Relation between monocyte/high density lipoprotein ratio in acute ischemic stroke severity

Introduction: Stroke is a common neurological condition, with a high incidence of mortality and morbidity, especially in the elderly population. Inflammation and lipid abnormalities have been proposed for the pathophysiology development and progression of atherosclerosis. Monocyte count to High density lipoprotein (HDL) ratio (MHR) is proposed as a novel predictor of prognosis in cardiovascular diseases. In this study, we aim to investigate the relationship of MHR with stroke severity in acute ischemic stroke patients.Methods: A total of 64 patients with acute ischemic stroke were inpatients of RLJH were included in the study. Patients were divided into 2 groups according to the National institute of health stroke (NIHS) score (group 1; national institute of health stroke scale (NIHSS) <16, group 2; NIHSS ≥16). MHR is the ratio obtained by dividing the monocyte count with HDL from a peripheral blood sample. Then the association between MHR and NIHSS score at the time of admission is evaluated.Results: Accordingly, the results obtained revealed MHR was significantly lower in group 1 patients who have lower NIHSS score than group 2 patients who have higher NIHSS.Conclusion: This study suggests that MHR is associated with stroke severity on admission in patients with acute ischemic stroke.

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Relation between Monocyte/High Density Lipoprotein Ratio Acute Ischemic Stroke Severity

The American Journal of Cardiology ◽

10.1016/j.amjcard.2018.03.238 ◽

2018 ◽

Vol 121 (8) ◽

pp. e103

Author(s):

Onder Ozturk ◽

Unal Ozturk ◽

Sebnem Nergiz ◽

Bernas Altıntaş ◽

Erkan Baysal

Keyword(s):

Ischemic Stroke ◽

High Density Lipoprotein ◽

Acute Ischemic Stroke ◽

Density Lipoprotein ◽

High Density ◽

Stroke Severity

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Abstract P193: High Density Lipoprotein is Superior to Triglyceride as a Biomarker of Physiologic Stress in African Immigrants: The Africans in America Study

Circulation ◽

10.1161/circ.137.suppl_1.p193 ◽

2018 ◽

Vol 137 (suppl_1) ◽

Author(s):

Rafeal L Baker ◽

Jean N Utumatwishima ◽

Stephanie T Chung ◽

Anne E Sumner

Keyword(s):

High Density Lipoprotein ◽

Allostatic Load ◽

Density Lipoprotein ◽

African Immigrants ◽

Cardiac Risk ◽

The United States ◽

High Density ◽

Significant Difference ◽

Group 2 ◽

Group 1

Introduction: For Africans living in the United States, the extent to which stress-induced physiologic dysfunction varies by reason for immigration is unknown. Allostatic load score (ALS) is used to assess physiologic stress. ALS has biomarkers in 3 domains: cardiovascular, metabolic and immune. However, there are many ALS equations and the number of biomarkers in each domain varies. In the cardiac domain of ALS, equations use either triglyceride (TG) or high density lipoprotein (HDL). A specific problem for African descent populations is that HDL may be superior to TG as a marker of insulin resistance and cardiac risk. Objective: Our primary goal in 95 African immigrants (71% male, age 42±10, (mean±SD), range 22-62y) was to determine if ALS varied by reason for immigration. Our secondary goal was to evaluate 4 different ALS equations to determine if there was a difference in ALS performance depending on whether HDL or TG was the included biomarker. Methods and Results: For all 4 equations, the reasons for immigration from lowest to highest ALS were: family reunification, lottery for self and immediate family, marriage, asylum, work and study (Figure 1). As the first 3 reasons for immigration promoted family unity, they were grouped together (Group 1). The Africans who came for other reasons were grouped together (Group 2). Equations 1 and 2 included HDL as a biomarker. For these equations, ALS in Group 1 vs. Group 2 were: 1.7±1.3 vs. 2.8±1.7, P <0.01 and 1.4±1.2 vs. 2.3±1.7, P <0.01 resp. Equations 3 and 4 used TG. For these two equations ALS in Group 1 vs. Group 2 were: 2.2±1.6 vs. 2.9±2.0, P =0.08 and 2.1±1.4 vs. 2.9±2.0, P =0.03 resp. In Equations 1 and 2, when HDL was replaced by TG, the significant difference in ALS between groups declined. In Equations 3 and 4, when TG was replaced by HDL, the significant difference in ALS between groups increased. Conclusions: ALS varies by reason for immigration and is easier to detect in ALS equations which use HDL rather than TG.

