Embryonal rhabdomyosarcoma of the uterine cervix: a rare case report

Embryonal rhabdomyosarcoma of the female genital tract is a rare tumour. It tends to occur during childhood in the vagina and, rarely, it can arise in the uterine cervix, with a peak incidence in the second decade. We report a case of a 18-year-old female with an embryonal rhabdomyosarcoma (sarcoma botryoides) presenting himself as a cervical polyp. This tumour consisted of rhabdomyoblasts with miscellaneous differentiation surrounded by a loose, myxoid stroma. The patient was successfully treated with cervical conization and adjuvant chemotherapy. She is now disease-free at the 28th month follow-up. Awareness of this uncommon lesion in the cervix and its clinical implications is important to prevent misdiagnosis. Therapy has recently inclined to conservative and fertility-sparing treatment.

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Recurrent vaginal discharge: an unusual presentation of embryonal rhabdomyosarcoma of uterine cervix in an adolescent girl

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20191983 ◽

2019 ◽

Vol 8 (5) ◽

pp. 2129

Author(s):

Divya Sarin ◽

Urmila Singh ◽

Seema Mehrotra ◽

Vandana Solanki

Keyword(s):

Medical Treatment ◽

Uterine Cervix ◽

Adolescent Girl ◽

Vaginal Discharge ◽

Histopathological Examination ◽

Female Genital Tract ◽

Reproductive Function ◽

Embryonal Rhabdomyosarcoma ◽

Management Challenge

Embryonal rhabdomyosarcoma (ERMS) is a rare tumor of the female genital tract. It tends to occur during childhood in the vagina and rarely it can arise in the uterine cervix, with a peak incidence in the second decade. We report a case of 15 year old adolescent girl who presented with recurrent vaginal discharge not responding to medical treatment. Examination under anesthesia showed friable growth arising from the cervix. Histopathological examination revealed embryonal rhabdomyosarcoma (botyroid variant) of the cervix. Patient underwent local excision of growth followed by IRS-4 protocol based chemotherapy and now patient is under follow up at our side and pediatric oncology and doing well. Young girls presenting with recurrent vaginal discharge not responding to medical treatment must undergo proper clinical examination and EUA and any suspicious lesions should be examined so as to avoid missing rare but aggressive etiology like rhabdomyosarcoma. Due to the young age of affected patients, embryonal rhabdomyosarcoma (sarcoma botyroides) poses a management challenge as the preservation of hormonal, sexual and reproductive function is essential. Awareness of such as uncommon lesion and its clinical implications is important for the counseling and management of the patient.

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Extramedullary Hematopoiesis in the Uterine Cervix Associated with Tissue Repair

Case Reports in Obstetrics and Gynecology ◽

10.1155/2013/626130 ◽

2013 ◽

Vol 2013 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Suchanan Hanamornroongruang ◽

Chanon Neungton ◽

Malee Warnnissorn

Keyword(s):

Uterine Cervix ◽

Tissue Repair ◽

Female Genital Tract ◽

Extramedullary Hematopoiesis ◽

The Body ◽

Hematologic Disorder ◽

Abnormal Cervical Cytology ◽

Tract Involvement ◽

Female Genital

Extramedullary hematopoiesis (EMH) is the presence of hematopoietic precursors outside the bone marrow. This condition is usually associated with hematologic disorders. Although EMH can be found in almost every site in the body, female genital tract involvement is rare. The authors report EMH in the uterine cervix from a 64-year-old patient following cervical biopsy due to abnormal cervical cytology. Neither neoplasm nor hematologic disorder was detected before the diagnosis and after 1 year of follow up. To the best of our knowledge, this is the first reported case of EMH involving the uterine cervix which showed an association with tissue repair.

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MALIGNANT MELANOMA OF UTERINE CERVIX IN A YOUNG FEMALE

10.36106/ijsr/0803258 ◽

2019 ◽

pp. 1-2

Author(s):

Purvi Rathod

Keyword(s):

Malignant Melanoma ◽

Uterine Cervix ◽

Genital Tract ◽

External Beam Radiotherapy ◽

Female Genital Tract ◽

Young Female ◽

Rare Cancer ◽

Female Genital

Malignant melanoma is a rare cancer, its incidence being 1% of all cancers. Malignant melanoma of the female genital tract is even rarer with incidence of 3% to 7% of all malignant melanomas. It usually occurs in postmenopausal women. We present a case of malignant melanoma of the uterine cervix in a multiparous premenopausal 29 year old female. She underwent a modified radical hysterectomy. She was stage III and was treated with external beam radiotherapy to the pelvis followed by brachytherapy. Since then the patient was on regular follow up until she developed lung metastasis. Malignant melanoma of the cervix has very less data in literature. Through this case report we will emphasize on the role of radiotherapy in malignant melanoma of uterine cervix

