scholarly journals The synthesis and antimicrobial study of some azetidinone derivatives with the para-anisidine moiety

2007 ◽  
Vol 72 (5) ◽  
pp. 437-442 ◽  
Author(s):  
Ishwar Bhat ◽  
Sunil Chaithanya ◽  
P.D. Satyanarayana ◽  
Balakrishna Kalluraya
Keyword(s):  
1H Nmr ◽  
Spectroscopic Analysis ◽  
Aromatic Aldehydes ◽  
Chloroacetyl Chloride ◽  
Schiff’S Bases ◽  
Antimicrobial Study ◽  
Schiff's Bases ◽  
Agar Disc ◽  
Antifungal Potential ◽  
Antibacterial And Antifungal

Azetidinones were synthesized from p-anisidine in two steps. First the Schiff's bases were prepared by reacting the hydrazide of an anisidine derivative with different aromatic aldehydes. Cyclocondensation of the Schiff's bases with chloroacetyl chloride in the presence of triethylamine resulted in the formation of the corresponding azetidinone analogues. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR and mass spectroscopic analysis. The antibacterial and antifungal potential of the synthesized compounds were evaluated by the agar disc method.

scholarly journals Synthesis and Antimicrobial Activity of Some 1-arylideneamino-4-(4-chlorobenzylidene)-2-methyl- 1H-imidazolin-5(4H)-one Compounds

2019 ◽  
Vol 35 (2) ◽  
pp. 822-828
Author(s):  
Cong Tien Nguyen ◽  
Dao Thi Hong Dinh ◽  
Thin Van Nguyen ◽  
Giang Duc Le ◽  
Hien Cao Nguyen
Keyword(s):  
Antimicrobial Activity ◽  
Hydrazine Hydrate ◽  
Spectral Data ◽  
1H Nmr ◽  
Aromatic Aldehydes ◽  
Antimicrobial Activities ◽  
Gram Negative Bacteria ◽  
Schiff’S Bases ◽  
Gram Negative ◽  
Schiff's Bases

4-Chlorobenzylidene-2-methyl-(4H)-oxazol-5-one, which were prepared from 4-chlorobenzaldehyde and acetylglycine in reaction with hydrazine hydrate in ethanol gave 1-amino-4-(4-chlorobenzylidene)-2-methyl-1H-imidazolin-5(4H)-one. However, treatment of 4-chlorobenzylidene-2-methyl-(4H)-oxazol-5-one with hydrazine hydrate in pyridine yielded 3-(4-chlorophenyl)propanohydrazide. Reaction of 1-amino-4-(4-chlorobenzylidene)-2-methyl-1H-imidazolin-5(4H)-one with aromatic aldehydes gave eight corresponding Schiff’s bases namely 1-arylideneamino-4-(4-chlorobenzylidene)-2-methyl-1H-imidazolin-5(4H)-ones. The structure of the 3-(4-chlorophenyl)propanohydrazide and the imidazoline-5-one compounds was confirmed by IR, 1H-NMR and MS spectral data. The Schiff’s bases were tested for antimicrobial activities against several strains of Gram-positive, Gram-negative bacteria, molds and yeasts.

Green Synthesis, Characterization, DPPH and Ferrous Ion-chelating (FIC) Activity of Tetrakis-Schiff’s Bases of Terephthalaldehyde

2019 ◽  
Vol 16 (3) ◽  
pp. 249-255
Author(s):  
Momin Khan ◽  
Umar Ali ◽  
Anis Ur Rahman ◽  
Muhammad Ibrahim ◽  
Abdul Hameed ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Aromatic Aldehydes ◽  
Ferrous Ion ◽  
Future Research ◽  
Scavenging Activity ◽  
Schiff’S Bases ◽  
Schiff's Bases ◽  
Antioxidant Agents

Background: The role of small molecules as antioxidants to prevent the oxidation of other molecules and inhibit them from radical formation is the area of much interest to cure disease especially cancer. Moreover, the antioxidants play important role as stabilizers to prevent oxidation of fuels and lubricants. </P><P> Methods: In the present study, fifteen tetrakis-Schiff’s bases derivatives (1-15) were synthesized and screened for their antioxidant activities. Compounds 1-15 were synthesized by continuous stirring of reaction mixture of 1,4-bis (hydrazonomethyl)benzene (1 mmol) with various substituted aromatic aldehydes (2 mmol) in distilled water using acetic acid as catalyst at room temperature for 2-10 min. </P><P> Results: Our present study showed that all compounds are better ferrous ion-chelating agents except compound 1,4-bis((E)-((E)-(3,4-dimethoxybenzylidene)hydrazono)methyl)benzene (6) (IC50 = 329.26 &#177; 4.75 &#181;M) which has slightly low activity than the standard EDTA (IC50 = 318.40 &#177; 5.53 μM). In addition, DPPH radical scavenging activity of eleven compounds showed higher activity than the standard. However, remaining four compounds showed comparable radical scavenging activity to the standard DPPH (IC50 = 257.77 &#177; 4.60 &#181;M). </P><P> Conclusion: The series of fifteen Schiff’s bases (1-15) were synthesized and evaluated as antioxidants. From both assays, it has been demonstrated that most of the tetrakis-Schiff’s bases have potential to serve as leads for the development of antioxidant agents for future research.