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Impaired antioxidative activity of high-density lipoprotein is associated with more severe acute ischemic stroke

Metabolism ◽

10.1016/j.metabol.2019.06.004 ◽

2019 ◽

Vol 98 ◽

pp. 49-52 ◽

Cited By ~ 1

Author(s):

Konstantinos Tziomalos ◽

Konstantina Katrini ◽

Marianthi Papagianni ◽

Konstantinos Christou ◽

Christina Gkolfinopoulou ◽

...

Keyword(s):

Ischemic Stroke ◽

High Density Lipoprotein ◽

Acute Ischemic Stroke ◽

Antioxidative Activity ◽

Density Lipoprotein ◽

High Density

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Monocyte-to-High-Density Lipoprotein Ratio Predicts the Outcome of Acute Ischemic Stroke

Journal of Atherosclerosis and Thrombosis ◽

10.5551/jat.51151 ◽

2020 ◽

Vol 27 (9) ◽

pp. 959-968

Author(s):

Hongbing Liu ◽

Kai Liu ◽

Lulu Pei ◽

Yuan Gao ◽

Lu Zhao ◽

...

Keyword(s):

Ischemic Stroke ◽

High Density Lipoprotein ◽

Acute Ischemic Stroke ◽

Density Lipoprotein ◽

High Density

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Low triglyceride to high-density lipoprotein cholesterol ratio predicts hemorrhagic transformation in large atherosclerotic infarction of acute ischemic stroke

Aging ◽

10.18632/aging.101859 ◽

2019 ◽

Vol 11 (5) ◽

pp. 1589-1601 ◽

Cited By ~ 6

Author(s):

Qi-Wen Deng ◽

Yu-Kai Liu ◽

Yu-Qiao Zhang ◽

Xiang-Liang Chen ◽

Teng Jiang ◽

...

Keyword(s):

Ischemic Stroke ◽

High Density Lipoprotein ◽

Acute Ischemic Stroke ◽

High Density Lipoprotein Cholesterol ◽

Density Lipoprotein ◽

Hemorrhagic Transformation ◽

High Density ◽

Lipoprotein Cholesterol ◽

Cholesterol Ratio

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The relationship between uric acid to high-density lipoprotein cholesterol ratio and collateral index in patients with chronic total occlusion

Kardiologiia ◽

10.18087/cardio.2021.9.n1750 ◽

2021 ◽

Vol 61 (9) ◽

pp. 61-65

Author(s):

Cihan Aydın ◽

Nadir Emlek

Keyword(s):

Uric Acid ◽

High Density Lipoprotein ◽

High Density Lipoprotein Cholesterol ◽

Collateral Circulation ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Total Occlusion ◽

Group 2 ◽

Group 1

Background High serum uric acid (UA) levels and low high-density lipoprotein cholesterol (HDL–C) levels are accepted as risk factors for cardiovascular mortality. Hyperuricemia and low HDL–C levels were associated with an increased risk of cardiovascular mortality and the development of diabetes and hypertension. However, the association of UA with cardiovascular (CV) mortality,collateral index are undetermined in patients with chronic total occlusion (CTO).Material and methods 124 patients who underwent coronary angiography with the diagnosis of stable or unstable angina pectoris and had chronic total occlusion were included in our study. Blood samples were collected from all patients before the angiography procedure. Coronary collateral circulation (CCC) was graded according to the Rentrop grading system of 0–3. Rentrop grades of 0 and 1 indicated low-grade CCC group, whereas grades 2 and 3 indicated high-grade CCC group. We divided our patients into two groups as low-grade CCC and high-grade CCC and examined these two groups in terms of uric acid / HDL ratios. Group 1: Rentrop classification grade 0–1 (mean age, 63,9±9,9), Group 2: Rentrop classification grade 2–3 (mean age, 62,1±9,4).Results The baseline characteristics were similar in both groups. Uric acid / High density lipoprotein-cholesterol ratios and uric acid levels were higher in group 1 with poor collateral circulation [group 1; 0,21 (0,07–0,39) vs. group 2; 0,16 (0,08–0,31), group 1; 8,2 (3,4–10,4) vs. group 2; 5,85 (3,5–7,7), p<0,001, p<0,001 respectively].Conclusions We found that high Uric acid / High-density lipoprotein-cholesterol ratios and high uric acid levels are associated with poor collateral circulation.

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