scholarly journals Validated Extractive Spectrophotometric Estimation of Tadalafil in Tablet Dosage Form

2009 ◽  
Vol 6 (3) ◽  
pp. 611-614
Author(s):  
J. Adlin Jino Nesalin ◽  
C. Jose Gnana Babu ◽  
G. Vijaya Kumar ◽  
T. Tamizh Mani
Keyword(s):  
Statistical Analysis ◽  
Dosage Form ◽  
Bromothymol Blue ◽  
Ion Pair ◽  
Routine Analysis ◽  
Bromocresol Green ◽  
Buffer Solution ◽  
Spectrophotometric Methods ◽  
Beer’S Law ◽  
Tablet Dosage

Two simple spectrophotometric methods have been developed for the estimation of tadalafil in both pure and tablet dosage form. Methods A and B are based on the formation of ion-pair complexes of the drug with dyes such as bromothymol blue (BTB) and bromocresol green (BCG) in acidic buffer solution followed by their extraction with chloroform to form yellow colored chromogen with absorption maxima at 420 nm and 415 nm respectively. Beer’s law is valid in the concentration range of 10-50 mcg/mL for both the methods. These developed methods were validated for precision, accuracy, ruggedness and robustness. Statistical analysis proves that the methods are reproducible and selective for the routine analysis of the said drug.

scholarly journals Validated Spectrophotometric Estimation of Famciclovir in Tablet Dosage Form

2009 ◽  
Vol 6 (3) ◽  
pp. 780-784 ◽  
Author(s):  
J. Adlin Jino Nesalin ◽  
C. Jose Gnana Babu ◽  
G. Vijaya Kumar ◽  
T. Tamizh Mani
Keyword(s):  
Statistical Analysis ◽  
Acidic Medium ◽  
Dosage Form ◽  
Ion Pair ◽  
Alizarin Red S ◽  
Routine Analysis ◽  
Orange Ii ◽  
Alizarin Red ◽  
Spectrophotometric Methods ◽  
Tablet Dosage

Two simple and sensitive spectrophotometric methods have been developed for the estimation of Famciclovir (FCR) in bulk and tablet dosage form. Methods A and B are based on the formation of ion-pair complexes of the drug with dyes such as orange II (OG-II) and alizarin red S (AR-S) in acidic medium followed by their extraction with chloroform to give colored chromogen with absorption maxima at 480 nm and 440 nm respectively. Beer’s law is valid in the concentration range of 2-10 mcg/mL for both the methods. These developed methods were validated for precision, accuracy, ruggedness and robustness. Statistical analysis proves that the methods are reproducible and selective for the routine analysis of the said drug.

scholarly journals Spectrophotometric Determination of Zidovudine in Pharmaceutical Dosage Forms

2012 ◽  
Vol 9 (1) ◽  
pp. 89-92
Author(s):  
J. Sudhakar Reddy ◽  
MD. S. Maqsood Ahmed ◽  
I. E. Chakravarthy ◽  
K. Prabhavathi
Keyword(s):  
Statistical Analysis ◽  
Dosage Form ◽  
Dosage Forms ◽  
Ion Pair ◽  
Reagent Blank ◽  
Pharmaceutical Dosage Forms ◽  
Extractable Complex ◽  
Bulk Drug ◽  
Tablet Dosage

A simple, sensitive and economical spectrophotometric method has been developed for the determination of zidovudine in commercial dosage forms. The method was based on the formation of chloroform extractable complex of zidovudine with wool fast blue. The absorbance of the extractable ion pair complex is measured at the wavelength of maximum absorbance 590 nm against the reagent blank treated similarly. Statistical analysis proves that the proposed methods are reproducible and selective for the estimation of zidovudine in bulk drug and in its tablet dosage form.

scholarly journals Spectrophotometric Determination of Certain Antidepressants in Pharmaceutical Preparations

