Thermoregulation in puberty in healthy people and patients with pathology of the autonomic nervous system

Melanin-concentrating hormone (MCH) plays an important role in energy balance. The current studies were carried out on a new line of mice lacking the rodent MCH receptor (MCHR1−/− mice). These mice confirmed the previously reported lean phenotype characterized by increased energy expenditure and modestly increased caloric intake. Because MCH is expressed in the lateral hypothalamic area, which also has an important role in the regulation of the autonomic nervous system, heart rate and blood pressure were measured by a telemetric method to investigate whether the increased energy expenditure in these mice might be due to altered autonomic nervous system activity. Male MCHR1−/− mice demonstrated a significantly increased heart rate [24-h period: wild type 495 ± 4 vs. MCHR1−/− 561 ± 8 beats/min ( P < 0.001); dark phase: wild type 506 ± 8 vs. MCHR1−/− 582 ± 9 beats/min ( P < 0.001); light phase: wild type 484 ± 13 vs. MCHR1−/− 539 ± 9 beats/min ( P < 0.005)] with no significant difference in mean arterial pressure [wild type 110 ± 0.3 vs. MCHR1−/− 113 ± 0.4 mmHg ( P > 0.05)]. Locomotor activity and core body temperature were higher in the MCHR1−/− mice during the dark phase only and thus temporally dissociated from heart rate differences. On fasting, wild-type animals rapidly downregulated body temperature and heart rate. MCHR1−/− mice displayed a distinct delay in the onset of this downregulation. To investigate the mechanism underlying these differences, autonomic blockade experiments were carried out. Administration of the adrenergic antagonist metoprolol completely reversed the tachycardia seen in MCHR1−/− mice, suggesting an increased sympathetic tone.

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Warming of insufflation gas during laparoscopic hysterectomy: effect on body temperature and the autonomic nervous system

Acta Anaesthesiologica Scandinavica ◽

10.1034/j.1399-6576.1999.431002.x ◽

1999 ◽

Vol 43 (10) ◽

pp. 974-978 ◽

Cited By ~ 20

Author(s):

K. Nelskylä ◽

A. Yli-Hankala ◽

J. Sjöberg ◽

I. Korhonen ◽

K. Korttila

Keyword(s):

Nervous System ◽

Autonomic Nervous System ◽

Body Temperature ◽

Laparoscopic Hysterectomy ◽

Autonomic Nervous

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Principles of Neuroendocrinology and Hypothalamic Function

10.1093/med/9780197512166.003.0015 ◽

2021 ◽

pp. 127-132

Author(s):

Elizabeth A. Coon ◽

Eduardo E. Benarroch

Keyword(s):

Nervous System ◽

Sexual Behavior ◽

Autonomic Nervous System ◽

Temperature Regulation ◽

Emotional Responses ◽

Endocrine System ◽

Pituitary Hormones ◽

Diurnal Rhythms ◽

Autonomic Nervous ◽

Hypothalamic Function

The hypothalamus is the neural center of the endocrine system, the regulator of the autonomic nervous system, and the circadian and seasonal clock for behavioral and sleep-wake functions. The hypothalamus maintains homeostasis by integrating cortical, limbic, and spinal inputs and by affecting hormone release, temperature regulation, intake of food and water, sexual behavior and reproduction, emotional responses, and diurnal rhythms. As the link from the nervous system to the endocrine system, the hypothalamus synthesizes and secretes neurohormones that stimulate or inhibit the secretion of pituitary hormones.

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