scholarly journals The study of clinico-pathological correlation and treatment outcome in acute allograft rejection in the immediate post renal transplant period

2019 ◽  
Vol 7 (5) ◽  
pp. 1486
Author(s):  
Aadil Beigh ◽  
Bheem Raj Gupta ◽  
Gaurav Sagar ◽  
D. K. Agarwal
Keyword(s):  
Renal Transplant ◽  
Negative Impact ◽  
Mixed Group ◽  
Therapeutic Modalities ◽  
Transplant Patients ◽  
Immunosuppressive Medications ◽  
Observational Cohort ◽  
Short And Long Term

Background: The kidney Tx is the treatment of choice for patients with ESRD. However, episodes of AR have a negative impact on short- and long-term graft survival. In spite of immunosuppressive medications, CNI, MMF and steroid, the AR remains a crucial problem for Tx. This analysis was performed to evaluate the changing profile of early AR (during first week of transplant) and its repercussions on graft survival.Methods: This study was an observational cohort study and included 50 renal transplant patients irrespective of age, sex and race who developed bx proven AR within first week of transplant. Three groups were made according to histopathology: ACR, AMR and mixed rejection group. The patients were followed for 6 months thereafter.Results: AR within a week of renal Tx were less symptomatic except decrease in UO. ACR was more common (72%) than AMR and mixed rejections. AMR and Mixed group required more therapeutic modalities than ACR. More patients required HD during AR in AMR and mixed rejection group than ACR. The mean s.cr at 6 months was 1.3,1.5 and 1.6 in ACR, AMR and mixed group respectively. There were more incidences of BK viremia, CMV infection UTI and rejection fronts follow up in AMR and mixed group than ACR group.Conclusions: Acute rejections within a week are less symptomatic and ACR occurred more frequently than AMR and mixed rejection There were more incidences of BKV, CMV and UTI for 6 months follow up in AMR and Mixed rejection group.

Renography in the long-term follow-up of renal transplant patients

1979 ◽  
Vol 52 (615) ◽  
pp. 245-245 ◽  
Author(s):  
A. R. Constable ◽  
S. Adler ◽  
R. Cranage ◽  
E. Hogbin
Keyword(s):  
Renal Transplant ◽  
Transplant Patients ◽  
Long Term Follow Up ◽  
Renal Transplant Patients

24HABPM IN THE LONG TERM FOLLOW UP OF RENAL TRANSPLANT PATIENTS

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e120-e121
Author(s):  
F. Mallamaci ◽  
R. Tripepi ◽  
G. D’Arrigo ◽  
G. Porto ◽  
M.C. Versace ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Transplant Patients ◽  
Long Term Follow Up ◽  
Renal Transplant Patients

Long-term blood pressure monitoring by office and 24-h ambulatory blood pressure in renal transplant patients: a longitudinal study

2018 ◽  
Vol 34 (9) ◽  
pp. 1558-1564 ◽  
Author(s):  
Francesca Mallamaci ◽  
Rocco Tripepi ◽  
Graziella D'Arrigo ◽  
Gaetana Porto ◽  
Maria Carmela Versace ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Longitudinal Study ◽  
Renal Transplant ◽  
Blood Pressure Monitoring ◽  
Pressure Monitoring ◽  
Nocturnal Hypertension ◽  
Transplant Patients ◽  
Renal Transplant Patients

Abstract Background Renal transplant patients have a high prevalence of nocturnal hypertension, and hypertension misclassification by office blood pressure (BP) is quite common in these patients. The potential impact of hypertension misclassification by office BP on hypertension management in this population has never been analysed. Methods We performed a longitudinal study in a cohort of 260 clinically stable renal transplant patients. In all, 785 paired office and 24-h ambulatory blood pressure monitoring (24-hABPM) measurements over a median follow-up of 3.9 years were available in the whole cohort. Results A total of 74% of patients had nocturnal hypertension (>120/70 mmHg). Average office BP and 24-hABPM remained quite stable over follow-up, as did the prevalence of nocturnal hypertension, which was 77% at the last observation. However, the global agreement between office BP and average 24 h, daytime and night-time BP was unsatisfactory (k-statistics 0.10–0.26). In 193 visits (25% of all visits) where office BP indicated the need of antihypertensive therapy institution or modification (BP >140/90 mmHg), 24-hABPM was actually normal (<130/80 mmHg), while in 94 visits (12%), 24-hABPM was in the hypertensive range while office BP was normal. Overall, in 37% of visits, office BP provided misleading therapeutic indications. Conclusions Hypertension misclassification by office BP is a common phenomenon in stable renal transplant patients on long-term follow-up. Office BP may lead to inappropriate therapeutic decisions in over one-third of follow-up visits in these patients.

