction and interpretation in the survival context. From the ML techniques examined here, PLANN with 1 hidden layer predicts survival probabilities the most accurately, being as calibrated as the Cox model with all variables.

scholarly journals Survival prediction models since liver transplantation - comparisons between Cox models and machine learning techniques

2020 ◽  
Author(s):  
Georgios Kantidakis ◽  
Hein Putter ◽  
Carlo Lancia ◽  
Jacob de Boer ◽  
Andries E Braat ◽  
...  
Keyword(s):  
Machine Learning ◽  
Neural Networks ◽  
Liver Transplantation ◽  
Prediction Models ◽  
Machine Learning Techniques ◽  
Brier Score ◽  
Survival Prediction ◽  
Cox Models ◽  
Learning Techniques ◽  
Random Survival Forest

Abstract Background: Predicting survival of recipients after liver transplantation is regarded as one of the most important challenges in contemporary medicine. Hence, improving on current prediction models is of great interest. Nowadays, there is a strong discussion in the medical field about machine learning (ML) and whether it has greater potential than traditional regression models when dealing with complex data. Criticism to ML is related to unsuitable performance measures and lack of interpretability which is important for clinicians. Methods: In this paper, ML techniques such as random forests and neural networks are applied to large data of 62294 patients from the United States with 97 predictors selected on clinical/statistical grounds, over more than 600, to predict survival from transplantation. Of particular interest is also the identification of potential risk factors. A comparison is performed between 3 different Cox models (with all variables, backward selection and LASSO) and 3 machine learning techniques: a random survival forest and 2 partial logistic artificial neural networks (PLANNs). For PLANNs, novel extensions to their original specification are tested. Emphasis is given on the advantages and pitfalls of each method and on the interpretability of the ML techniques. Results: Well-established predictive measures are employed from the survival field (C-index, Brier score and Integrated Brier Score) and the strongest prognostic factors are identified for each model. Clinical endpoint is overall graft-survival defined as the time between transplantation and the date of graft-failure or death. The random survival forest shows slightly better predictive performance than Cox models based on the C-index. Neural networks show better performance than both Cox models and random survival forest based on the Integrated Brier Score at 10 years. Conclusion: In this work, it is shown that machine learning techniques can be a useful tool for both prediction and interpretation in the survival context. From the ML techniques examined here, PLANN with 1 hidden layer predicts survival probabilities the most accurately, being as calibrated as the Cox model with all variables.

scholarly journals Survival prediction models since liver transplantation - comparisons between Cox models and machine learning techniques

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Georgios Kantidakis ◽  
Hein Putter ◽  
Carlo Lancia ◽  
Jacob de Boer ◽  
Andries E. Braat ◽  
...  
Keyword(s):  
Machine Learning ◽  
Risk Factors ◽  
Neural Networks ◽  
Liver Transplantation ◽  
Prediction Models ◽  
Machine Learning Techniques ◽  
Brier Score ◽  
Cox Models ◽  
Learning Techniques ◽  
Random Survival Forest

Abstract Background Predicting survival of recipients after liver transplantation is regarded as one of the most important challenges in contemporary medicine. Hence, improving on current prediction models is of great interest.Nowadays, there is a strong discussion in the medical field about machine learning (ML) and whether it has greater potential than traditional regression models when dealing with complex data. Criticism to ML is related to unsuitable performance measures and lack of interpretability which is important for clinicians. Methods In this paper, ML techniques such as random forests and neural networks are applied to large data of 62294 patients from the United States with 97 predictors selected on clinical/statistical grounds, over more than 600, to predict survival from transplantation. Of particular interest is also the identification of potential risk factors. A comparison is performed between 3 different Cox models (with all variables, backward selection and LASSO) and 3 machine learning techniques: a random survival forest and 2 partial logistic artificial neural networks (PLANNs). For PLANNs, novel extensions to their original specification are tested. Emphasis is given on the advantages and pitfalls of each method and on the interpretability of the ML techniques. Results Well-established predictive measures are employed from the survival field (C-index, Brier score and Integrated Brier Score) and the strongest prognostic factors are identified for each model. Clinical endpoint is overall graft-survival defined as the time between transplantation and the date of graft-failure or death. The random survival forest shows slightly better predictive performance than Cox models based on the C-index. Neural networks show better performance than both Cox models and random survival forest based on the Integrated Brier Score at 10 years. Conclusion In this work, it is shown that machine learning techniques can be a useful tool for both prediction and interpretation in the survival context. From the ML techniques examined here, PLANN with 1 hidden layer predicts survival probabilities the most accurately, being as calibrated as the Cox model with all variables. Trial registration Retrospective data were provided by the Scientific Registry of Transplant Recipients under Data Use Agreement number 9477 for analysis of risk factors after liver transplantation.

scholarly journals Can Machine-learning Techniques Be Used for 5-year Survival Prediction of Patients With Chondrosarcoma?

2018 ◽  
Vol 476 (10) ◽  
pp. 2040-2048 ◽  
Author(s):  
Quirina C. B. S. Thio ◽  
Aditya V. Karhade ◽  
Paul T. Ogink ◽  
Kevin A. Raskin ◽  
Karen De Amorim Bernstein ◽  
...  
Keyword(s):  
Machine Learning ◽  
Machine Learning Techniques ◽  
Survival Prediction ◽  
Learning Techniques

scholarly journals A comparison of machine learning techniques for survival prediction in breast cancer

2011 ◽  
Vol 4 (1) ◽  
Author(s):  
Leonardo Vanneschi ◽  
Antonella Farinaccio ◽  
Giancarlo Mauri ◽  
Marco Antoniotti ◽  
Paolo Provero ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Machine Learning ◽  
Machine Learning Techniques ◽  
Survival Prediction ◽  
Learning Techniques

scholarly journals Statistical methods versus machine learning techniques for donor-recipient matching in liver transplantation

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0252068
Author(s):  
David Guijo-Rubio ◽  
Javier Briceño ◽  
Pedro Antonio Gutiérrez ◽  
Maria Dolores Ayllón ◽  
Rubén Ciria ◽  
...  
Keyword(s):  
Machine Learning ◽  
Liver Transplantation ◽  
Statistical Methods ◽  
Machine Learning Techniques ◽  
Gradient Boosting ◽  
Support Vector ◽  
End Points ◽  
Liver Allocation ◽  
Learning Techniques ◽  
Modelling Techniques

Donor-Recipient (D-R) matching is one of the main challenges to be fulfilled nowadays. Due to the increasing number of recipients and the small amount of donors in liver transplantation, the allocation method is crucial. In this paper, to establish a fair comparison, the United Network for Organ Sharing database was used with 4 different end-points (3 months, and 1, 2 and 5 years), with a total of 39, 189 D-R pairs and 28 donor and recipient variables. Modelling techniques were divided into two groups: 1) classical statistical methods, including Logistic Regression (LR) and Naïve Bayes (NB), and 2) standard machine learning techniques, including Multilayer Perceptron (MLP), Random Forest (RF), Gradient Boosting (GB) or Support Vector Machines (SVM), among others. The methods were compared with standard scores, MELD, SOFT and BAR. For the 5-years end-point, LR (AUC = 0.654) outperformed several machine learning techniques, such as MLP (AUC = 0.599), GB (AUC = 0.600), SVM (AUC = 0.624) or RF (AUC = 0.644), among others. Moreover, LR also outperformed standard scores. The same pattern was reproduced for the others 3 end-points. Complex machine learning methods were not able to improve the performance of liver allocation, probably due to the implicit limitations associated to the collection process of the database.

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