scholarly journals Synthesis, Characterization and evaluation of Anti-inflammatory and Analgesic activity of Benzothiazole derivatives

2014 ◽  
Vol 2 (03) ◽  
pp. 84-89 ◽  
Author(s):  
Abhay Kumar Verma ◽  
Alex Martin ◽  
Arun Kumar Singh
Keyword(s):  
Benzoic Acid ◽  
1H Nmr ◽  
Mass Spectroscopy ◽  
Analgesic Activity ◽  
Aromatic Aldehydes ◽  
Spectroscopic Methods ◽  
Schiff’S Bases ◽  
Benzothiazole Derivatives ◽  
Anti Inflammatory ◽  
Analgesic Activities

A parent benzothiazole nucleus was synthesized by para amino acetanilide, then it is subjected to treatment with various substituted aromatic aldehydes to get the corresponding Schiff’s bases followed by treatment with pthalic anhydride to form 2-(6- acetamidobenzo[d]thiazol-2-ylcarbamoyl)benzoic acid. The structures of synthesized compounds were confirmed by various spectroscopic methods such as IR, 1H NMR and mass spectroscopy. The products were evaluated for their anti-inflammatory and analgesic activities. Some of the compounds exhibited potent activities when compared with the standards.

scholarly journals Synthesis of Some New Azetidinone Derivatives Containing Aryl Sulfonyloxy Group

2004 ◽  
Vol 1 (4) ◽  
pp. 194-198
Author(s):  
H. S. Patel ◽  
H. D. Desai
Keyword(s):  
Sodium Salt ◽  
Acetyl Chloride ◽  
Condensation Reaction ◽  
Aromatic Aldehydes ◽  
Schiff’S Bases ◽  
Aniline Derivative ◽  
Schiff's Bases

Some novel azetidinone derivatives containing aryl sulfonyloxy group have been prepared. The 4-sulfonyloxy aniline derivative (2) has been prepared by reaction of 4-nitro phenol (sodium salt) with N-acetyl sulfanilyl chloride (ASC) followed by hydrolysis by ethanolic HCl. This compound (2) undergoes facile condensation reaction with aromatic aldehydes to yield different Schiff’s bases (3a-h). Cyclocondensation of compounds (3a-h) with chloro acetyl chloride yields different 2-azetidinone derivatives (4a-h).

scholarly journals Synthesis, characterization and anti-bacterial activity of novel schiff bases of pyridin-3 yl-carbohydrazide derivatives

2021 ◽  
pp. 23-26
Author(s):  
Ravi Kumar Konda ◽  
Anish Kumar K ◽  
Phani Lakshman M ◽  
Mohammed Asif ◽  
Anusha Reddy D
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Schiff Bases ◽  
Wide Spectrum ◽  
Cyclic Compound ◽  
Aromatic Aldehydes ◽  
Bacterial Activity ◽  
Schiff’S Bases ◽  
Ethyl Nicotinate ◽  
Schiff's Bases

Heterocyclic compounds are cyclic compounds containing carbon and other heteroatoms. The most common heteroatoms are oxygen, nitrogen, and Sulphur. A heterocyclic compound is a cyclic compound that has atoms at least two different elements as members of its ring. A Schiff base (azomethine) is named after its inventor, Hugo Schiff and it is a functional group that contains a carbon-nitrogen double bond with the nitrogen atom connected to an aryl or alkyl group but not hydrogen. Schiff bases of Pyridin-3 yl-carbohydrazide derivatives from ethyl nicotinate and different aromatic aldehydes. Schiff’s bases are aromatic substituted imine compounds. These compounds are very important in the medicinal and pharmaceutical fields because of their wide spectrum of biological activity. Schiff’s bases show antibacterial activity, antifungal activity, and also antitumor activity. Aromatic aldehydes were refluxed with ethyl nicotinate using ethanol as a solvent to form Schiff's bases. All chemicals are taken in equimolar concentrations. The synthesized compounds were characterized by melting point, solubility, percentage yield, TLC, and IR spectral analysis. All derivatives are evaluated for anti-bacterial activity by the cup plate method. The antibacterial activity of test compounds was compared against standard Streptomycin. The 5 synthesized compounds show moderate antimicrobial activity. The experimental work summarizes the synthesis and in-vitro antibacterial activity of Schiff base derivatives.

scholarly journals Metal complexes of Schiff’s bases derived from 3-(arylazo)-2,4- -pentanediones with 2-aminophenol and 2-aminothiophenol

