scholarly journals Comparative study of retinal nerve fibre layer thickness in normal and glaucomatous human eyes as measured by optical coherence tomography

2020 ◽  
Vol 8 (4) ◽  
pp. 1375
Author(s):  
Ritu Jain ◽  
Nupur Choudhary
Keyword(s):  
Diagnostic Accuracy ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Mean Deviation ◽  
Care Hospital ◽  
Rnfl Thickness ◽  
Fibre Layer ◽  
Department Of Ophthalmology ◽  
Significant Difference ◽  
Nerve Fibre Layer

Background: Glaucoma is a disease primarily associated with damage to the Retinal Ganglion Cell (RGC) bodies and axons, which causes characteristic patterns of Visual Field (VF) and changes in the appearance of the Optic Nerve Head (ONH). This Study Compares Nerve Fibre layer thickness in normal and Glaucomatous Human Eye.Methods: It is a case control observational study carried out in 100 patients in a tertiary eye care hospital in the department of ophthalmology in the period from 1st January 2019 to 30th June 2019.Results: The diagnostic ability for distinguishing between normal and glaucoma patients were same when authors consider average RNFL thickness and average GCC thickness. Diagnostic accuracy increases when authors consider both RNFL and GCC thickness. There was a significant difference in both RNFL and GCC thickness between normal and glaucoma patient (p<0.001). The mean deviation shows a significant correlation with all the parameters in eyes with glaucoma (<0.001).Conclusions: RNFL thickness as measured by OCT showed statistically significant correlation with glaucoma. RNFL seems to have higher sensitivity and specificity for the detection of early glaucoma. Diagnostic accuracy increases when we include other parameters like RNFL and visual fields.

scholarly journals COMPARISION OF RETINAL NERVE FIBRE LAYER THICKNESS BY CIRRUS HD-OPTICAL COHERENCE TOMOGRAPHY IN EMMETROPIC, MYOPIC AND HYPEROPIC EYES

2021 ◽  
Vol 9 (01) ◽  
pp. 62-71
Author(s):  
S. Mounica ◽  
◽  
B.V. Kranthi ◽  
M. Lakshmi Sarvani ◽  
◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Optical Coherence ◽  
College Hospital ◽  
Rnfl Thickness ◽  
Fibre Layer ◽  
Department Of Ophthalmology ◽  
Nerve Fibre Layer

Purpose: The purpose of our study is to compare the average peripapillary retinal nerve fibre layer thickness by cirrus HD-Optical coherence tomography in emmetropic, axial myopic and axial hyperopic cases. Materials And Methods: Total of 120 subjects aged between 10 to 50 years were enrolled in this study, divided into 3 groups with 40 in each, namely group 1 - emmetropia, group 2- myopia >2.5 D and group 3-hypermetropia>2.5 D. In which, 58 (48.3%) were females and 62 (51.7%) were males. This study was done in the Department of Ophthalmology, Santhiram Medical College Hospital Nandyal,from October 2019 to March 2020. The average as well as quadratic assessment of peripapillary RNFL thickness by cirrus-HD optical coherence tomography and comparison among these 3 groups. Observation And Results: In our study, average peripapillary RNFL thickness between emmetropic, myopic and hyperopic groups was found to be statistically significant. The average peripapillary RNFL thickness was thickest in the hyperopic group (102.95 ± 5.629, n=40), followed by the emmetropic group (102.55 ± 5.505, n=40), and then the myopic group (83.38 ± 3.726, n=40) (all P<0.0001) . And in all four RNFL quadrants, myopic group showed thinning when compared to Emmetropic and hyperopic group (p<0.001).But hyperopic group showed thicker RNFL than emmetropic group only in temporal quadrants in right eye(p<0.001)and nasal and superior quadrants in left eye (p=0.017) Conclusion: In our study, average as well as in all the four quadrants peripapillary RNFL thickness shows highly significant results between emmetropia, myopia and hyperopia. When compared with emmetropia, RNFL thickness being thinnest in myopic group, and slightly thicker RNFL thickness in hyperopic group.

Comparison of retinal ganglion cell-related layer asymmetry between early glaucoma eyes with superior and inferior hemiretina damage

2019 ◽  
Vol 104 (5) ◽  
pp. 655-659 ◽  
Author(s):  
Hitomi Saito ◽  
Aiko Iwase ◽  
Makoto Araie
Keyword(s):  
Ganglion Cell ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Retinal Ganglion Cell ◽  
Retinal Nerve Fibre Layer ◽  
Retinal Ganglion ◽  
Fibre Layer ◽  
Significant Difference ◽  
Nerve Fibre Layer ◽  
Normal Controls

AimTo compare retinal ganglion cell (RGC)-related layer thickness asymmetry between early open-angle glaucoma (EG) eyes with superior and inferior hemiretina damage.MethodsThis was a retrospective study including 95 EG eyes (mean deviation >−2 dB, including 43 preperimetric glaucoma eyes) with photographically determined glaucomatous retinal nerve fibre layer defect and disc change confined to one hemiretina, and 93 age, sex and refraction matched normal subjects as controls. Ganglion cell complex, ganglion cell layer+inner plexiform layer and circumpapillary retinal nerve fibre layer thickness measured by spectral domain optical coherence imaging were compared between the affected and unaffected hemiretinae within each glaucoma eye as well as to those of the corresponding hemiretina of normal control eyes.ResultsIntraeye comparison revealed that there was no significant difference in all parameters between the affected and unaffected hemiretinae in eyes with superior hemiretina damage (p=0.110~0.343) while all parameters were thinner in the affected inferior hemiretina compared with the unaffected superior hemiretina in eyes with inferior hemiretina damage (p<0.001). The affected hemiretina of both groups were thinner compared with normal controls (p<0.001). All parameters of the unaffected hemiretina of eyes with superior hemiretina damage were thinner than normal controls (p<0.001), while eyes with inferior hemiretina damage showed no significant difference compared with those of their corresponding hemiretina of normal eyes (p=0.086~0.924).ConclusionThe pattern of RGC damage in early stage glaucoma may differ depending on which horizontal hemiretina is affected first.

