scholarly journals Development and Validation of Spectrophotometric Methods for the Quantification of Solifenacin Succinate: Application to Tablet Dosage Forms

2013 ◽  
Vol 15 ◽  
pp. 167-182
Author(s):  
Burla Sunitha Venkata Seshamamba ◽  
Peruri Veera Venkata Satyanarayana ◽  
Chandra Bala Sekaran
Keyword(s):  
Ammonium Thiocyanate ◽  
Dosage Forms ◽  
Ion Pair ◽  
Ammonium Molybdate ◽  
Ternary Complexes ◽  
Bromocresol Green ◽  
Spectrophotometric Methods ◽  
Solifenacin Succinate ◽  
Development And Validation ◽  
Tablet Dosage

Four sensitive, precise and accurate spectrophotometric methods for the estimation of solifenacin succinate (SFS) have been developed. Method A describes the interaction of SFS with potassium permanganate in alkaline medium to give green colored manganate ion with absorption maxima at 610 nm. Methods B and C are based on the formation of ternary complexes of SFS with, copper (II)/eosin (method B) and ammonium molybdate/ammonium thiocyanate (method C), respectively which are extracted into chloroform and have absorption maxima at 545 nm (method B) and 465 nm (method C). Method D was based on the formation of yellow colored ion-pair complex between bromocresol green and SFS in dichloromethane medium with absorption maxima at 415 nm. Regression analysis of Beer's law plot showed good correlation in the concentration range of 5-50, 2.5-50, 10-100 and 2-20 μg/mL for methods A, B, C and D, respectively. Different variables affecting the reaction were studied and optimized. The proposed methods were applied successfully for the analysis of SFS in tablets dosage forms. No interference was observed from common pharmaceutical excipients.

scholarly journals Development and Validation of Spectrophotometric Methods for the Estimation of Mesalamine in Tablet Dosage Forms

2010 ◽  
Vol 2 (3) ◽  
pp. 284-288 ◽  
Author(s):  
K.M. Patel ◽  
C.N. Patel ◽  
B. Panigrahi ◽  
A.S. Parikh ◽  
H.N. Patel
Keyword(s):  
Dosage Forms ◽  
Spectrophotometric Methods ◽  
Development And Validation ◽  
Tablet Dosage

scholarly journals Validated Extractive Spectrophotometric Estimation of Tadalafil in Tablet Dosage Form

2009 ◽  
Vol 6 (3) ◽  
pp. 611-614
Author(s):  
J. Adlin Jino Nesalin ◽  
C. Jose Gnana Babu ◽  
G. Vijaya Kumar ◽  
T. Tamizh Mani
Keyword(s):  
Statistical Analysis ◽  
Dosage Form ◽  
Bromothymol Blue ◽  
Ion Pair ◽  
Routine Analysis ◽  
Bromocresol Green ◽  
Buffer Solution ◽  
Spectrophotometric Methods ◽  
Beer’S Law ◽  
Tablet Dosage

Two simple spectrophotometric methods have been developed for the estimation of tadalafil in both pure and tablet dosage form. Methods A and B are based on the formation of ion-pair complexes of the drug with dyes such as bromothymol blue (BTB) and bromocresol green (BCG) in acidic buffer solution followed by their extraction with chloroform to form yellow colored chromogen with absorption maxima at 420 nm and 415 nm respectively. Beer’s law is valid in the concentration range of 10-50 mcg/mL for both the methods. These developed methods were validated for precision, accuracy, ruggedness and robustness. Statistical analysis proves that the methods are reproducible and selective for the routine analysis of the said drug.

scholarly journals Spectrophotometric determination of tadalafil in pure and dosage forms

2011 ◽  
Vol 17 (2) ◽  
pp. 125-132 ◽  
Author(s):  
Kaf Al ◽  
Ayman Gouda
Keyword(s):  
Ion Pairs ◽  
Dosage Forms ◽  
Ion Pair ◽  
Bromocresol Purple ◽  
Buffer Solution ◽  
Spectrophotometric Methods ◽  
Basic Nitrogen ◽  
Accuracy And Precision ◽  
Tablet Dosage

