Activation of V2 vasopressin receptors induces recovery of motor function in patients with stroke, Parkinson’s disease and parkinsonism of different nature

In clinical trials have studied effectiveness of agonist of V2 vasopressin receptors, 1-dezamino-8-D-arginine-vasopressin (DDAVP) in correction of movement disorders in patients with stroke, Parkinson’s disease and parkinsonism. Therapy received 15 patients with the stroke and 21 patients with the Parkinson’s disease and parkinsonism. Positive effect of therapy was observed in 67% of cases of stroke and in 73% cases of parkinsonian syndrome. After therapy of DDAVP movement disorders were regressed in patients with light hemiparesis after stroke. In patients with a tremor-rigid shape and akinetic-rigid form of the disease major movement disorders: tremor, rigidity, bradykinesia and hypokinesia were regressed. Except the disorders of movements affective and cognitive abnormalities were decreased. There was established that DDAVP effective in correction of disorders of voluntary and involuntary component of movements function in patients with the focal vascular and neurodegenerative diseases.

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P.066 Intrajejunal levodopa infusion (ILI) for Parkinson’s Disease (PD): a Canadian experience

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/cjn.2017.150 ◽

2017 ◽

Vol 44 (S2) ◽

pp. S30-S30

Author(s):

P Podgorny ◽

P McCann ◽

K Toore ◽

G Tremain ◽

A Lazarescu ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Motor Function ◽

Movement Disorders ◽

Chart Review ◽

Canadian Experience ◽

Jejunal Tube ◽

Minimal Benefit

Background: ILI has been in use in Canada since 2011 to treat advanced PD. We review the benefits and complications of ILI for PD in a tertiary movement disorders center in Canada. Methods: Detailed chart review of patients treated with ILI at including motor UPDRS scores, ILI pump and PEG-J tube complications. Patients and caregivers were interviewed at regular clinic follow up about their experience with ILI. Results: 13 patients received ILI [10M, 3F; mean age 65.6 yrs, range (51.8-79.5); PD duration 14.2 yrs, range (9.1-22.0); mean follow-up 1.8 yrs, range (0.2-4.8)]. Patients reported improvement in motor function, decreased dyskinesias and ‘OFF times’ [mean motor UPDRS: pre-ILI 37.1, 1-6months post-ILI 27.5]. Common complications included dislodgement, knotting or blockage of the jejunal tube extension requiring endoscopic re- insertion (29 incidents in 6 patients over 5 yrs). Four patients discontinued Duodopa treatment, for reasons of declining cognition, inability to care for the pump, and/or minimal benefit. Conclusions: ILI is useful for the treatment of advanced PD, in patients that can care for the pump apparatus.

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The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson’s disease

Brain ◽

10.1093/brain/awp328 ◽

2010 ◽

Vol 133 (2) ◽

pp. 482-495 ◽

Cited By ~ 83

Author(s):

Shane Grealish ◽

Marie E. Jönsson ◽

Meng Li ◽

Deniz Kirik ◽

Anders Björklund ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Motor Function ◽

Rat Model ◽

Important Determinant ◽

Dopamine Neuron ◽

Ventral Mesencephalon ◽

Recovery Of Motor Function

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Effectiveness of Music Therapy for the Treatment of Movement Disorders in Parkinson’s Disease

10.5327/1516-3180.705 ◽

2021 ◽

Author(s):

Emily Calmon Londero ◽

Ana Beatriz Cazé Cerón

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Clinical Trials ◽

Music Therapy ◽

Sample Size ◽

Movement Disorders ◽

Randomized Clinical Trials ◽

Small Sample ◽

Motor Deficit ◽

Auditory Stimuli

Introduction: Body movement is synchronized by external rhythmic stimuli in conjunction with physiological control, based on an internal timing process. In this perspective, music therapy can be a potential therapeutic tool for the treatment of individuals with movement disorders as it bypasses an internal rhythm motor deficit. Objective: To evaluate the benefit of music therapy in the treatment of movement disorders in patients with Parkinson’s disease (PD). Methods: This study is a literary review, which used the PubMed platform, in April 2021, with the formula: (MOVEMENT DISORDERS) AND (MUSIC THERAPY). As search criteria, articles were selected from meta-analyzes, reviews and randomized clinical trials, published in the last 10 years, in English and studies carried out in humans. Results: 21 articles were found, 6 articles were selected according to the eligibility criteria. Most studies show an improvement in movement disorders when rhythmic musical stimuli are associated with motor interventions, such as the use of treadmills. A randomized clinical trial with 50 patients with idiopathic PD was divided into two groups, one with a treadmill and with rhythmic auditory stimuli and another with a treadmill and without auditory stimuli. Among the outcomes analyzed, the improvement in movement speed was the most beneficial aspect, with an improvement in quality of life and cognitive functions. Conclusion: It is evident that the use of music therapy in the treatment of movement disorders in patients with PD improves motor symptoms. However, the studies have a small sample size and differ in terms of the method of music therapy, the period of intervention and the scales used to assess improvement. Therefore, it is important that randomized, multicenter clinical trials with a larger sample size are carried out to prove the benefits of music therapy in a patient with Parkinson’s disease.

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