2007 ◽  
Vol 72 (11) ◽  
pp. 1075-1084 ◽  
Author(s):  
K. Krishnankutty ◽  
P. Sayudevi ◽  
Basheer Ummathur
Keyword(s):  
Metal Complexes ◽  
Spectral Data ◽  
1H Nmr ◽  
Analytical Data ◽  
Tetradentate Ligand ◽  
Carbonyl Groups ◽  
Schiff’S Bases ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Schiff's Bases

Phenylazo- and thiazolylazo-2,4-pentanediones on reaction with 2-aminophenol and 2-aminothiophenol yielded a new series of polydentate Schiff?s base ligands. The structure and tautomeric nature of these compounds and their metal complexes were established on the basis of their IR, 1H-NMR and mass spectral data. The spectral and analytical data revealed the condensation of both carbonyl groups of 3-(2-thiazolylazo)- 2,4-pentanedione with 2-aminophenol to form an N2O2 tetradentate ligand. Details on the formation of its [ML] complexes with Ni(II), Cu(II) and Zn(II) and the nature of their bonding are discussed based on analytical, IR, 1H-NMR and mass spectral data.

scholarly journals SYNTHESIS OF A NOVEL SERIES OF SCHIFF’S BASES FROM PABA AND PHENYL HYDRAZINE AND EVALUATION OF THEIR ANTIOXIDANT ACTIVITY

2021 ◽  
pp. 271-273
Author(s):  
Yalamanchili Praharsha ◽  
Sashmitha Samuel.B
Keyword(s):  
Potential Role ◽  
Antibacterial Activities ◽  
Schiff’S Bases ◽  
Phenyl Hydrazine ◽  
Efficient Procedure ◽  
Schiff's Bases ◽  
Anti Oxidant ◽  
Antibacterial And Antifungal ◽  
Areas Of Interest ◽  
Therapeutic Activities

Over the past decade, the synthesis of Schiff’s bases has become one of the main areas of interest in synthetic chemistry. These compounds have gained much attention, owing to their potential role as anti-inflammatory, anthelmintic, analgesic, antibacterial and antifungal agents. Thus, in view of the significance and diverse therapeutic activities of Schiff’s bases we have aimed at a simple and efficient procedure for their synthesis by the reaction of various aldehydes with PABA and phenyl hydrazine and also evaluation of their antibacterial activities. We have been successful in synthesizing various Schiff’s bases and also these compounds have been proved to have effective anti-oxidant activity. KEYWORDS: Schiff’s bases, PABA, Phenyl hydrazine, Aldehydes, Dioxan, Hydrogen peroxide, scavenging activity

Synthesis and Biological Evaluation of Chalconyl Incorporated Schiff’s Bases of Sulphonamides

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Neeraj Kumar ◽  
Dhruti Bhatt ◽  
Chandra Shekhar Sharma ◽  
Hamendra Pratap Singh ◽  
Harshda Pandiya ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Biological Evaluation ◽  
Antibacterial And Antifungal Activity ◽  
Schiff’S Bases ◽  
E Coli ◽  
Schiff's Bases ◽  
Microbial Strains ◽  
Antibacterial And Antifungal ◽  
Synthesis And Biological Evaluation

A series of of Chalconyl Incorporated Schiff’s Bases of Sulphonamides was synthesized by reacting substituted chalcone derivatives with Sulphacetamide sodium in methanol. All the title compounds synthesized (2a-2d) were tested for antibacterial and antifungal activity using E. coli, P. aeruginosa, S. aureus, S. pyogenus and C. albicans, A. niger and A. clavatus respectively as microbial strains and Sulphacetamide sodium as standard. The compound 2d showed significant antibacterial activity and 2a showed moderate antifungal activity as compared with Sulphacetamide Sodium.

scholarly journals Synthesis, Characterization and Antimicrobial Evaluation of Schiff’s Base and Aryl Aminomethyl Derivatives

2016 ◽  
Vol 64 ◽  
pp. 89-94
Author(s):  
N.N. Kansagara ◽  
V.R. Dangar ◽  
V.R. Shah
Keyword(s):  
Selective Reduction ◽  
Schiff’S Bases ◽  
Schiff’S Base ◽  
Chemical Structures ◽  
Imine Group ◽  
Schiff's Bases ◽  
Aminomethyl Derivatives ◽  
Aryl Amines ◽  
Antimicrobial Evaluation ◽  
Antibacterial And Antifungal

Schiff’s bases are obtained on heating an aldehydes with aromatic amine in presence of glacial acetic acid. These are the compounds containing characteristic –HC=N– group. Aryl amino methyl derivatives of heterocyclic compounds to synthesize by selective reduction of schiff’s bases (imine group) with sodiumborohydride in controlled experimental condition. Schiff’s base of N-Aryl-1-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]methanimines & Aryl amines of N-Aryl-1-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]methanamines were prepared. Their chemical structures were confirmed by means of IR, NMR, Mass data and by elemental analysis. All of the synthesized compounds were tested for their antibacterial and antifungal activity.

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