2006 ◽  
Vol 89 (4) ◽  
pp. 966-971 ◽  
Author(s):  
ArmaĞan Önal ◽  
Ş. Evrim Kepeki ◽  
S MÜge Çetin ◽  
Sidika ErtÜrk
Keyword(s):  
High Performance ◽  
Pharmaceutical Preparations ◽  
Bromothymol Blue ◽  
Molar Absorptivity ◽  
Ion Pair ◽  
Bromocresol Green ◽  
Bromophenol Blue ◽  
Spectrophotometric Methods ◽  
Drug Substances

Abstract Simple and reproducible spectrophotometric methods have been developed for determination of sertraline, fluoxetine, and venlafaxine in pharmaceutical preparations. The methods are based on the reactions between the studied drug substances and ion-pair agents (bromothymol blue, bromocresol green, or bromophenol blue) to produce yellow-colored ion-pair complexes in acidic buffers. After extracting in chloroform, the ion-pair complexes are spectrophotometrically determined at the optimum wavelength. Optimizations of the reaction conditions were carried out. Beer's law was obeyed within the concentration range from 1 to 15 μg/mL. The molar absorptivity, Sandell sensitivity, and detection and quantification limits were also determined. The developed methods were applied successfully for the determination of these drugs in some available commercial preparations. The results were compared statistically with those obtained from reported high-performance liquid chromatography methods.

scholarly journals Non-extractive spectrophotometric determination of valsartan in pure form and in pharmaceutical products by ion-pair complex formation with bromophenol blue and methyl red

Pharmacia ◽  
2021 ◽  
Vol 68 (4) ◽  
pp. 851-858
Author(s):  
Kateryna Peleshok ◽  
Bohdana Bondar ◽  
Liubomyr Kryskiw ◽  
Tetyana Kucher ◽  
Olha Poliak ◽  
...  
Keyword(s):  
Pharmaceutical Products ◽  
Ion Pair ◽  
Bromophenol Blue ◽  
Methyl Red ◽  
Spectrophotometric Methods ◽  
Accuracy And Precision ◽  
Beer's Law ◽  
Beer’S Law ◽  
Coloured Complex ◽  
Tablet Dosage

Two simple, rapid, green non extractive spectrophotometric methods are described for the estimation of valsartan in tablet dosage form. The determination is based on the ion-pair formation using the dyes, bromophenol blue (BPB) and methyl red (MR). Valsartan forms ion-pair complex selectively with the dyes, as indicated by the formation of a coloured complex with BPB at pH 5.5 with λmax at 424 nm and MR at pH 4.3 with λmax at 494 nm. For both methods, optimal spectrophotometric conditions were established. The linear relationship was found between absorbance at λmax and concentration of drug in the range 8–24 µg/mL for BPB and 4–20 µg/mL for MR. Regression analysis of Beer’s law plot at 424 nm yielded the regression equation, y = 0.0102x + 01636 (BPB) and at 494 nm y = 0.0222x – 0.0063 (MR). High values of correlations coefficient (R2 = 0.9988 (BPB) and R2 = 0.9991 (MR)) and small values of intercept validated the linearity of calibration curve and obedience to Beer’s law. The LOD and LOQ values were calculated to be 1.03 µg/mL and 3.43 µg/mL respectively (BPB) and 0.68 µg/mL and 2.26 µg/mL respectively (MR). Intra-day and inter-day accuracy and precision, robustness were in acceptable limits. The proposed methods were applied for the quantification of valsartan in tablets pertaining to three commercial formulations. Analytical eco-scale for greenness assessment of the proposed spectrophotometric methods showed that both methods corresponds to excellent green analysis with a score of 89.

scholarly journals Development and Validation of Spectrophotometric Methods for the Quantification of Solifenacin Succinate: Application to Tablet Dosage Forms