Factors affecting the diagnostic performance of circumpapillary retinal nerve fibre layer measurement in glaucoma

2020 ◽  
pp. bjophthalmol-2020-315985 ◽  
Author(s):  
Damon Wong ◽  
Jacqueline Chua ◽  
Mani Baskaran ◽  
Bingyao Tan ◽  
Xinwen Yao ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Nerve Fibre ◽  
Disease Severity ◽  
Healthy Subjects ◽  
Diagnostic Performance ◽  
Retinal Nerve Fibre Layer ◽  
Automated Perimetry ◽  
Rnfl Thickness ◽  
Fibre Layer ◽  
Nerve Fibre Layer

Background/aimsTo identify factors that influence the diagnostic performance of circumpapillary retinal nerve fibre layer (RNFL) thickness measurements in the detection of primary open-angle glaucoma (POAG).Methods1592 eyes from 1076 healthy controls and 758 eyes from 502 patients with POAG underwent optical coherence tomography (OCT) imaging to assess RNFL parameters. Visual field (VF) mean deviation (MD) from standard automated perimetry was used to indicate severity in subjects with glaucoma.ResultsRNFL thickness significantly decreased with age (ρ=−0.10 to −0.16, p<0.001) and increased with spherical equivalent (SE) refractive error (ρ=0.23–0.29, p<0.001) in healthy and glaucoma groups but showed a significant reduction with SE (ρ=−0.20, p<0.001) in the temporal RNFL of healthy subjects. RNFL measurements significantly decreased with VF MD (ρ=0.08–0.53, p<0.05) in subjects with POAG. When healthy subjects and subjects with glaucoma were matched to subgroups within a factor, significant differences in area under the curve (AUC) between subgroups were only found with SE AUCs increased significantly with disease severity, particularly in the global, inferior and superior measurements (p<0.001). Overall, the diagnostic performance of the inferior and global RNFL measurements were found to be more resilient to different factors.ConclusionDiagnostic accuracy in glaucoma was influenced by SE but could be mitigated by using controls with similar refractive characteristics. Increasing disease severity led to significantly better diagnostic accuracy. These factors should be considered when using OCT for glaucoma diagnosis in practice.

Is retinal nerve fibre layer thickness correlated with visual function in individuals having optic neuritis?

2021 ◽  
pp. 1-7
Author(s):  
Abbas Ali Yekta ◽  
Sara Sorouh ◽  
Amir Asharlous ◽  
Ali Mirzajani ◽  
Ebrahim Jafarzadehpur ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Visual Function ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer

Influence of uveitis on Bruch’s membrane opening minimum rim width and retinal nerve fibre layer thickness measurements

2018 ◽  
Vol 103 (10) ◽  
pp. 1413-1417 ◽  
Author(s):  
Matthias F Kriegel ◽  
Arnd Heiligenhaus ◽  
Carsten Heinz
Keyword(s):  
Layer Thickness ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Bruch's Membrane ◽  
Bruch’S Membrane ◽  
Fibre Layer ◽  
Bruch’S Membrane Opening ◽  
Nerve Fibre Layer ◽  
Active Inflammation ◽  
The Impact

Background/aimsTo assess the impact of papillary leakage and active inflammation on optical coherence tomography (OCT)-based retinal nerve fibre layer thickness (RNFLT) and Bruch’s membrane opening minimum rim width (BMO-MRW) measurements in uveitic eyes with and without secondary glaucoma.MethodsProspective, single-centre analysis of patients with uveitis. All patients included received a fluorescein angiography examination and an OCT scan measuring the BMO-MRW and the RNFLT in three concentric peripapillary ring scans.ResultsOverall, 95 eyes of 56 patients were enrolled. Papillary leakage and active inflammation were present in 39 (41%) and 57 (60%) eyes, respectively. Twenty-one eyes were classified as glaucomatous; 10 of those glaucomatous eyes showed papillary leakage. Both BMO-MRW and RNFLT measurements were significantly increased in eyes with papillary leakage (BMO-MRW: p=0.0001; RNFLT: first to third ring (p<0.0001)). Active inflammation led to a significantly thickened RNFLT (first ring: p=0.0026; second ring: p=0.0009; third ring: p=0.0002) while only a trend towards increased values could be observed in the BMO-MRW measurements (p=0.3063). Glaucomatous eyes with papillary leakage demonstrated significantly higher values on both BMO-MRW and RNFLT measurements than glaucomatous eyes without leakage (BMO-MRW: p=0.0159; RNFLT: first ring: p=0.0062; second ring: p=0.0037; third ring: p=0.0197). No significant difference could be observed between glaucomatous eyes with leakage and non-glaucomatous eyes without leakage (BMO-MRW: p=0.4132; RNFLT: first ring: p=0.5412; second ring: p=0.3208; third ring: p=0.1164).ConclusionsThe OCT scanning parameters BMO-MRW and RNFLT were significantly influenced by papillary leakage in uveitic eyes with and without glaucoma. RNFLT values were also significantly increased while active inflammation was present. In patients with uveitis, these OCT-based imaging tools should be interpreted with caution, especially in those with papillary leakage or active inflammation.

Sign in / Sign up

Export Citation Format

Share Document