Renography in the long-term follow-up of renal transplant patients

1979 ◽  
Vol 52 (615) ◽  
pp. 245-245
Author(s):  
C. C. Doherty ◽  
J. F. Douglas ◽  
Mary G. McGeown
Keyword(s):  
Renal Transplant ◽  
Transplant Patients ◽  
Long Term Follow Up ◽  
Renal Transplant Patients

Isotope renography and long-term follow-up of renal transplant patients

1978 ◽  
Vol 51 (610) ◽  
pp. 802-807 ◽  
Author(s):  
C. C. Doherty ◽  
J. F. Douglas ◽  
Mary G. McGeown
Keyword(s):  
Renal Transplant ◽  
Transplant Patients ◽  
Long Term Follow Up ◽  
Renal Transplant Patients

Treatment of HCV in renal transplant patients with peginterferon and ribavirin: long-term follow-up

2017 ◽  
Vol 21 (5) ◽  
pp. 764-770
Author(s):  
Siu-ka Mak ◽  
Ho-kwan Sin ◽  
Kin-yee Lo ◽  
Man-wai Lo ◽  
Shuk-fan Chan ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Transplant Patients ◽  
Long Term Follow Up ◽  
Renal Transplant Patients ◽  
Peginterferon And Ribavirin

scholarly journals Therapy for persistent hypercalcemic hyperparathyroidism post-renal transplant: cinacalcet versus parathyroidectomy

2020 ◽  
Vol 42 (3) ◽  
pp. 315-322
Author(s):  
Gabriel Giollo Rivelli ◽  
Marcelo Lopes de Lima ◽  
Marilda Mazzali
Keyword(s):  
Renal Function ◽  
Renal Transplant ◽  
Serum Calcium ◽  
Laboratory Data ◽  
Renal Transplant Recipients ◽  
Therapeutic Modalities ◽  
Transplant Patients ◽  
Persistent Hyperparathyroidism ◽  
One Year

ABSTRACT Background: Persistent hyperparathyroidism post-transplant is associated with increases in the incidence of cardiovascular events, fractures, and deaths. The aim of this study was to compare both therapeutic options available: parathyroidectomy (PTX) and the calcimimetic agent cinacalcet. Methods: A single center retrospective study including adult renal transplant recipients who developed hypercalcemia due to persistent hyperparathyroidism. Inclusion criteria: PTH > 65 pg/mL with serum calcium > 11.5 mg/dL at any time after transplant or serum calcium persistently higher than 10.2 mg/dL one year after transplant. Patients treated with cinacalcet (n=46) were compared to patients treated with parathyroidectomy (n=30). Follow-up period was one year. Clinical and laboratory data were analyzed to compare efficacy and safety of both therapeutic modalities. Results: PTX controlled calcemia faster (month 1 x month 6) and reached significantly lower levels at month 12 (9.1±1.2 vs 9.7±0.8 mg/dL, p < 0.05); PTX patients showed significantly higher levels of serum phosphate (3.8±1.0 vs 2.9±0.5 mg/dL, p < 0.05) and returned PTH to normal levels (45±51 pg/mL). Cinacalcet, despite controlling calcium and phosphate in the long term, decreased but did not correct PTH (197±97 pg/mL). The proportion of patients that remained with PTH above normal range was 95% in the cinacalcet group and 22% in the PTX group. Patients treated with cinacalcet had better renal function (creatinine 1.2±0.3 vs 1.7±0.7 mg/dL, p < 0.05). Conclusions: Surgical treatment was superior to cinacalcet to correct the metabolic disorders of hyperparathyroidism despite being associated with worse renal function in the long term. Cinacalcet proved to be a safe and well tolerated drug.

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