scholarly journals Functional dyspepsia and chronic gastritis

2018 ◽  
Vol 9 (1) ◽  
pp. 77-83 ◽  
Author(s):  
Yury P. Uspenskiy ◽  
Natalia V. Baryshnikova

Diseases of upper parts of digestive tract are extremely widespread pathology and have not only the medical, but also social importance since often occur at young working-age people. It is actual to separate the items: functional dyspepsia (FD) and a dyspepsia associated with Helicobacter pylori because it is important for optimization of patient’s treatment. The review of modern foreign and Russian references about treatment of dyspeptic patients depending on existence or absence of an infection of Helicobacter pylori is presented in article (recommendation of V Maastricht consensus, Kyoto consensus, Russian gastroenterological association, Science society of Russian gastroenterologists). At diagnosis of a functional dyspepsia, it is recommended to be guided by the Roman criteria of the IV revision. In with document not only importance of an exception of organic pathology of digestive tract as the reasons of a secondary dyspepsia, but also need of inspection for the purpose of verification of Helicobacter pylori for an exception of an etiological role of a microorganism in development of a dyspepsia is emphasized. Allocation of two clinical options of a functional dyspepsia is also proved from the point of view of approaches to therapy of this disease. Algorithms of treatment of patients with various options of a dyspepsia are presented in article. These algorithms include different schemes of eradication therapy in case of dyspepsia associated with Helicobacter pylori and prokinetics/acid suppressors in case of functional dyspepsia.

2017 ◽  
Vol 37 (3) ◽  
pp. 57-63
Author(s):  
Y. S. Tsimmerman

The article provides a detailed analysis of the provisions of the Kyoto consensus on the classification of chronic gastritis. Particular attention is paid to the etiological role of Helicobacter pylori. The authors presented the results of their own study of the microbial “landscape” of the gastric mucosa. The role of Helicobacter pylori, atrophy and metaplasia of the gastric mucosa in the development of gastric cancer, as well as other etiological variants of chronic gastritis: alcoholic, medicinal, etc. are discussed. Critical assessment of the main provisions of the Kyoto consensus was made.


2007 ◽  
Vol 25 (3) ◽  
pp. 203-205 ◽  
Author(s):  
Dino Vaira ◽  
Chiara Ricci ◽  
Alberto Lanzini ◽  
Federico Perna ◽  
Antonio Romano ◽  
...  

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 1747 ◽  
Author(s):  
David R. Scott ◽  
George Sachs ◽  
Elizabeth A. Marcus

Infection of the stomach by the gastric pathogen Helicobacter pylori results in chronic active gastritis and leads to the development of gastric and duodenal ulcer disease and gastric adenocarcinoma. Eradication of H. pylori infection improves or resolves the associated pathology. Current treatments of H. pylori infection rely on acid suppression in combination with at least two antibiotics. The role of acid suppression in eradication therapy has been variously attributed to antibacterial activity of proton pump inhibitors directly or through inhibition of urease activity or increased stability and activity of antibiotics. Here we discuss the effect of acid suppression on enhanced replicative capacity of H. pylori to permit the bactericidal activity of growth-dependent antibiotics. The future of eradication therapy will rely on improvement of acid inhibition along with current antibiotics or the development of novel compounds targeting the organism’s ability to survive in acid.


Helicobacter ◽  
2007 ◽  
Vol 12 (6) ◽  
pp. 605-608 ◽  
Author(s):  
Lea Veijola ◽  
Aino Oksanen ◽  
Auli Linnala ◽  
Pentti Sipponen ◽  
Hilpi Rautelin

2020 ◽  
Vol 57 (1) ◽  
pp. 74-78 ◽  
Author(s):  
Carine LEITE ◽  
Luiz Edmundo MAZZOLENI ◽  
Diego de Mendonça UCHOA ◽  
Juliana Araújo CASTANHO ◽  
Felipe MAZZOLENI ◽  
...  

ABSTRACT BACKGROUND: The role of Helicobacter pylori infection on eosinophilic infiltration in duodenal mucosa is poorly studied. An increase in the number of eosinophils in duodenum has been associated with functional dyspepsia. OBJECTIVE: To evaluate the influence of H. pylori infection on duodenal eosinophil count and the role of eosinophilic infiltrate of duodenum in functional dyspepsia. METHODS: Positive and negative H. pylori individuals were included. Both functional dyspeptic patients according to Rome III criteria (cases) and individuals without gastrointestinal symptoms (controls) were enrolled. They were submitted to upper endoscopy and H. pylori infection was verified by gastric histopathology and urease test. Eosinophils in the duodenal mucosa were counted in five high-power fields, randomly selected on slides of endoscopic biopsies. RESULTS: Thirty-nine H. pylori positive (mean age 40.5 and 69.2% women) and 24 negative patients (mean age 37.3 and 75% women) were included. The influence of the infection was observed in the duodenal eosinophil count, which was higher in infected individuals: median 13.2 vs 8.1 in non-infected individuals (P=0.005). When we analyzed patients according to symptoms, cases - mean age 39.6; 71.4% women - and controls - mean age 38.7; 71.4% women - had similar duodenal eosinophil count: median 11.9 and 12.6 respectively (P=0.19). CONCLUSIONS: We did not demonstrate association of duodenal eosinophil count with functional dyspepsia but found association with H. pylori infection.


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