scholarly journals Auditory pathways

2020 ◽  
Vol VI (3) ◽  
pp. 162-203
Author(s):  
V. E. Larionov

Until the eighties of the present century, anatomists and neuropathologists developed the question of the endings of the auditory nerves in the medulla oblongata, expressing at the same time many different assumptions about the origins of them in various places of this brain, for them a different number of roots and ascribing to them all possible directions.

2011 ◽  
Vol 114 (2) ◽  
pp. 414-425 ◽  
Author(s):  
Tetsuji Sekiya ◽  
Masahiro Matsumoto ◽  
Ken Kojima ◽  
Kazuya Ono ◽  
Yayoi S. Kikkawa ◽  
...  

Object Hearing levels following microsurgical treatment gradually deteriorate in a number of patients treated for vestibular schwannoma (VS), especially in the subacute postoperative stage. The cause of this late-onset deterioration of hearing is not completely understood. The aim of this study was to investigate the possibility that reactive gliosis is a contributory factor. Methods Mechanical damage to nerve tissue is a feature of complex surgical procedures. To explore this aspect of VS treatment, the authors compressed rat auditory nerves with 2 different degrees of injury while monitoring the compound action potentials of the auditory nerve and the auditory brainstem responses. In this experimental model, the axons of the auditory nerve were quantitatively and highly selectively damaged in the cerebellopontine angle without permanent compromise of the blood supply to the cochlea. The temporal bones were processed for immunohistochemical analysis at 1 week and at 8 weeks after compression. Results Reactive gliosis was induced not only in the auditory nerve but also in the cochlear nucleus following mechanical trauma in which the general shape of the auditory brainstem response was maintained. There was a substantial outgrowth of astrocytic processes from the transitional zone into the peripheral portion of the auditory nerve, leading to an invasion of dense gliotic tissue in the auditory nerve. The elongated astrocytic processes ran in parallel with the residual auditory neurons and entered much further into the cochlea. Confocal images disclosed fragments of neurons scattered in the gliotic tissue. In the cochlear nucleus, hypertrophic astrocytic processes were abundant around the soma of the neurons. The transverse diameter of the auditory nerve at and proximal to the compression site was considerably reduced, indicating atrophy, especially in rats in which the auditory nerve was profoundly compressed. Conclusions The authors found for the first time that mechanical stress to the auditory nerve causes substantial reactive gliosis in both the peripheral and central auditory pathways within 1–8 weeks. Progressive reactive gliosis following surgical stress may cause dysfunction in the auditory pathways and may be a primary cause of progressive hearing loss following microsurgical treatment for VS.


The author enters into a minute anatomical investigation of the structure of the spinal cord, and of its relations with the encephalon, and with the origins of the nerves. He finds that the spinal cord is constituted, in its whole length, by six pairs of columns, namely, two posterior, two lateral, and two anterior; each column being composed of concentric layers, and invested with an external coating of cineritious substance, and all the columns being divided from each other by deep sulci, which penetrate nearly to the centre of the cord. On tracing the posterior columns in their ascent towards the encephalon, they are seen to diverge laterally at the calamus scriptorius , or bottom of the fourth ventricle, and to proceed into the substance of the cerebellum. Each of these posterior columns is here found to consist of two portions, the outermost being the largest; and they now constitute the processus cerebelli ad medu oblongatam . This subdivision of the posterior columns may be traced throughout the whole length of the spinal cord. The lateral columns give origin to the posterior roots of the spinal nerves, and are therefore the parts subservient to sensation. In ascending towards the brain, each of these columns has a double termination; first, in the root of the fifth pair of cephalic nerves; and secondly, in the place where both columns unite into one round cord, and mutually decussate. Between the lateral and the anterior columns there is interposed a layer of cineritious matter, constituting a continuous stratum from the cauda equina to the roots of the auditory nerves. There is also a septum, dividing the right and left tracts subservient to sensation in the region of the fourth ventricle, and apparently terminating at the point of decussation of these tracts; but, in reality, separating to allow of this decussation, and joining the central portion of the cord, which connects the posterior with the anterior columns, and extends from the pons Varolii to the cauda equina .


2017 ◽  
Author(s):  
Hongsun Guo ◽  
Mark Hamilton ◽  
Sarah J. Offutt ◽  
Cory D. Gloeckner ◽  
Tianqi Li ◽  
...  

SummaryUltrasound (US) can noninvasively activate intact brain circuits, making it a promising neuromodulation technique. However, little is known about the underlying mechanism. Here, we apply transcranial US and perform brain mapping studies in guinea pigs using extracellular electrophysiology. We find that US elicits extensive activation across cortical and subcortical brain regions. However, transection of the auditory nerves or removal of cochlear fluids eliminates the US-induced activity, revealing an indirect auditory mechanism for US neural activation. US likely vibrates the cerebrospinal fluid in the brain, which is continuous with the fluid in the cochlea via cochlear aqueducts; thus, US can activate the ascending auditory pathways and other non-auditory regions through cross-modal projections. This finding of a cochlear fluid-induced vibration mechanism challenges the idea that US can directly activate neurons in the intact brain, suggesting that future US stimulation studies will need to control for this effect to reach reliable conclusions.


2020 ◽  
Vol VIII (3) ◽  
pp. 1-15
Author(s):  
N. A. Vyrubov

The anatomy of the facial and auditory nerves, thanks to a whole series of studies produced according to all sorts of methods, seems at the present time very thoroughly developed; but while the method of degeneration (with peripheral lesions) has already understood many connections of the facial nerve in a person, it has not yet been possible to observe sufficiently extensive degenerations in the medulla oblongata and tubercles of the quadruple due to damage to the peripheral auditory canals. It is in this last relationship that the case I have studied is of interest, although it should be noted that for the anatomy of the facial nerve, he also understood some still unknown relationship.


Author(s):  
Lyudmila N. Shapoval ◽  
Olga Dmytrenko ◽  
Galyna L. Vavilova ◽  
Lyudmila S. Pobegaylo ◽  
Lyubov G. Stepanenko ◽  
...  

Author(s):  
Lyudmila M. Shapoval ◽  
Bogdan S. Kop'yak ◽  
Olga V. Dmytrenko ◽  
Volodymyr O. Mayskiy ◽  
Olena P. Mankivska ◽  
...  

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