Two simple, rapid, and extractive spectrophotometric methods were developed for the determination of tadalafil (TDF) in both pure and tablet dosage form. These methods are based on the formation of ion-pair complexes between the basic nitrogen of the drug with bromocresol purple (BCP) and methyl orange (MO) in acidic buffer solution. The formed complexes were extracted with chloroform and measured at 410 and 425 nm using BCP and MO, respectively. Beer?s law was obeyed in the range 2.0-20 ?g mL?1 with correlation coefficient (n = 6) ? 0.9996. The molar absorpitivity, Sandell sensitivity, detection and quantification limits were also calculated. The composition of the ion pairs was found 1:1 by Job?s method. The proposed methods have been applied successfully for the analysis of TDF in pure and in its dosage forms. These developed methods were validated for accuracy and precision.

scholarly journals The development and validation of visible spectrophotometric methods for simvastatin determination in pure and the tablet dosage forms

2008 ◽  
Vol 14 (3) ◽  
pp. 205-210 ◽  
Author(s):  
Kanakapura Basavaiah ◽  
Kalsang Tharpa
Keyword(s):  
Acid Medium ◽  
Standard Addition ◽  
Dosage Forms ◽  
Spectrophotometric Methods ◽  
Red Color ◽  
Assay Precision ◽  
Development And Validation ◽  
Tablet Dosage

Two simple and sensitive spectrophotometric methods have been developed for the determination of simvastatin (SMT) in pure form and in tablets using insitu generated bromine, and p-phenylenediamine (PPDA) or o-dianisidine (ODA) as reagents. The methods are based on the bromination of SMT by a measured excess of in situ bromine in acid medium followed by the determination of unreacted bromine by reacting with PPDA and measuring the resulting red color at 510 nm (method A) or reacting with ODA and measuring the absorbance at 470 nm (method B). The conditions for the assay have been optimized. Beer's law is obeyed over the concentration ranges 20-120 and 2-12 ?g/ml for method A and method B, respectively. The calculated molar absorbtivities are 2.24?103 and 1.91?104 dm3 mol-1 cm-1 for the method A and the method B, respectively; 0.1868 and 0.0115 ?g/cm2 being the corresponding Sandell sensitivities. The LOD and LOQ for method A are found to be 2.96 and 8.97 ?g/ml, and the respective values for method B are 0.14 and 0.42 ?g/ml. The intra-day and inter-day precision and accuracies were checked. The assay precision was less than 5 % CV and the accuracy was 97.38-103.4 %. The methods were used for the determination of SMT in tablets. No interference from the excipients added to tablets was found. The accuracy and validity of the methods were further ascertained by recovery studies via the standard addition technique.

Method Development and Validation of Spectrophotometric Methods for The Estimation of Rizatriptan Benzoate in Pure and Pharmaceutical Dosage Form

2021 ◽  
pp. 6003-6006
Author(s):  
Pushpa Latha E. ◽  
Sailaja B.
Keyword(s):  
Dosage Form ◽  
Method Development ◽  
Limit Of Detection ◽  
Limit Of Quantification ◽  
Pharmaceutical Dosage Form ◽  
Rizatriptan Benzoate ◽  
Spectrophotometric Methods ◽  
Ich Guidelines ◽  
Development And Validation ◽  
Tablet Dosage

Analytical UV derivative spectrophotometric method was developed and validated to quantify Rizatriptan Benzoate in pure drug and tablet dosage form. Based on the spectrophotometric characteristics of Rizatriptan Benzoate, a signal of zero (225nm), first (216nm), second (237nm), third (233nm), fourth (231nm) order derivative spectra were found to be adequate for quantification. The methods obeyed Beer's law in the concentration range of (0.1-360µg/ml) with square correlation coefficient (r2) of 0.999. The mean percentage recovery was found to be 100.01 ± 0.075. As per ICH guidelines the results of the analysis were validated in terms of linearity, precision, accuracy, limit of detection and limit of quantification, and were found to be satisfactory.

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