scholarly journals BEARING TOOLS MACHINING AND NEW EXPERIMENTAL EXPRESSION OF DURABILITY DEPENDENCE FOR SINTERED CARBIDE CUTTING

2016 ◽  
Vol 2016 (04) ◽  
Author(s):  
Anton Panda ◽  
Jan Duplak ◽  
Michal Hatala ◽  
Rudolf Kasinec ◽  
Jozef Steranka
Keyword(s):  
Sintered Carbide ◽  
Experimental Expression

EDM-Machining of Sintered Carbide Compacting Dies

CIRP Annals ◽  
1988 ◽  
Vol 37 (1) ◽  
pp. 175-178 ◽  
Author(s):  
G.N. Levy ◽  
R. Wertheim
Keyword(s):  
Sintered Carbide

scholarly journals Cloning and characterization of chicken α5 integrin: Endogenous and experimental expression in early chicken embryos

2013 ◽  
Vol 32 (7-8) ◽  
pp. 381-386 ◽  
Author(s):  
Yukinori Endo ◽  
Hiroko Ishiwata-Endo ◽  
Kenneth M. Yamada
Keyword(s):  
Chicken Embryos ◽  
Experimental Expression

scholarly journals KIT ligand protects against both light-induced and genetic photoreceptor degeneration

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Huirong Li ◽  
Lili Lian ◽  
Bo Liu ◽  
Yu Chen ◽  
Jinglei Yang ◽  
...  
Keyword(s):  
Photoreceptor Cells ◽  
Nuclear Accumulation ◽  
Tyrosine Kinase Receptor ◽  
Light Damage ◽  
Photoreceptor Degeneration ◽  
Kit Mutation ◽  
Kit Ligand ◽  
Retinal Degenerative Diseases ◽  
Experimental Expression ◽  
Inherited Retinal Degeneration

Photoreceptor degeneration is a major cause of blindness and a considerable health burden during aging but effective therapeutic or preventive strategies have not so far become readily available. Here, we show in mouse models that signaling through the tyrosine kinase receptor KIT protects photoreceptor cells against both light-induced and inherited retinal degeneration. Upon light damage, photoreceptor cells upregulate Kit ligand (KITL) and activate KIT signaling, which in turn induces nuclear accumulation of the transcription factor NRF2 and stimulates the expression of the antioxidant gene Hmox1. Conversely, a viable Kit mutation promotes light-induced photoreceptor damage, which is reversed by experimental expression of Hmox1. Furthermore, overexpression of KITL from a viral AAV8 vector prevents photoreceptor cell death and partially restores retinal function after light damage or in genetic models of human retinitis pigmentosa. Hence, application of KITL may provide a novel therapeutic avenue for prevention or treatment of retinal degenerative diseases.

Rules of wear of sintered carbide concentrators in ultrasonic machining of a nitride ceramic

1985 ◽  
Vol 24 (4) ◽  
pp. 333-337
Author(s):  
M. S. Koval'chenko ◽  
A. V. Paustovskii ◽  
V. A. Perevyazko
Keyword(s):  
Ultrasonic Machining ◽  
Sintered Carbide

scholarly journals Simulation and visualization of multiple KEGG pathways using BioNSi

F1000Research ◽  
2018 ◽  
Vol 6 ◽  
pp. 2120
Author(s):  
Adva Yeheskel ◽  
Adam Reiter ◽  
Metsada Pasmanik-Chor ◽  
Amir Rubinstein
Keyword(s):  
Network Simulation ◽  
Expression Data ◽  
Proof Of Concept ◽  
Pathway Database ◽  
Simulation Tools ◽  
Kegg Pathways ◽  
Kegg Pathway Database ◽  
Disease Condition ◽  
Inflammatory Bowel ◽  
Experimental Expression

Motivation: Many biologists are discouraged from using network simulation tools because these require manual, often tedious network construction. This situation calls for building new tools or extending existing ones with the ability to import biological pathways previously deposited in databases and analyze them, in order to produce novel biological insights at the pathway level. Results: We have extended a network simulation tool (BioNSi), which now allows merging of multiple pathways from the KEGG pathway database into a single, coherent network, and visualizing its properties. Furthermore, the enhanced tool enables loading experimental expression data into the network and simulating its dynamics under various biological conditions or perturbations. As a proof of concept, we tested two sets of published experimental data, one related to inflammatory bowel disease condition and the other to breast cancer treatment. We predict some of the major observations obtained following these laboratory experiments, and provide new insights that may shed additional light on these results. Tool requirements: Cytoscape 3.x, JAVA 8 Availability: The tool is freely available at http://bionsi.wix.com/bionsi, where a complete user guide and a step-by-step manual can also be found.

scholarly journals Experimental Expression of the Tangential Micro-displacement between Joint Surfaces

1979 ◽  
Vol 22 (166) ◽  
pp. 591-597
Author(s):  
Tadayoshi KOIZUMI ◽  
Yoshimi ITO ◽  
Masami MASUKO
Keyword(s):  
Joint Surfaces ◽  
Experimental Expression

scholarly journals Homology Modeling and Optimized Expression of Truncated IK Protein, tIK, as an Anti-Inflammatory Peptide

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4358
Author(s):  
Yuyoung Song ◽  
Minseon Kim ◽  
Yongae Kim
Keyword(s):  
Rheumatoid Arthritis ◽  
Side Effects ◽  
Homology Modeling ◽  
Protein A ◽  
Interleukin 10 ◽  
Current Treatment ◽  
Pharmaceutical Drugs ◽  
Negative Effects ◽  
Anti Inflammatory ◽  
Experimental Expression

Rheumatoid arthritis, caused by abnormalities in the autoimmune system, affects about 1% of the population. Rheumatoid arthritis does not yet have a proper treatment, and current treatment has various side effects. Therefore, there is a need for a therapeutic agent that can effectively treat rheumatoid arthritis without side effects. Recently, research on pharmaceutical drugs based on peptides has been actively conducted to reduce negative effects. Because peptide drugs are bio-friendly and bio-specific, they are characterized by no side effects. Truncated-IK (tIK) protein, a fragment of IK protein, has anti-inflammatory effects, including anti-rheumatoid arthritis activity. This study focused on the fact that tIK protein phosphorylates the interleukin 10 receptor. Through homology modeling with interleukin 10, short tIK epitopes were proposed to find the essential region of the sequence for anti-inflammatory activity. TH17 differentiation experiments were also performed with the proposed epitope. A peptide composed of 18 amino acids with an anti-inflammatory effect was named tIK-18mer. Additionally, a tIK 9-mer and a 14-mer were also found. The procedure for the experimental expression of the proposed tIK series (9-mer, 14-mer, and 18-mer) using bacterial strain is discussed.

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