2013 ◽  
Vol 15 ◽  
pp. 167-182
Author(s):  
Burla Sunitha Venkata Seshamamba ◽  
Peruri Veera Venkata Satyanarayana ◽  
Chandra Bala Sekaran
Keyword(s):  
Ammonium Thiocyanate ◽  
Dosage Forms ◽  
Ion Pair ◽  
Ammonium Molybdate ◽  
Ternary Complexes ◽  
Bromocresol Green ◽  
Spectrophotometric Methods ◽  
Solifenacin Succinate ◽  
Development And Validation ◽  
Tablet Dosage

Four sensitive, precise and accurate spectrophotometric methods for the estimation of solifenacin succinate (SFS) have been developed. Method A describes the interaction of SFS with potassium permanganate in alkaline medium to give green colored manganate ion with absorption maxima at 610 nm. Methods B and C are based on the formation of ternary complexes of SFS with, copper (II)/eosin (method B) and ammonium molybdate/ammonium thiocyanate (method C), respectively which are extracted into chloroform and have absorption maxima at 545 nm (method B) and 465 nm (method C). Method D was based on the formation of yellow colored ion-pair complex between bromocresol green and SFS in dichloromethane medium with absorption maxima at 415 nm. Regression analysis of Beer's law plot showed good correlation in the concentration range of 5-50, 2.5-50, 10-100 and 2-20 μg/mL for methods A, B, C and D, respectively. Different variables affecting the reaction were studied and optimized. The proposed methods were applied successfully for the analysis of SFS in tablets dosage forms. No interference was observed from common pharmaceutical excipients.

scholarly journals Spectrophotometric determination of tadalafil in pure and dosage forms

2011 ◽  
Vol 17 (2) ◽  
pp. 125-132 ◽  
Author(s):  
Kaf Al ◽  
Ayman Gouda
Keyword(s):  
Ion Pairs ◽  
Dosage Forms ◽  
Ion Pair ◽  
Bromocresol Purple ◽  
Buffer Solution ◽  
Spectrophotometric Methods ◽  
Basic Nitrogen ◽  
Accuracy And Precision ◽  
Tablet Dosage

Two simple, rapid, and extractive spectrophotometric methods were developed for the determination of tadalafil (TDF) in both pure and tablet dosage form. These methods are based on the formation of ion-pair complexes between the basic nitrogen of the drug with bromocresol purple (BCP) and methyl orange (MO) in acidic buffer solution. The formed complexes were extracted with chloroform and measured at 410 and 425 nm using BCP and MO, respectively. Beer?s law was obeyed in the range 2.0-20 ?g mL?1 with correlation coefficient (n = 6) ? 0.9996. The molar absorpitivity, Sandell sensitivity, detection and quantification limits were also calculated. The composition of the ion pairs was found 1:1 by Job?s method. The proposed methods have been applied successfully for the analysis of TDF in pure and in its dosage forms. These developed methods were validated for accuracy and precision.

scholarly journals Spectrophotometric Determination of Trimebutine Through Ion- Pair and Charge- Transfer Complexation Reactions

2002 ◽  
Vol 70 (4) ◽  
pp. 341-351 ◽  
Author(s):  
Khalil Shaban M.
Keyword(s):  
Charge Transfer ◽  
Bromothymol Blue ◽  
Ion Pair ◽  
Bromocresol Green ◽  
Bromophenol Blue ◽  
Basic Drug ◽  
Yellow Colour ◽  
Spectrophotometric Methods ◽  
Relative Standard ◽  
Complexation Reactions

Summary Two simple and sensitive spectrophotometric methods are described for the assay of trimebutine. The first method is based on the interaction of the basic drug in 1,2 dichloroethane with bromocresol green (BCG); bromophenol blue (BPB) and bromothymol blue (BTB) in the same solvent to produce a stable yellow ion-pair complexes , which absorbed at 410,406 and 405nm, respectively. The second method is based upon the interaction of the basic drug with iodine in 1,2 dichloroethane. The yellow colour formed due to the formation of charge-transfer complex showed two maxima absorbed at 292 and 362 nm. Beer's law obeyed for both methods and the relative standard deviations were found to be less than 1 %. The two methods can be applied to the analysis of tablets, with no evidence of interference from excipients. A more detailed investigation on the complex was made to its composition, association constant and free energy change.

