Epidemiology and diagnosis of cervical cancer

A. F. Ourmantcheeva; V. M . Merabishvili; S. A. Selcov; V. I. Novik; N. R. Safronnikova; G. F. Kutusheva; A. E. Vorontsova; A. S. Lisyanskaya; G. N. Vedeneeva; V. A. Golovanova; F. R. Kutueva; D. R. Zeldovich; G. M. Manikhas; E. K. Ailamazyan

doi:10.17816/jowd89302

Epidemiology and diagnosis of cervical cancer

Journal of obstetrics and women s diseases ◽

10.17816/jowd89302 ◽

2021 ◽

Vol 50 (1) ◽

pp. 80-86

Author(s):

A. F. Ourmantcheeva ◽

V. M . Merabishvili ◽

S. A. Selcov ◽

V. I. Novik ◽

N. R. Safronnikova ◽

...

Keyword(s):

Cervical Cancer ◽

Invasive Cervical Cancer ◽

Early Diagnostics ◽

Saint Petersburg

The data of populational and hospital cancer registers, cytological and immunological laboratories of Saint-Petersburg are examined. More than 350 new invasive cervical cancer cases are registered annually. Since 1970 up to 1991 oncological morbidity decreased from 14,7 to 8,1 per 100000 women, but then we witness steady rise of standardized indeces up to 9,9 in 1999. Increasingrate of so called neglectedforms of cervical cancer (III-IV stages), especially amongyoung women, is a disturbing fact. The issues of prophylaxis and early diagnostics of cervical cancer are discussed in the article. The results of cytological and virological examination of women of different contingents are drawn.

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Frequent high-risk HPV co-infections excluding types 16 or 18 in cervical neoplasia in Guadeloupe

BMC Cancer ◽

10.1186/s12885-021-07940-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Stanie Gaete ◽

Aviane Auguste ◽

Bernard Bhakkan ◽

Jessica Peruvien ◽

Cecile Herrmann-Storck ◽

...

Keyword(s):

Cervical Cancer ◽

Invasive Cervical Cancer ◽

Population Based ◽

Multiple Infections ◽

French Caribbean ◽

Papilloma Virus ◽

Hpv Genotyping ◽

Hpv Status ◽

Hpv Genotypes ◽

High Risk Hpv

Abstract Background Cervical cancer is the fourth cancer worldwide. The Human Papilloma Virus is responsible for 99% of the cases but the distribution of its genotypes varies among populations. We aimed to identify HPV genotypes distribution in women with grade 2/3 cervical intraepithelial dysplasia or invasive cervical cancer in Guadeloupe, a French Caribbean territory with a population mainly of African descent. Methods We used paraffin-embedded tumors for viral DNA extraction from women diagnosed between 2014 and 2016 and identified by the population-based cancer registry. The HPV Genotyping was performed with the InnoLIPA HPV Genotyping Extra kit®. Results Overall, 213 samples out of the 321 eligible records were analyzed. The HPV status was positive for 94% of the cases. The five most common oncogenic HPV genotypes were HPV31 (47%), HPV33 (38%), HPV16 (32%), HPV44 (31%) and HPV26 (28%). HPV18 was found in only in 5% of the cases. Among the studied cases, 94% had multiple infections. More than 60% of single infections were HPV16-related, accounting for 35% of HPV16 infections. Conclusions These results show a different distribution of oncogenic HPVs in Guadeloupe with “31 > 33 > 16” and a high frequency of multiple infections. Despite a lower coverage, the nine-valent vaccine is nevertheless adequate.

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