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Cervical Mesonephric Adenocarcinoma: A Case Report of a Rare Gynecological Tumor from Embryological Remains of the Female Genital Tract

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0041-1725051 ◽

2021 ◽

Author(s):

Catarina Reis-de-Carvalho ◽

Carolina Vaz-de-Macedo ◽

Santiago Ortiz ◽

Anabela Colaço ◽

Carlos Calhaz-Jorge

Keyword(s):

Case Report ◽

Genital Tract ◽

Female Genital Tract ◽

Treatment Protocol ◽

Gynecology And Obstetrics ◽

Mesonephric Adenocarcinoma ◽

Gynecological Tumor ◽

Cervical Adenocarcinomas ◽

Female Genital

Abstract Introduction Malignant mesonephric tumors are uncommon in the female genital tract, and they are usually located where embryonic remnants of Wolffian ducts are detected, such as the uterine cervix. The information about these tumors, their treatment protocol, and prognosis are scarce. Case report A 60-year-old woman with postmenopausal vaginal bleeding was initially diagnosed with endometrial carcinoma. After suspicion co-testing, the patient underwent a loop electrosurgical excision of the cervix and was eventually diagnosed with mesonephric adenocarcinoma. She was subjected to a radical hysterectomy, which revealed International Federation of Gynecology and Obstetrics (FIGO) IB1 stage, and adjuvant radiotherapy. The follow-up showed no evidence of recurrence after 60 months. Conclusion We present the case of a woman with cervical mesonephric adenocarcinoma. When compared with the literature, this case had the longest clinical follow-up without evidence of recurrence, which reinforces the concept that these tumors are associated with a favorable prognosis if managed according to the guidelines defined for the treatment of patients with cervical adenocarcinomas. Though a rare entity, it should be kept in mind as a differential diagnosis for other cervical cancers.

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Malacoplakia of the Uterine Cervix: A Case Report

Pathogens ◽

10.3390/pathogens10030343 ◽

2021 ◽

Vol 10 (3) ◽

pp. 343

Author(s):

Adela Saco ◽

Natalia Rakislova ◽

Lorena Marimon ◽

Aureli Torne ◽

Berta Diaz-Feijoo ◽

...

Keyword(s):

Uterine Cervix ◽

Genital Tract ◽

Vaginal Bleeding ◽

Female Genital Tract ◽

Granulomatous Inflammation ◽

Resonance Imaging ◽

Chain Reaction ◽

Polymerase Chain ◽

Cervical Tumors ◽

Female Genital

Malacoplakia is an uncommon chronic granulomatous inflammation that rarely affects the female genital tract. A case of a 78-year-old woman with malacoplakia involving the uterine cervix and the vagina is described. The patient complained of vaginal bleeding. Clinically, a 13-mm mass was detected in the cervix, which was confirmed by ultrasound scan and magnetic resonance imaging. Histological examination showed a dense histiocytic infiltrate with abundant Michaelis–Gutmann bodies involving the uterine cervix and the upper vagina. The presence of Escherichia coli was confirmed in the lesion by immunohistochemistry and polymerase chain reaction. Only 12 cases of cervical malacoplakia have been reported to date. This condition should be included in the differential diagnosis of cervical tumors.

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Management of Transverse Vaginal Septum by Vaginoscopic Resection: Hymen Conservative Technique

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0038-1670714 ◽

2018 ◽

Vol 40 (10) ◽

pp. 642-646

Author(s):

Gennaro Scutiero ◽

Pantaleo Greco ◽

Piergiorgio Iannone ◽

Giulia Bernardi ◽

Francesca Greco ◽

...

Keyword(s):

Surgical Treatment ◽

Genital Tract ◽

Cultural Beliefs ◽

Foley Catheter ◽

Female Genital Tract ◽

Vaginal Septum ◽

Menstrual Flow ◽

Transverse Vaginal Septum ◽

Female Genital

AbstractTransverse vaginal septum is a rare female genital tract anomaly, and little is described about its surgical treatment. We report the case of a patient who wished to preserve hymenal integrity due to social and cultural beliefs. We performed a vaginoscopic resection of the septum under laparoscopic view, followed by the introduction of a Foley catheter in the vagina, thus preserving the hymen. After 12 months of follow-up, no septal closure was present, and the menstrual flow was effective. Vaginoscopic hysteroscopy is an effective method of vaginal septum resection, even in cases in which hymenal integrity must be preserved due to social and cultural beliefs.

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