Warming of insufflation gas during laparoscopic hysterectomy: effect on body temperature and the autonomic nervous system

The objective: was to evaluate the effectiveness of various anesthesia options for laparoscopic hysterectomy, including low-opioid (LOA) and opioid-free anesthesia (OFA) by studying the dynamics of heart rate variability (HRV) indicators.Materials and methods. 102 patients were randomly assigned to 3 groups: 37 patients who received standard opioid anesthesia (control group), 33 women who received the LOA group, and 32 patients who received OFA.Results. Laparoscopic hysterectomy is accompanied by tension of the autonomic nervous system, especially its sympathetic link, which is manifested by an increase in the index of vago-sympathetic interaction at the traumatic stage of the operation. These changes were most significant in patients who received standard and opioid-free anesthesia, which indirectly indicates insufficient stress protection of these types of intraoperative anesthesia.Conclusions. The use of low-opioid anesthesia is accompanied by a greater stabilization of HRV indices, which indicates its sufficient autonomic protection during laparoscopic hysterectomy than standard and opioid-free anesthesia.

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The effect of repetitive mild hyperthermia on body temperature, the autonomic nervous system, and innate and adaptive immunity

Biomedical Research ◽

10.2220/biomedres.36.135 ◽

2015 ◽

Vol 36 (2) ◽

pp. 135-142 ◽

Cited By ~ 9

Author(s):

Chikako TOMIYAMA ◽

Mayumi WATANABE ◽

Takashi HONMA ◽

Akihiro INADA ◽

Takayoshi HAYAKAWA ◽

...

Keyword(s):

Nervous System ◽

Autonomic Nervous System ◽

Body Temperature ◽

Mild Hyperthermia ◽

Autonomic Nervous

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Mice lacking melanin-concentrating hormone receptor 1 demonstrate increased heart rate associated with altered autonomic activity

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.00134.2004 ◽

2004 ◽

Vol 287 (4) ◽

pp. R749-R758 ◽

Cited By ~ 64

Author(s):

Annika Åstrand ◽

Mohammad Bohlooly-Y ◽

Sara Larsdotter ◽

Margit Mahlapuu ◽

Harriet Andersén ◽

...

Keyword(s):

Heart Rate ◽

Nervous System ◽

Autonomic Nervous System ◽

Body Temperature ◽

Energy Expenditure ◽

Dark Phase ◽

Wild Type ◽

Autonomic Nervous ◽

Significant Difference ◽

Melanin Concentrating Hormone

Melanin-concentrating hormone (MCH) plays an important role in energy balance. The current studies were carried out on a new line of mice lacking the rodent MCH receptor (MCHR1−/− mice). These mice confirmed the previously reported lean phenotype characterized by increased energy expenditure and modestly increased caloric intake. Because MCH is expressed in the lateral hypothalamic area, which also has an important role in the regulation of the autonomic nervous system, heart rate and blood pressure were measured by a telemetric method to investigate whether the increased energy expenditure in these mice might be due to altered autonomic nervous system activity. Male MCHR1−/− mice demonstrated a significantly increased heart rate [24-h period: wild type 495 ± 4 vs. MCHR1−/− 561 ± 8 beats/min ( P < 0.001); dark phase: wild type 506 ± 8 vs. MCHR1−/− 582 ± 9 beats/min ( P < 0.001); light phase: wild type 484 ± 13 vs. MCHR1−/− 539 ± 9 beats/min ( P < 0.005)] with no significant difference in mean arterial pressure [wild type 110 ± 0.3 vs. MCHR1−/− 113 ± 0.4 mmHg ( P > 0.05)]. Locomotor activity and core body temperature were higher in the MCHR1−/− mice during the dark phase only and thus temporally dissociated from heart rate differences. On fasting, wild-type animals rapidly downregulated body temperature and heart rate. MCHR1−/− mice displayed a distinct delay in the onset of this downregulation. To investigate the mechanism underlying these differences, autonomic blockade experiments were carried out. Administration of the adrenergic antagonist metoprolol completely reversed the tachycardia seen in MCHR1−/− mice, suggesting an increased sympathetic tone.

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