Novel UV Spectrophotometric Method for the Quantitative Analysis of CefpodoximeProxetil in Pharmaceutical Formulations by First Derivative Technique

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Potdar S. S. ◽  
Karajgi S. R. ◽  
Simpi C. C. ◽  
Kalyane N. V.
Keyword(s):  
Quantitative Analysis ◽  
Spectrophotometric Method ◽  
Dosage Form ◽  
Pharmaceutical Formulations ◽  
First Derivative ◽  
Good Linearity ◽  
Beer's Law ◽  
Beer’S Law ◽  
Tablet Dosage ◽  
Ich Guideline

The spectrophotometric method for estimation of CefpodoximeProxetil employed first derivative amplitude UV spectrophotometric method for analysis using methanol as solvent for the drug. CefpodoximeProxetil has absorbance maxima at 235nm and obeys Beer’s law in concentration range 10-50µg/ml with good linearity i.e. r2 about 0.999. The recovery studies established accuracy of the proposed method; result validated according to ICH guideline. Results were found satisfactory and reproducible. The method was successfully for evaluation of CefpodoximeProxetil in tablet dosage form without interference of common excipients.

Method Development and Validation of Spectrophotometric Methods for The Estimation of Rizatriptan Benzoate in Pure and Pharmaceutical Dosage Form

2021 ◽  
pp. 6003-6006
Author(s):  
Pushpa Latha E. ◽  
Sailaja B.
Keyword(s):  
Dosage Form ◽  
Method Development ◽  
Limit Of Detection ◽  
Limit Of Quantification ◽  
Pharmaceutical Dosage Form ◽  
Rizatriptan Benzoate ◽  
Spectrophotometric Methods ◽  
Ich Guidelines ◽  
Development And Validation ◽  
Tablet Dosage

Analytical UV derivative spectrophotometric method was developed and validated to quantify Rizatriptan Benzoate in pure drug and tablet dosage form. Based on the spectrophotometric characteristics of Rizatriptan Benzoate, a signal of zero (225nm), first (216nm), second (237nm), third (233nm), fourth (231nm) order derivative spectra were found to be adequate for quantification. The methods obeyed Beer's law in the concentration range of (0.1-360µg/ml) with square correlation coefficient (r2) of 0.999. The mean percentage recovery was found to be 100.01 ± 0.075. As per ICH guidelines the results of the analysis were validated in terms of linearity, precision, accuracy, limit of detection and limit of quantification, and were found to be satisfactory.

DEVELOPMENT OF STABILATING INDICATING ANALYTICAL METHOD FOR FAMOTIDINE AND DICLOFENAC POTASSIUM IN COMBINED DOSAGE FORM

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (06) ◽  
pp. 40-42
Author(s):  
D. R. Chaple ◽  
◽  
S. A Mehta ◽  
M. P Yeole ◽  
P. S. Tarte
Keyword(s):  
Analytical Method ◽  
Dosage Form ◽  
Simultaneous Equation ◽  
Routine Analysis ◽  
Simultaneous Estimation ◽  
Tablet Dosage

This work deals with the simultaneous estimation of famotidine and diclofenac potassium in a tablet dosage form. The method employed is simultaneous equation. The absorption maxima at 266 nm and 286 nm were used for the estimation of famotidine and diclofenac, respectively. Both the drugs and their mixture obey Beer-Lamberts law at selected wavelength in given concentration range. The result of analysis has been validated statistically and recovery studies confirmed the accuracy of the proposed method. The proposed method is simple, rapid, precise and accurate. It is used for the routine analysis of both drugs.

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